Questions and Answers
What drug class is disulfiram in?
What are the contraindications of disulfiram?
Hypersensitivity to drug or other thiuram derivatives; psychoses; myocardial disease; coronary occlusion; interaction with metronidazole, alcohol; intoxication; and specific conditions like diabetes mellitus.
Which of the following are drug-drug interactions with disulfiram? (Select all that apply)
What is the mechanism of action of disulfiram?
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What are the therapeutic effects of disulfiram?
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Which of the following are side effects of alprazolam? (Select all that apply)
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What are the adverse reactions of disulfiram?
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Study Notes
Disulfiram Overview
- Disulfiram is classified as an alcohol deterrent used to treat alcohol dependence.
Contraindications
- Contraindicated for individuals with hypersensitivity to disulfiram or related thiuram derivatives.
- Not recommended for patients with psychoses, myocardial disease, or coronary occlusion.
- Should not be used in conjunction with metronidazole, alcohol, or any alcohol-containing products.
- Avoid disulfiram in individuals who are currently intoxicated or have consumed alcohol within the last 12 hours.
- Use caution in patients undergoing phenytoin therapy and those with diabetes, hypothyroidism, seizure disorders, cerebral damage, nephritis, or liver issues, due to risk of disulfiram-alcohol reactions.
Drug-Drug Interactions
- Significant interactions can occur with isoniazid, phenytoin, tricyclic antidepressants (TCA's), and theophylline.
Mechanism of Action
- Disulfiram works by inhibiting the oxidation of alcohol at the acetaldehyde stage.
- The accumulation of acetaldehyde leads to unpleasant reactions with even minor alcohol consumption, deterring the use of alcohol.
Therapeutic Effects
- Primarily aims to assist individuals in overcoming alcohol addiction.
Side Effects
- Common side effects include headache, fatigue, restlessness, erectile dysfunction, hepatic failure, and drowsiness.
Adverse Reactions
- Adverse effects may include drowsiness, fatigue, impotence, headache, peripheral neuritis, and a distinctive metallic or garlic-like taste, which generally decrease after approximately two weeks of treatment.
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Description
Test your knowledge on disulfiram and its drug class with these flashcards. Learn about contraindications and the context in which disulfiram is used as an alcohol deterrent. Perfect for students or professionals in pharmacy or medicine.
