Diseases Related to GI Motility and Drugs to Treat Them
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Questions and Answers

Which condition is characterized by the inability of the lower esophageal sphincter to relax and the loss of peristalsis in the esophagus?

  • GERD
  • Colonic pseudo-obstruction
  • Achalasia (correct)
  • Gastroparesis

What is the condition where feces accumulates in the colon due to a lack of passage through it?

  • Achalasia
  • Colonic pseudo-obstruction (correct)
  • Gastroparesis
  • GERD

Which medication binds to and activates muscarinic ACh M3 receptors, resulting in increased motility?

  • Bethanechol (correct)
  • Dopamine
  • Neostigmine
  • Metoclopramide

What is the mechanism of action of Neostigmine in treating decreased GI motility?

<p>Inhibits acetylcholinesterase (D)</p> Signup and view all the answers

Which drug class is Metoclopramide classified under to treat GI motility disorders?

<p>Dopamine receptor agonists (A)</p> Signup and view all the answers

What is one side effect associated with Bethanechol use for treating GI motility disorders?

<p>Bradycardia (A)</p> Signup and view all the answers

What is the mechanism of action of metoclopramide?

<p>It inhibits D2 receptors, preventing inhibition of cholinergic smooth muscle stimulation, leading to increased GI smooth muscle stimulation and peristalsis of the esophagus and stomach. (D)</p> Signup and view all the answers

What is the primary clinical use of metoclopramide?

<p>Treating patients with gastroparesis (delayed gastric emptying) associated with diabetes or postsurgical disorders. (C)</p> Signup and view all the answers

Which class of antibiotics stimulates motilin receptors on gastrointestinal smooth muscle, promoting peristalsis?

<p>Macrolides (A)</p> Signup and view all the answers

According to the Bristol Stool Chart, what is considered an ideal stool form?

<p>Soft and smooth, like a sausage or snake (A)</p> Signup and view all the answers

Which of the following is NOT a type of laxative mentioned in the text?

<p>Prokinetic agents (B)</p> Signup and view all the answers

What is the mechanism of action of bulk-forming laxatives?

<p>They absorb water, forming a bulk that distends the colon and promotes peristalsis. (C)</p> Signup and view all the answers

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