DNA Repair Mechanisms Quiz
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Questions and Answers

What can lead to the formation of loops in the template strand during DNA replication?

  • Deamination
  • Replication slippage (correct)
  • Tautomeric shifts
  • Depurination
  • Which genetic disorder can result from the skipping over of loops by DNA polymerase during replication?

  • Fragile-X syndrome (correct)
  • Huntington’s disease
  • Alkaptonuria
  • Sickle cell anemia
  • What process involves the spontaneous change from one tautomer to another, leading to non-complementary base-pairing?

  • Deamination
  • Depurination
  • Induced replication
  • Tautomeric shifts (correct)
  • What is the term for the random loss of a nucleotide's purine base?

    <p>Depurination</p> Signup and view all the answers

    Which mutagen can add bulky carbon chains like methyls or ethyls to DNA bases?

    <p>Alkylating agents</p> Signup and view all the answers

    What type of radiation sensitivity can base analogs contribute to?

    <p>UV radiation sensitivity</p> Signup and view all the answers

    If cytosine loses an amino group and an oxygen is added in its place, what base does it change to?

    <p>Uracil</p> Signup and view all the answers

    Which process involves the filling of an apurinic site with an adenine nucleotide?

    <p>Depurination</p> Signup and view all the answers

    What is the function of enhancers in gene regulation?

    <p>Enhancers can enhance any gene nearby</p> Signup and view all the answers

    Which of the following actions do silencers perform in gene regulation?

    <p>Silencers block enhancers to inhibit gene expression</p> Signup and view all the answers

    What effect does methylation of DNA have on transcription?

    <p>Methylation inhibits transcription</p> Signup and view all the answers

    What is RNA-induced gene silencing?

    <p>A type of RNA interference regulating translation</p> Signup and view all the answers

    Which enzyme is responsible for cleaving double-stranded RNA during a viral infection to produce siRNA?

    <p>Dicer</p> Signup and view all the answers

    What is the function of microRNA in gene expression regulation?

    <p>MicroRNA inhibits gene expression</p> Signup and view all the answers

    Which complex is responsible for RNA-induced silencing in gene regulation?

    <p><strong>RISC:</strong> RNA-induced silencing complex</p> Signup and view all the answers

    What is the role of a repressor protein in negative control?

    <p>Inhibits transcription</p> Signup and view all the answers

    Which of the following describes the function of the allosteric domain of a repressor protein?

    <p>Binds a molecule to change DNA binding domain shape</p> Signup and view all the answers

    What is the main function of an activator protein in positive control?

    <p>Initiates transcription</p> Signup and view all the answers

    How do most activator proteins become active for transcription initiation?

    <p>Bonding with an allosteric compound</p> Signup and view all the answers

    What factor is expressed during the heat shock response due to unstable conditions?

    <p>Alternative sigma factor (sigma 32)</p> Signup and view all the answers

    What role do chaperone proteins play in the heat shock response?

    <p>Inhibit sigma 32 at hot temperatures</p> Signup and view all the answers

    What are riboswitches and how do they control gene expression?

    <p>Noncoding mRNA segments controlling downstream gene expression by metabolite binding</p> Signup and view all the answers

    Which DNA repair mechanism involves the swapping of genetic material between homologous DNA molecules?

    <p>Homologous recombination</p> Signup and view all the answers

    Which stage of meiosis does homologous recombination occur in eukaryotes?

    <p>Prophase I</p> Signup and view all the answers

    Which type of mutation results in the translation being stopped early due to a stop codon?

    <p>Nonsense</p> Signup and view all the answers

    Which type of mutation results in a triplet code that still codes for the same amino acid?

    <p>Silent</p> Signup and view all the answers

    Which mechanism of DNA repair is likely to involve kinase and BRCA1?

    <p>Nonhomologous end joining</p> Signup and view all the answers

    Which hypothesis suggests that mutations arise from adaptations to the environment?

    <p>Adaptation hypothesis</p> Signup and view all the answers

    Which type of mutation involves the replacement of one pyrimidine by another?

    <p>Transition</p> Signup and view all the answers

    Which type of mutation involves the replacement of a pyrimidine by a purine or vice versa?

    <p>Transversion</p> Signup and view all the answers

    What type of mutation can be caused by the addition of bulky adducts?

    <p>Frameshift mutation</p> Signup and view all the answers

    How do hydroxylating agents cause mutations?

    <p>By adding hydroxyl groups to bases</p> Signup and view all the answers

    What type of damage can be caused by transposable DNA elements?

    <p>All of the above</p> Signup and view all the answers

    What type of radiation can produce reactive oxygen molecules that damage DNA?

    <p>Ionizing radiation</p> Signup and view all the answers

    What is the role of activator proteins in transcriptional regulation?

    <p>They bind regulatory sequences to stimulate transcription</p> Signup and view all the answers

    What is the role of repressor proteins in transcriptional regulation?

    <p>They bind other sequences to stop or slow transcription</p> Signup and view all the answers

    What is a characteristic of enhancers and silencers in eukaryotes?

    <p>They are non-coding DNA regions</p> Signup and view all the answers

    What is the purpose of the Ames test?

    <p>To determine if a chemical can cause DNA mutations in bacteria</p> Signup and view all the answers

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