Lecture 3

Which of the following types of DNA lesions is believed to be the most critical?

Which of the following is the primary target for the biological effects of radiation?

Which of the following is NOT one of the four bases that determine the genetic code in DNA?

What is the consequence of defects in DNA mismatch repair?

Which phase of mitosis is characterized by the movement of chromosomes to the center of the cell?

What is the function of telomeres in chromosomes?

Which technique is currently used to measure DNA strand breaks?

What is the advantage of using the comet assay to measure DNA damage and repair?

Which repair pathway is used to repair DNA double-strand breaks (DSBs)?

Which repair pathway efficiently repairs base damage caused by ionizing radiation?

Which pathway repairs DNA double-strand breaks by joining the ends of the broken DNA without requiring homology?

Which of the following is the primary target for the biological effects of radiation?

What is the function of DNA in the cell?

Which of the following types of DNA damage is believed to be the most critical?

What are the four bases that determine the genetic code in DNA?

Which repair pathway efficiently repairs DNA double-strand breaks using an undamaged DNA strand as a template for repair?

Which phase of mitosis is characterized by the movement of chromosomes to the center of the cell?

Which technique is currently used to measure DNA strand breaks?

Which technique is widely used to detect and study DNA double-strand breaks (DSBs)?

Which technique is advantageous for studying biopsy specimens from tumors?

Which repair pathway is used to repair base damage in DNA?

Which repair pathway efficiently repairs base damage caused by ionizing radiation?

Which repair pathway removes bulky adducts from DNA, such as pyrimidine dimers formed by UV light?

What is the consequence of defects in DNA mismatch repair?

Which phase of mitosis is characterized by the movement of chromosomes to the center of the cell?

What are telomeres?

What is the association between telomere shortening and aging?

Which type of aberration occurs if a cell is irradiated early in interphase, before the chromosome material has been duplicated?

Which type of aberration occurs if the broken ends of chromosomes fail to rejoin after ionizing radiation?

Which type of aberration is characterized by a chromatid being stretched between the two poles of the cell at anaphase?

Which of the following repair pathways is error-prone and predominantly found in the G1 phase of the cell cycle in mammalian cells?

Which repair pathway removes base-base and small insertion mismatches that occur during replication and homologous recombination?

Which of the following repair pathways requires an undamaged DNA strand as a template for repair and is predominantly found in lower eukaryotes and late S/G2 phase of the cell cycle in mammalian cells?

Which repair pathway repairs DNA double-strand breaks by joining the ends of the broken DNA without requiring homology?

Which repair pathway repairs DNA double-strand breaks using an undamaged DNA strand as a template for repair?

Which repair pathway is predominantly found in the G1 phase of the cell cycle in mammalian cells?