Diuretics and Cardiovascular Medications Quiz

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Questions and Answers

Which type of diuretic works by slowing down or turning off the salt pumps in nephron tubes farthest from capillaries?

  • Thiazide diuretics (correct)
  • ACE Inhibitors
  • Potassium-sparing diuretics
  • Loop diuretics

What is a potential adverse effect of Thiazide diuretics?

  • Photosensitivity
  • Angioedema
  • Hypokalemia (correct)
  • Ototoxicity

Which of the following is NOT a side effect of Loop diuretics?

  • Ototoxicity
  • Photosensitivity
  • Hyperglycemia
  • Hypokalemia (correct)

Which type of diuretic is most likely to cause hyperkalemia?

<p>Potassium-sparing diuretics (C)</p> Signup and view all the answers

What is a common side effect of ACE inhibitors?

<p>Persistent dry cough (D)</p> Signup and view all the answers

Which of the following medications is NOT a type of ACE inhibitor?

<p>Valsartan (D)</p> Signup and view all the answers

What is a potential adverse effect of Angiotensin II Receptor Blockers (ARBs)?

<p>Angioedema (D)</p> Signup and view all the answers

Which type of medication is most likely to cause Stevens-Johnson syndrome?

<p>Calcium Channel Blockers (A)</p> Signup and view all the answers

What is the main mechanism of action of Calcium Channel Blockers?

<p>Blocking Ca+ from entering muscle cells (A)</p> Signup and view all the answers

Which of the following medications is a Beta Blocker?

<p>Metoprolol (C)</p> Signup and view all the answers

Which type of medication works by stimulating bone marrow to increase production of red blood cells and/or platelets?

<p>Colony-Stimulating Agents (D)</p> Signup and view all the answers

Which of these is NOT a known side effect of fibrates?

<p>Increased risk of gout (A)</p> Signup and view all the answers

What is the mechanism of action for Warfarin?

<p>Interferes with vitamin K synthesis (B)</p> Signup and view all the answers

Which medication type can safely be used during pregnancy?

<p>Thrombin Inhibitors (B)</p> Signup and view all the answers

What is a potential adverse effect of Nicotinic Acid Agents?

<p>Gout (B)</p> Signup and view all the answers

What is the primary effect of Aspirin on the body?

<p>Inhibits platelet aggregation (A)</p> Signup and view all the answers

Which of the following medication types can increase the effectiveness of Warfarin?

<p>Fibrates (C)</p> Signup and view all the answers

Which of the following is NOT a known side effect of Heparin?

<p>Gout (D)</p> Signup and view all the answers

Which medication type works by directly and indirectly blocking thrombin activation?

<p>Thrombin Inhibitors (A)</p> Signup and view all the answers

Which medication type is used to dissolve existing blood clots for conditions like heart attacks, strokes, and embolism?

<p>Thrombolytic Drugs (C)</p> Signup and view all the answers

What is the primary effect of Absorption Inhibitors on cholesterol levels in the body?

<p>Decrease LDL levels (A)</p> Signup and view all the answers

What is the primary role of Nicotinic Acid Agents (Niacin) in cholesterol management?

<p>Increase HDL levels (A)</p> Signup and view all the answers

What is a potential side effect of taking Fibrates, specifically Gemfibrozil, in combination with Statins?

<p>Higher blood levels of statins (D)</p> Signup and view all the answers

Which of these drugs is NOT an example of a Thrombin Inhibitor?

<p>Aspirin (C)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with Warfarin?

<p>Bleeding (D)</p> Signup and view all the answers

What is the primary mechanism of action of beta blockers, such as metoprolol?

<p>Block the effects of norepinephrine and epinephrine on the heart (C)</p> Signup and view all the answers

Which of the following medications is a direct vasodilator used for managing high blood pressure?

<p>Hydralazine (D)</p> Signup and view all the answers

Which drug class is known to slow the heart rate by blocking the action of the vagus nerve?

<p>Atropine (B)</p> Signup and view all the answers

What is the mechanism of action of the cardiac glycoside, digoxin, in treating heart failure?

<p>Decrease heart rate and increase contractility (C)</p> Signup and view all the answers

Which of the following medications is a positive inotrope, increasing heart contractility and cardiac output?

<p>Dobutamine (C)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with alpha blockers?

<p>Dizziness (B)</p> Signup and view all the answers

Which of the following drugs is a central-acting adrenergic agent used to treat hypertension?

<p>Clonidine (C)</p> Signup and view all the answers

Which of the following is a common side effect of digoxin?

<p>Bradycardia (A)</p> Signup and view all the answers

Which of the following drugs is a human B-type natriuretic peptide, primarily used for treating acute decompensated heart failure?

<p>Nesiritide (D)</p> Signup and view all the answers

Which of the following is a common side effect associated with the use of human B-type natriuretic peptides?

<p>Dizziness (C)</p> Signup and view all the answers

Which of the following drug classes is known to decrease the excitability of the heart by blocking sodium channels?

<p>Class IA Sodium Channel Blockers (B)</p> Signup and view all the answers

Which of the following medications is a potassium channel blocker?

<p>Sotalol (B)</p> Signup and view all the answers

Which of the following is a potential life-threatening adverse effect associated with the use of potassium and magnesium?

<p>Ventricular fibrillation (D)</p> Signup and view all the answers

Which of the following agents is often used to treat bradycardia and some types of asystole?

<p>Atropine (C)</p> Signup and view all the answers

Which of the following drugs is NOT a beta blocker?

<p>Clonidine (A)</p> Signup and view all the answers

What is the primary action of bile acid sequestrants?

<p>Help the body lose cholesterol (C)</p> Signup and view all the answers

What should patients do to minimize gastrointestinal discomfort when taking bile acid sequestrants?

<p>Take the tablet with at least 12 to 16 oz of water (D)</p> Signup and view all the answers

What adverse effect is associated with the use of bile acid sequestrants?

<p>GI distress (C)</p> Signup and view all the answers

What effect do bile acid sequestrants have on anticoagulants like warfarin?

<p>They decrease vitamin K absorption (C)</p> Signup and view all the answers

Which of the following is an example of a cholesterol-reducing agent?

<p>Ezetimibe (C)</p> Signup and view all the answers

What mechanism do bile acid sequestrants employ to lower blood lipid levels?

<p>Bind cholesterol in the intestine (C)</p> Signup and view all the answers

What is a potential result of prolonged use of bile acid sequestrants?

<p>Reduced cholesterol levels (B)</p> Signup and view all the answers

Which of these side effects is NOT commonly associated with bile acid sequestrants?

<p>Skin rash (B)</p> Signup and view all the answers

How do bile acid sequestrants affect the intestines?

<p>Decrease bile acid recycling (B)</p> Signup and view all the answers

What is the main benefit of integrating bile acid sequestrants in treatment regimens?

<p>Lowered blood lipid levels (C)</p> Signup and view all the answers

What is a primary use of Class 4 Calcium Channel Blockers?

<p>To treat ventricular tachycardia (D)</p> Signup and view all the answers

Which effect is associated with adenosine when administered IV?

<p>Restores normal sinus rhythm (C)</p> Signup and view all the answers

What adverse effect is commonly associated with magnesium sulfate?

<p>Diarrhea (B)</p> Signup and view all the answers

What mechanism does magnesium sulfate utilize to prevent torsades de pointes?

<p>By preventing low magnesium levels (A)</p> Signup and view all the answers

Which statement best describes adenocard's mechanism of action?

<p>Slows down conduction through AV node (C)</p> Signup and view all the answers

What is a common side effect of statin medications?

<p>Rhabdomyolysis (C)</p> Signup and view all the answers

Which drug class is most commonly prescribed for managing hyperlipidemia?

<p>Statins (B)</p> Signup and view all the answers

What should be avoided when administering adenosine?

<p>Using it post-defibrillation too soon (C)</p> Signup and view all the answers

Which drug is an example of a Class 4 antiarrhythmic agent?

<p>Diltiazem (B)</p> Signup and view all the answers

For what condition is adenosine MOST commonly used?

<p>Supraventricular tachycardia (SVT) (A)</p> Signup and view all the answers

What is the main effect of Class 4 Calcium Channel Blockers on heart function?

<p>Decrease heart rate (B)</p> Signup and view all the answers

What is a potential consequence of high doses of magnesium in the body?

<p>Cardiac arrest (D)</p> Signup and view all the answers

In treating atrial fibrillation, what is the goal of therapy?

<p>To convert to normal sinus rhythm (C)</p> Signup and view all the answers

Which side effect is NOT commonly reported for statins?

<p>Increased libido (C)</p> Signup and view all the answers

Flashcards

Loop Diuretics

Powerful diuretics that inhibit Na+ pumps in the Loop of Henle.

Furosemide

A loop diuretic causing photosensitivity and ototoxicity.

Thiazide Diuretics

Diuretics that work on nephron tubes, reducing blood volume and BP.

Chlorothiazide

A thiazide diuretic with side effects like hypokalemia and dizziness.

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Potassium-sparing Diuretics

Prevent potassium loss while promoting sodium and water excretion.

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Spironolactone

A potassium-sparing diuretic that can cause hirsutism in women.

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ACE Inhibitors

Drugs that block angiotensin II production to lower BP.

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Lisinopril

An ACE inhibitor associated with cough and angioedema.

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Angiotensin II Receptor Blockers (ARBs)

Block the effects of angiotensin II, leading to vasodilation.

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Calcium Channel Blockers

Prevent calcium from entering muscle cells, decreasing heart contraction strength.

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Bile Acid Sequestrants

A class of drugs that help lower cholesterol levels by binding bile acids in the intestine.

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Lower Blood Lipid Levels

The goal of bile acid sequestrants and cholesterol-lowering medications to reduce lipids in the bloodstream.

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Mechanism of Action

The way a drug works, particularly how it binds substances in the body.

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Cholesterol Binding

The action of bile acid sequestrants that binds cholesterol in the intestine to prevent absorption.

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Examples of Bile Acid Sequestrants

Drugs like Colestipol and Cholestyramine that help lower cholesterol.

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Patient Instructions

Patients should take bile acid sequestrants with plenty of water to aid in effectiveness.

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Gastrointestinal Side Effects

Possible discomfort or constipation experienced by patients taking bile acid sequestrants.

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Vitamin K Absorption

Bile acid sequestrants can decrease the absorption of Vitamin K, affecting blood clotting.

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Warfarin Interaction

Bile acid sequestrants may change the action of anticoagulants like warfarin.

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Cholesterol Reduction

The primary effect of drugs like Ezetimibe that lower cholesterol levels.

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Class 4 Calcium Channel Blockers

Medications that treat supraventricular tachycardia by slowing conduction through the AV node.

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Diltiazem

A Class 4 calcium channel blocker used to manage supraventricular tachycardia.

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Verapamil

Another Class 4 calcium channel blocker for supraventricular tachycardia treatment.

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Adenosine

Medication given intravenously to treat supraventricular tachycardia by temporarily slowing the heart rate.

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Mechanism of Adenosine

Works by slowing impulse through the AV node to restore normal heart rhythm.

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Magnesium Sulfate

Used intravenously to prevent torsades de pointes and treat low magnesium levels.

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Calcium Channel Blockers Effect

Slow conduction through SA and AV nodes, decreasing heart rate.

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Ventricular Tachycardia

A fast heart rhythm originating from the ventricles that can be life-threatening.

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Side Effects of Adenosine

Facial flushing, shortness of breath, and transient dysrhythmias may occur.

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Statins

Medications that lower cholesterol levels in the blood by inhibiting HMG-CoA reductase.

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Common Statins

Examples include Atorvastatin, Lovastatin, and Fluvastatin.

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Statins and Muscle Pain

Potential side effect includes muscle pain and rhabdomyolysis.

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Torsades de Pointes

A specific type of ventricular tachycardia often triggered by low magnesium levels.

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IV Magnesium Use

Administered to prevent and treat torsades de pointes and other arrhythmias.

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Decreased Heart Rate

A possible effect of adenosine and calcium channel blockers.

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Zetia

A medication that inhibits cholesterol absorption in the intestines.

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Fibrates

Drugs that activate lipid receptors to lower triglycerides.

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Niacin

A vitamin that reduces triglycerides and raises HDL cholesterol levels.

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Thrombin Inhibitors

Drugs that block the action of thrombin to prevent blood clots.

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Warfarin

An anticoagulant that interferes with Vitamin K to prevent clot formation.

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Aspirin

An antiplatelet drug that prevents platelet aggregation.

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Thrombolytics

Drugs used to dissolve existing clots during heart attacks or strokes.

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Colony-Stimulating Factors

Agents that stimulate the production of blood cells in bone marrow.

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HDL Cholesterol

High-density lipoprotein, known as 'good' cholesterol, which helps remove other forms of cholesterol.

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LDL Cholesterol

Low-density lipoprotein, known as 'bad' cholesterol, which can lead to plaque buildup in arteries.

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Triglycerides

A type of fat found in the blood, high levels can increase heart disease risk.

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Creatinine

A waste product from muscle metabolism, often measured to assess kidney function.

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Side Effects of Statins

Common side effects include muscle pain and liver enzyme changes.

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Heparin

An anticoagulant that helps prevent blood clots from forming.

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Alpha Blockers

Medications that relax blood vessels by blocking alpha-adrenergic receptors, leading to lower blood pressure.

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Beta Blockers

Drugs that reduce heart rate and force of contraction by blocking beta-adrenergic receptors, often ending in '-olol'.

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Digoxin

A cardiac glycoside used to strengthen heart contractions and slow down the heart rate in heart failure.

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Central Acting Adrenergic Agents

Medications that stimulate CNS receptors to decrease blood vessel constriction and lower blood pressure.

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Direct Vasodilators

Medications that directly relax blood vessels, lowering blood pressure and often used in hypertensive emergencies.

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Positive Inotropes

Drugs that increase the strength of heart contractions and cardiac output, often used in heart failure.

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Class IA Sodium Channel Blockers

Antiarrhythmic drugs that inhibit sodium movement, used to treat various tachyarrhythmias.

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Class IB Sodium Channel Blockers

Antiarrhythmics that decrease the number of electrical impulses, often used for ventricular arrhythmias.

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Class IC Sodium Channel Blockers

Powerful antiarrhythmic agents that block sodium channels more than Class IA and IB, used for life-threatening arrhythmias.

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Class III Potassium Channel Blockers

Medications that block potassium channels to prolong action potential and are used to treat arrhythmias.

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Nesiritide

A B-type natriuretic peptide that promotes diuresis and vasodilation, used in heart failure management.

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Atropine

A medication that blocks vagal effects on the heart to increase heart rate, used in bradycardia.

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Hydralazine

A direct vasodilator that decreases blood pressure by relaxing the arteries.

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Lidocaine

A Class IB antiarrhythmic that is effective in treating ventricular tachycardia and stabilizing the heart.

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Clonidine

A central acting agent that stimulates alpha-2 receptors to lower blood pressure and decrease heart rate.

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Study Notes

Diuretics

  • Loop diuretics (e.g., furosemide) are the most powerful, inhibiting sodium pumps in the loop of Henle, causing increased loss of sodium, potassium, calcium, and water.
  • Thiazide diuretics (e.g., chlorothiazide, metolazone) inhibit sodium pumps in the distal convoluted tubule, reducing blood volume and blood pressure.
  • Potassium-sparing diuretics (e.g., spironolactone, amiloride) reduce potassium loss, maintaining levels within a healthy range.

ACE Inhibitors

  • ACE inhibitors (e.g., lisinopril, enalapril) block the production of angiotensin II, a hormone that constricts blood vessels, relaxing blood vessels and decreasing water.

Angiotensin II Receptor Blockers (ARBs)

  • ARBs (e.g., valsartan, losartan) block the effects of angiotensin II, reducing vasoconstriction and sodium/water retention.

Calcium Channel Blockers

  • Calcium channel blockers (e.g., amlodipine, verapamil) block calcium entering muscle cells, reducing the strength of heart contractions and dilating arteries.
  • Class 2 Beta Blockers (e.g., metoprolol, atenolol, acebutolol), block the effects of epinephrine, reducing heart rate and force of contraction.

Alpha Blockers

  • Alpha blockers (e.g., carvedilol, labetalol) block norepinephrine effects, leading to artery relaxation and dilation.

Alpha-Beta Blockers

  • Alpha-beta blockers (e.g., carvedilol, labetalol) relax blood vessels and slow heart rate and the force of contraction.

Central-Acting Adrenergic Agents

  • Central-acting adrenergic agents (e.g., clonidine, methyldopa) stimulate CNS receptors to constrict blood vessel flow, thereby decreasing it.

Direct Vasodilators

  • Direct vasodilators (e.g., hydralazine) dilate peripheral arteries, lowering blood pressure.

Cardiac Glycosides (Digoxin)

  • Cardiac glycosides (e.g., digoxin) slow heart rate, strengthen heartbeat, and improve cardiac output.

Human B-type Natriuretic Peptides

  • Human B-type Natriuretic Peptides (e.g., nesiritide) eliminate excessive sodium and water, decreasing blood pressure.
  • Positive inotropes (e.g., dobutamine, dopamine) increase heart contraction and cardiac output.

Potassium & Magnesium

  • Potassium and magnesium are essential for a healthy nervous system, and regulate heart rhythm.
  • Potassium sparing diuretics can maintain potassium levels.

Other Drugs

  • Colony-Stimulating Agents stimulate bone marrow to increase the production of red blood cells or platelets, improving clotting ability.
  • Thrombolytics dissolve existing clots for heart attacks, strokes, or emboli.
  • Thrombin inhibitors stop the action of thrombin, preventing clot formation.
  • Clotting factor synthesis inhibitors (e.g., warfarin) interfere with vitamin K synthesis, decreasing clot formation.
  • Antiplatelet drugs (e.g., aspirin) block platelet aggregation, preventing clot formation.

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