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DNA Replication and Repair Mechanisms

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Questions and Answers

What is the primary function of the Origin Recognition Complex (ORC) in DNA replication?

To provide the template for the new telomere

To ensure that each region of the DNA is replicated once and only once in each S phase (correct)

To synthesize new RNA primers

To facilitate the disassembly of histones in front of the replication fork

What is the role of histone chaperones in DNA replication?

To restore the full complement of histones (correct)

To synthesize new RNA primers

To facilitate the assembly of new nucleosomes behind the replication fork

To disassemble histones in front of the replication fork

What is the consequence of the lagging-strand replication machinery reaching the end of the chromosome?

A reversal of the replication direction

An incomplete replication resulting in a short ssDNA region at the 3’ end of the lagging-strand DNA product (correct)

A pause in the replication process

A complete replication of the chromosome

What is the function of telomerase in DNA replication?

To replicate the ends of chromosomes Signup and view all the answers

What is the composition of telomerase?

Multiple protein subunits and RNA Signup and view all the answers

What is the outcome of the shortening of one of the two products in the next round of replication?

A gradual shortening of the chromosome Signup and view all the answers

What is the purpose of telomere packaging into specialized structures?

To protect the ends of chromosomes Signup and view all the answers

What is the process by which DNA replication is terminated?

The ordered disassembly of the replication fork Signup and view all the answers

What is the role of chaperone FACT in DNA replication?

To facilitate the disassembly of histones in front of the replication fork Signup and view all the answers

What is the consequence of the incomplete replication of the lagging-strand DNA product?

A shortening of the chromosome Signup and view all the answers