Questions and Answers
What is the generic name for Dinoprostone (Cervidil)?
Which of these are trade names for Dinoprostone (Cervidil)?
What is the therapeutic class of Dinoprostone (Cervidil)?
Oxytocics
What is a primary indication for the use of Dinoprostone (Cervidil)?
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What is the recommended dosage for the Dinoprostone vaginal insert?
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How long should the patient lie down after using Dinoprostone gel?
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Dinoprostone produces strong contractions of uterine smooth muscle, possibly mediated by _____ and cAMP.
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The half-life of Dinoprostone is approximately 10 to 15 minutes.
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Which adverse reactions are associated with Dinoprostone?
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What should be avoided when using Dinoprostone with other oxytocics?
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The gel form of Dinoprostone is contraindicated in patients who are _____ to prostaglandins.
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What is the maximum dosage of Dinoprostone suppository within 24 hours?
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Study Notes
Dinoprostone (Cervidil) Overview
- Generic Name: Dinoprostone
- Trade Names: Cervidil, Prepidil, Prostin E2
Medication Classes
- Therapeutic Class: Oxytocics
- Pharmacologic Class: Prostaglandins
Indications for Use
- Used to ripen an unfavorable cervix in pregnant women at or near term
- Administration of the 10-mg vaginal insert occurs transversely in the posterior vaginal fornix
- Remove the insert at the onset of active labor or after 12 hours, whichever comes first
- Wait at least 30 minutes after removal before administering oxytocin
Dosages
- Vaginal Insert: 10-mg dose inserted transversely, to be removed after labor begins or 12 hours post-insertion
- Suppository: 20-mg inserted high into the posterior vaginal fornix; can repeat every 3 to 5 hours; maximum of 2 days until abortion is complete
- Endocervical Gel: 0.5 mg applied intravaginally; if no cervix change after 6 hours, can repeat up to a maximum of 1.5 mg within 24 hours
Administration
- Administered vaginally; considered hazardous—use safe handling practices
- Patient should rest in a supine position for 10-30 minutes post-administration
- Gel needs to be warmed to room temperature, but not through external heat sources
- Store vaginal suppository in the freezer and gel in the refrigerator
Action
- Induces strong contractions in uterine smooth muscle, potentially through mediation by calcium and cAMP
- Provides local effects on the cervix, promoting softening and dilation
- Half-life: 2.5 to 5 minutes
- Route Onset: Vaginal gel shows effects within unknown times; vaginal insert releases 0.3 mg/hr over 12 hr; suppository acts within 10 minutes
Adverse Reactions
- Cardiovascular: Arrhythmias, chest pain
- Gynecological: Vaginal pain, endometritis, uterine hyperstimulation
- Other: Shivering, chills, breast tenderness, fetal heart rate abnormalities
- Risks include premature rupture of membranes and fetal depression
Interactions
- Combined use with other oxytocics may enhance oxytocic effects; should be avoided
Contraindications & Cautions
- Contraindicated for those hypersensitive to prostaglandins
- Not suitable for patients with placenta previa, vaginal bleeding, or certain active infections
- Use in the presence of acute pelvic inflammatory disease, or significant patient comorbidities (cardiac, pulmonary, renal, or hepatic disease) is not recommended
- Not to be used once fetal viability is established
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Description
Test your knowledge on Dinoprostone, commonly known as Cervidil. These flashcards cover important information including generic names, medication classes, and indications for use. Perfect for students in pharmacology or medicine who need to learn about this specific medication.
