Podcast
Questions and Answers
Who showed Watson the famous image known as Franklin's Photo 51?
Who showed Watson the famous image known as Franklin's Photo 51?
What did Franklin's X-ray crystallography data show about the symmetry of DNA?
What did Franklin's X-ray crystallography data show about the symmetry of DNA?
What did Chargaff's analysis of DNA chemical composition reveal?
What did Chargaff's analysis of DNA chemical composition reveal?
What challenge did Watson face when building models based on Crick's insight about the symmetry of DNA?
What challenge did Watson face when building models based on Crick's insight about the symmetry of DNA?
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What did the discovery of the double helix structure explain?
What did the discovery of the double helix structure explain?
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Who were the scientists that joined forces to discover the structure of the gene?
Who were the scientists that joined forces to discover the structure of the gene?
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Why was DNA often dismissed as the biological molecule involved in inheritance?
Why was DNA often dismissed as the biological molecule involved in inheritance?
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What hindered the partnership between Maurice Wilkins and Rosalind Franklin?
What hindered the partnership between Maurice Wilkins and Rosalind Franklin?
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Why did the Cavendish Lab director not want his equipment used for DNA analysis?
Why did the Cavendish Lab director not want his equipment used for DNA analysis?
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Which scientist was also working on DNA structure in California, causing concern for Watson and Crick?
Which scientist was also working on DNA structure in California, causing concern for Watson and Crick?
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What did Watson and Crick initially build a model of in 1951?
What did Watson and Crick initially build a model of in 1951?
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Who showed Watson the famous image known as Franklin's Photo 51?
Who showed Watson the famous image known as Franklin's Photo 51?
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What challenge did Watson face when building models based on Crick's insight about the symmetry of DNA?
What challenge did Watson face when building models based on Crick's insight about the symmetry of DNA?
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According to Chargaff's analysis of DNA chemical composition, what was always equal?
According to Chargaff's analysis of DNA chemical composition, what was always equal?
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What did the discovery of the double helix structure explain?
What did the discovery of the double helix structure explain?
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What technique was used to solve molecular structures, but the Cavendish Lab director did not want his equipment used for DNA analysis?
What technique was used to solve molecular structures, but the Cavendish Lab director did not want his equipment used for DNA analysis?
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What was the apparent reason for DNA being often dismissed as the biological molecule involved in inheritance?
What was the apparent reason for DNA being often dismissed as the biological molecule involved in inheritance?
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What did Maurice Wilkins and Rosalind Franklin conflict over when working on DNA structure at King's College?
What did Maurice Wilkins and Rosalind Franklin conflict over when working on DNA structure at King's College?
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Who was also working on DNA structure and caused concern for Watson and Crick, as they were worried he would solve the structure before them?
Who was also working on DNA structure and caused concern for Watson and Crick, as they were worried he would solve the structure before them?
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What molecular structure was believed to be made of either DNA or protein in the early 20th century?
What molecular structure was believed to be made of either DNA or protein in the early 20th century?
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Study Notes
- In the early 20th century, scientists were trying to unlock the secrets of inheritance and the biological molecule involved was yet to be discovered.
- James Watson, a 23-year-old American scientist, and Francis Crick, an Englishman trained as a physicist, joined forces in 1951 at the Cavendish Laboratory in Cambridge, England, to discover the structure of the gene.
- Watson was known for his love of science, determination, and unconventional behavior, while Crick was a quiet, thoughtful scientist with a strong interest in biology.
- The gene's structure was believed to be made of either DNA or protein, but DNA was often dismissed due to its apparent simplicity.
- X-ray crystallography was a powerful technique used to solve molecular structures, but the Cavendish Lab director did not want his equipment used for DNA analysis, as a group at King's College was already doing so.
- Maurice Wilkins and Rosalind Franklin were working on DNA structure at King's College. Wilkins wanted to lead the project, but Franklin believed it should be hers. Their conflicting goals hindered their partnership.
- Linus Pauling, a renowned physical chemist, was also working on DNA structure in California. Watson and Crick were concerned that he would solve the structure before them.
- In 1951, Watson and Crick built a model of DNA as a helix, but it was dismissed by Franklin due to inaccurate measurements provided by Watson.
- In January 1953, news came that Pauling was preparing a paper on DNA structure, and Watson rushed to London to find that Franklin was uninterested in his findings.
- Watson then encountered Wilkins, who showed him a famous image, Franklin's Photo 51, which revealed the helical structure of DNA. Watson immediately recognized its significance.- In the late 1940s and early 1950s, Watson and Crick were working on understanding the structure of DNA.
- Franklin's X-ray crystallography data showed the symmetry of DNA, leading Crick to the insight that the sugar phosphate backbones had to run in opposite directions.
- Watson started building models based on this new understanding, but faced a challenge when a colleague pointed out that the bases couldn't pair in the way Watson had proposed.
- Chargaff's analysis of DNA chemical composition revealed that the amounts of adenine (A) and thymine (T) in DNA were always equal, as were the amounts of guanine (G) and cytosine (C).
- Watson went to the lab on a Saturday morning and experimented with cardboard cutouts to create a model with complementary base pairing, which explained how genetic information is stored and how mutations occur.
- The structure of the double helix, revealed in 1953, explained both the stability of life and its mutability in evolution.
- The discovery of the double helix structure was celebrated around the world and led to a Nobel Prize nine years later.
- The discovery opened up a new world for biologists and paved the way for decoding the mysteries of life.
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Description
Test your knowledge about the discovery of the DNA double helix structure and the scientists involved, including James Watson, Francis Crick, Rosalind Franklin, and Maurice Wilkins. Learn about the events that led to one of the most significant breakthroughs in biology.
