12 Questions
Which condition is characterized by the inability of the lower esophageal sphincter to relax and the loss of peristalsis in the esophagus?
Achalasia
What is the condition where feces accumulates in the colon due to a lack of passage through it?
Colonic pseudo-obstruction
Which medication binds to and activates muscarinic ACh M3 receptors, resulting in increased motility?
Bethanechol
What is the mechanism of action of Neostigmine in treating decreased GI motility?
Inhibits acetylcholinesterase
Which drug class is Metoclopramide classified under to treat GI motility disorders?
Dopamine receptor agonists
What is one side effect associated with Bethanechol use for treating GI motility disorders?
Bradycardia
What is the mechanism of action of metoclopramide?
It inhibits D2 receptors, preventing inhibition of cholinergic smooth muscle stimulation, leading to increased GI smooth muscle stimulation and peristalsis of the esophagus and stomach.
What is the primary clinical use of metoclopramide?
Treating patients with gastroparesis (delayed gastric emptying) associated with diabetes or postsurgical disorders.
Which class of antibiotics stimulates motilin receptors on gastrointestinal smooth muscle, promoting peristalsis?
Macrolides
According to the Bristol Stool Chart, what is considered an ideal stool form?
Soft and smooth, like a sausage or snake
Which of the following is NOT a type of laxative mentioned in the text?
Prokinetic agents
What is the mechanism of action of bulk-forming laxatives?
They absorb water, forming a bulk that distends the colon and promotes peristalsis.
Explore diseases related to decreased GI motility, such as achalasia, impaired gastric emptying, and acute large bowel distention. Learn about drug treatments for these conditions and their mechanisms of action.
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