10 Questions
What is the primary function of the Origin Recognition Complex (ORC) in DNA replication?
To ensure that each region of the DNA is replicated once and only once in each S phase
What is the role of histone chaperones in DNA replication?
To restore the full complement of histones
What is the consequence of the lagging-strand replication machinery reaching the end of the chromosome?
An incomplete replication resulting in a short ssDNA region at the 3’ end of the lagging-strand DNA product
What is the function of telomerase in DNA replication?
To replicate the ends of chromosomes
What is the composition of telomerase?
Multiple protein subunits and RNA
What is the outcome of the shortening of one of the two products in the next round of replication?
A gradual shortening of the chromosome
What is the purpose of telomere packaging into specialized structures?
To protect the ends of chromosomes
What is the process by which DNA replication is terminated?
The ordered disassembly of the replication fork
What is the role of chaperone FACT in DNA replication?
To facilitate the disassembly of histones in front of the replication fork
What is the consequence of the incomplete replication of the lagging-strand DNA product?
A shortening of the chromosome
Test your understanding of DNA replication and repair mechanisms, including the role of special proteins, the replication fork, and mismatch repair systems. Learn about the similarities and differences between eukaryotes and bacteria in DNA replication.
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