Chapter 9-5

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Questions and Answers

A patient with a chronic, non-healing wound is suspected of having a systemic factor impairing their healing. Which of the following systemic conditions would most likely contribute to this dysfunctional wound healing?

  • Hypertension controlled with a low-sodium diet.
  • Osteoarthritis managed with occasional NSAIDs.
  • Type 2 diabetes with consistently elevated blood glucose levels. (correct)
  • Well-managed hypothyroidism with stable hormone levels.

A patient develops a severe allergic reaction after a bee sting, displaying symptoms such as difficulty breathing, hives, and a drop in blood pressure. Which of the following physiological events is the primary driver of these symptoms in this immediate hypersensitivity reaction?

  • Activation of cytotoxic T-cells leading to direct tissue damage.
  • Release of histamine and other mediators from mast cells due to IgE antibody binding. (correct)
  • Antibody-mediated destruction of cells, such as red blood cells or platelets.
  • Formation of immune complexes that deposit in tissues, causing inflammation.

A patient with a known autoimmune disorder is experiencing a flare-up of symptoms, including joint pain and fatigue. Which of the following best describes the underlying mechanism of autoimmune diseases?

  • A deficient immune response resulting in increased susceptibility to infections.
  • An allergic reaction to environmental triggers causing inflammation and tissue damage.
  • The immune system attacking the body's own tissues and cells. (correct)
  • An overactive immune response to external pathogens, leading to collateral tissue damage.

A newborn presents with hypotonia, feeding difficulties, and a weak cry. The mother has a history of myasthenia gravis. Which of the following best explains the likely cause of the newborn's symptoms?

<p>Maternal antibodies against acetylcholine receptors crossed the placenta, causing transient muscle weakness in the newborn. (C)</p> Signup and view all the answers

A patient undergoing a bone marrow transplant requires careful monitoring for signs of immune dysfunction. Which of the following complications is a potential consequence of a bone marrow transplant related to immune function?

<p>Graft-versus-host disease (GVHD), where the donor immune cells attack the recipient's tissues. (B)</p> Signup and view all the answers

A researcher is investigating potential causes for the increased incidence of autoimmune diseases in women compared to men. Which of the following factors is most likely to contribute to this disparity?

<p>Hormonal differences between men and women can influence immune system function. (C)</p> Signup and view all the answers

A patient with a deep, infected wound is healing by secondary intention. Which of the following characteristics is most likely to be observed in this patient's wound healing process compared to healing by primary intention?

<p>Prolonged inflammatory phase and more pronounced scar formation. (A)</p> Signup and view all the answers

A patient is diagnosed with a deficiency in IgA. While many individuals with this condition are asymptomatic, what potential clinical manifestation could they experience due to this specific immunodeficiency?

<p>Increased risk of bacterial infections, particularly chronic sinus infections. (C)</p> Signup and view all the answers

A researcher is studying the pathogenesis of rheumatoid arthritis. Which of the following pathological processes is primarily involved in the joint damage seen in this autoimmune disease?

<p>Autoantibody-mediated inflammation of the synovium, leading to cartilage and bone damage. (D)</p> Signup and view all the answers

A public health official is analyzing health data to understand disease patterns in a community. Which of the following measures provides information about the number of new cases of a disease occurring within a specific population over a defined period?

<p>Incidence. (E)</p> Signup and view all the answers

Flashcards

Wound Healing: Primary Intention

Occurs in clean wounds with closely opposed margins, leading to quicker healing with minimal scarring.

Wound Healing: Secondary Intention

Occurs in large, gaping, or infected wounds; healing is prolonged with pronounced scarring.

Hypersensitivity

An excessive immune response to a substance (allergen, etc.).

Autoimmunity

Immune reactions directed against one's own tissues.

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Isoimmunity

Antibodies or T-cells formed against antigens on another person's cells.

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Type 1 Hypersensitivity

Immediate hypersensitivity reaction involving IgE antibodies; causes vasodilation, mucus production, and bronchoconstriction.

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Type 2 Hypersensitivity

Hypersensitivity where IgG or IgM antibodies bind to cell membranes, leading to cell destruction.

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Type 3 Hypersensitivity

Hypersensitivity caused by immune complexes of IgG antibodies and antigens, leading to inflammation and tissue injury.

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Type 4 Hypersensitivity

Delayed hypersensitivity mediated by T-cells, causing inflammation and cytotoxicity.

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Immunodeficiency

Inadequate immune system function leading to increased susceptibility to infections.

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