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Diseases Related to GI Motility and Drugs to Treat Them

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Diseases Related to GI Motility and Drugs to Treat Them

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Questions and Answers

Which condition is characterized by the inability of the lower esophageal sphincter to relax and the loss of peristalsis in the esophagus?

GERD

Colonic pseudo-obstruction

Achalasia (correct)

Gastroparesis

What is the condition where feces accumulates in the colon due to a lack of passage through it?

Achalasia

Colonic pseudo-obstruction (correct)

Gastroparesis

GERD

Which medication binds to and activates muscarinic ACh M3 receptors, resulting in increased motility?

Bethanechol (correct)

Dopamine

Neostigmine

Metoclopramide

What is the mechanism of action of Neostigmine in treating decreased GI motility?

Inhibits acetylcholinesterase Signup and view all the answers

Which drug class is Metoclopramide classified under to treat GI motility disorders?

Dopamine receptor agonists Signup and view all the answers

What is one side effect associated with Bethanechol use for treating GI motility disorders?

Bradycardia Signup and view all the answers

What is the mechanism of action of metoclopramide?

It inhibits D2 receptors, preventing inhibition of cholinergic smooth muscle stimulation, leading to increased GI smooth muscle stimulation and peristalsis of the esophagus and stomach. Signup and view all the answers

What is the primary clinical use of metoclopramide?

Treating patients with gastroparesis (delayed gastric emptying) associated with diabetes or postsurgical disorders. Signup and view all the answers

Which class of antibiotics stimulates motilin receptors on gastrointestinal smooth muscle, promoting peristalsis?

Macrolides Signup and view all the answers

According to the Bristol Stool Chart, what is considered an ideal stool form?

Soft and smooth, like a sausage or snake Signup and view all the answers

Which of the following is NOT a type of laxative mentioned in the text?

Prokinetic agents Signup and view all the answers

What is the mechanism of action of bulk-forming laxatives?

They absorb water, forming a bulk that distends the colon and promotes peristalsis. Signup and view all the answers