DNA Alterations in Aging and Cancer

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Questions and Answers

What is one potential outcome of genetic and epigenetic alterations in DNA?

  • Increased protein synthesis
  • Altered gene expression (correct)
  • Enhanced immune response
  • Reversal of aging effects

Which of the following best describes the relationship between aging and cancer malignancies in terms of DNA changes?

  • Aging decreases the likelihood of malignancies.
  • Both involve similar types of DNA alterations. (correct)
  • Malignancies are exclusively caused by environmental factors.
  • Only aging is associated with genetic changes.

What do genetic alterations specifically refer to in the context of DNA changes?

  • Modifications that affect DNA structure without changing the sequence.
  • Changes in the actual nucleotide sequence of DNA. (correct)
  • Temporary modifications that revert over time.
  • Changes that improve cellular function.

What role do epigenetic alterations play in gene expression?

<p>They influence gene expression without altering the DNA sequence. (A)</p> Signup and view all the answers

Which statement is true regarding the effects of aging on DNA?

<p>Aging can result in genetic and epigenetic modifications. (C)</p> Signup and view all the answers

Flashcards

Aging

The process of becoming older, leading to biological changes.

Cancer malignancies

Aggressive tumors that invade healthy tissues and spread.

Genetic alterations

Changes in the DNA sequence of an organism.

Epigenetic alterations

Changes that affect gene activity without altering DNA sequence.

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Altered gene expression

Changes in the levels of gene transcription and translation.

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Study Notes

  • Aging and cancer malignancies both induce changes in DNA
  • These changes involve both genetic and epigenetic alterations
  • Genetic alterations are modifications to the DNA sequence itself
  • Epigenetic alterations affect gene expression without changing the DNA sequence
  • Examples of epigenetic alterations include DNA methylation and histone modifications
  • These DNA alterations result in changes in gene expression
  • Altered gene expression can lead to various cellular abnormalities and contribute to disease
  • Changes in gene expression are critical in the progression of aging and cancer
  • Disease processes often involve aberrant gene expression patterns
  • The specific genes affected and the extent of the alterations vary depending on the individual and the disease
  • Understanding the complex interplay between DNA alterations and gene expression is crucial for developing targeted therapies for age-related and cancer-related diseases
  • Further research is necessary to fully understand the mechanisms behind these alterations and how they contribute to these diseases

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