11 Diarrhea in Foals NOTES

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Questions and Answers

In a foal presenting with diarrhea, what is the primary justification for performing a full colic evaluation?

  • To assess the foal's hydration status and electrolyte balance.
  • To rule out the presence of severe gastrointestinal compromise, such as a strangulating lesion. (correct)
  • To identify the specific infectious agent causing the diarrhea.
  • To determine the extent of intestinal inflammation and mucosal damage.

What is the rationale behind the recommendation to avoid dry lots when trying to prevent diarrhea in foals?

  • Dry lots can become heavily contaminated with pathogens, increasing the risk of exposure to infectious agents. (correct)
  • Dry lots often lack sufficient drainage, leading to the accumulation of stagnant water and bacterial overgrowth.
  • Dry lots typically have poor ventilation, creating an environment conducive to the spread of airborne pathogens.
  • Dry lots tend to have higher concentrations of parasitic larvae, increasing the risk of parasitic infections.

Why is E. coli generally not considered a primary cause of diarrhea in foals, despite its potential presence?

  • _E. coli_ is effectively neutralized by the antibodies present in the mare's colostrum, limiting its ability to cause diarrhea in foals.
  • _E. coli_ is primarily a commensal organism in foals and only causes diarrhea in immunocompromised individuals.
  • Foals develop a natural immunity to _E. coli_ during the first few weeks of life, preventing it from causing significant diarrhea.
  • _E. coli_ is more likely to cause systemic infections such as sepsis and bacteremia, rather than direct gastrointestinal disease. (correct)

A foal is diagnosed with diarrhea caused by Clostridioides difficile. Which aspect of this disease's etiology in foals differentiates it from its presentation in adult horses?

<p>The presence of antimicrobial treatment history. (D)</p> Signup and view all the answers

What is the significance of identifying both the toxin and isolating the organism from feces when diagnosing Clostridioides difficile in foals with diarrhea?

<p>Isolating the organism confirms its presence, while toxin identification rules out other potential causes of diarrhea since the organism can be found in healthy individuals. (A)</p> Signup and view all the answers

What differentiates C. perfringens type A from type C in foals regarding the severity and treatment response of diarrhea?

<p>Type A is commonly isolated from healthy foals and causes moderate diarrhea with a good response to treatment, while type C causes severe hemorrhagic diarrhea with a poor response to treatment. (B)</p> Signup and view all the answers

What is the most critical reason for implementing isolation protocols for foals diagnosed with rotavirus or Clostridium species-related diarrhea?

<p>To minimize environmental contamination and the spread of infection to other susceptible foals. (A)</p> Signup and view all the answers

What is the underlying mechanism leading to osmotic diarrhea in foals with nutritional diarrhea?

<p>Dietary mistakes overwhelming the small intestine's digestive capacity and causing lactose fermentation in the hindgut. (B)</p> Signup and view all the answers

What is the primary mechanism of action of biosponge in the treatment of diarrhea in foals?

<p>Binding endotoxins and exotoxins to reduce their systemic effects. (A)</p> Signup and view all the answers

How does Lawsonia intracellularis cause diarrhea and protein loss in weanling foals, and what is a key clinical sign associated with this?

<p>By infecting the ileal epithelium, causing hyperplasia of crypt cells and malabsorptive diarrhea, with hypoalbuminemia as a key sign. (C)</p> Signup and view all the answers

What is the significance of detecting concurrent bacteremia in foals with severe, watery diarrhea and septic shock?

<p>Bacteremia indicates a systemic spread of infection and increases the severity and potential complications of the disease. (B)</p> Signup and view all the answers

Why are foals more susceptible to Salmonella infections between 12 hours and 4 months of age?

<p>The GI flora is not fully established which makes it easier to overcolonize. (B)</p> Signup and view all the answers

What is the primary reason broad-spectrum antibiotics are used to treat Salmonella infections in foals, contrasting with the approach in adult horses?

<p>Foals are more susceptible to bacteremia and systemic spread of infection due to their less mature immune systems. (A)</p> Signup and view all the answers

Why is washing the mare's udder recommended as part of the prevention strategy for diarrhea in foals?

<p>Washing the udder removes potential pathogens that could infect the foal during nursing, reducing the risk of diarrhea. (D)</p> Signup and view all the answers

Besides supportive care, what specific therapeutic intervention is often used to treat coronavirus infections in foals?

<p>Typically only supportive care, unless there is coinfection. (A)</p> Signup and view all the answers

What is the rationale for using lactase in the treatment of diarrhea in foals?

<p>To aid in lactose digestion, particularly in cases of rotavirus. (C)</p> Signup and view all the answers

How does the use of hyperimmune plasma in treating C. perfringens and C. difficile infections in foals potentially improve outcomes, and what factors should be considered when using this treatment?

<p>Hyperimmune plasma introduces targeted antibodies to neutralize bacterial toxins, reducing disease severity. Availability and cost are key considerations. (A)</p> Signup and view all the answers

Why is monitoring daily body weights important in foals with diarrhea undergoing fluid therapy, what is the most important to consider in relation to this?

<p>To assess the effectiveness of fluid therapy and adjust treatment based on changes in body weight. (A)</p> Signup and view all the answers

In a foal with diarrhea, what is the primary goal of fluid therapy beyond simply correcting dehydration?

<p>To restore circulating volume, improve tissue and organ perfusion, and correct electrolyte and acid-base abnormalities. (C)</p> Signup and view all the answers

A farm has a history of endemic rotavirus outbreaks in foals. What preventative measure involving the mare would be most effective in providing passive immunity to the foal?

<p>Administering MLV vaccine to the mare during the 8th, 9th and 10th month of pregnancy. (A)</p> Signup and view all the answers

Flashcards

Diarrhea in Foals

A frequent problem in foals where up to 80% experience an episode before 6 months of age.

Diarrhea as an indicator

Severe gastrointestinal tract involvement, indicating possible strangulation.

Foal Heat Diarrhea

Occurs in first 1-2 weeks, linked to GI flora development. Usually mild and needs minimal treatment.

Nutritional Diarrhea

Caused by dietary mistakes leading to osmotic issues. Typically mild and corrected with diet changes.

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Infectious Diarrhea

More severe, with 50% of foals bacteremic. Pathogens often from mare's feces and environment.

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Clostridium perfringens

G+ anaerobic bacteria affecting young foals, linked to ingesting colostrum with trypsin inhibitors. Types A and C are important.

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C. perfringens Type C

Causes severe, hemorrhagic diarrhea with endotoxemia and shock, high mortality, and poor response to treatment.

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Clostridioides difficile exotoxins

Causes fluid secretion and mucosal damage.

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Clostridial Diarrhea Prevention

Isolation, biosecurity, and C. perfringens toxoid for mares before birth.

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Salmonella

Causes inflammatory diarrhea.

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Rotavirus

Infection impacts the tips of villi leading to enterocyte destruction.

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Rotavirus Prevention

Isolation (10 days) and biosecurity focused on environment.

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Coronavirus

Enveloped RNA virus affecting foals, often with mild signs unless co-infection occurs.

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Lawsonia intracellularis

G- bacteria causing enteropathy in weanlings, leading to malabsorption.

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Signs of Lawsonia

Hypoalbuminemia (ventral edema) is the most consistent finding.

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Treating/Preventing Lawsonia

Oxytetracycline, isolation, and biosecurity.

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Diagnosing Diarrhea

Check for infectious vs. non-infectious signs, SIRS, and dehydration levels.

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Blood Work for Diarrhea

CBC and blood chemistry to look for signs of sepsis and electrolyte imbalances.

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Treatment of Diarrhea

Broad-spectrum antibiotics and anti-inflammatories are key.

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Fluid Therapy Goals

Restoration of circulating volume and electrolyte balance.

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Study Notes

Diarrhea in Foals

  • Diarrhea is a common issue in foals, with up to 80% experiencing at least one episode before 6 months of age.
  • Causes can range from self-limiting to life-threatening.
  • Diagnosing the specific cause of diarrhea can be challenging based solely on clinical signs.

Assessment of Diarrhea

  • It's important to confirm that the foal truly has diarrhea.
  • Diarrhea can indicate a severe gastrointestinal issue, such as a strangulating lesion.
  • A full colic evaluation is necessary for foals presenting with diarrhea, including:
    • Nasogastric tube
    • Abdominal ultrasound
    • Digital palpation

Types of Diarrhea

  • Diarrhea can be be a primary infectious or non-infectious issue
  • Diarrhea can be secondary to sepsis or Neonatal Asphyxia Syndrome (necrotizing enteritis).

Primary Causes of Diarrhea in Neonates

  • Non-infectious causes:
    • Foal heat diarrhea
    • Nutritional factors
  • Infectious causes:
    • Clostridium perfringens
    • Clostridioides difficile
    • Salmonella enterica
    • Rotavirus
    • Coronavirus
    • Enterococcus durans
    • Cryptosporidium parvum
    • Strongyloides westerii

Foal Heat Diarrhea

  • Typically occurs in the first 1-2 weeks of life, affecting up to 80% of foals.
  • Not related to the mare's estrus cycle.
  • Can affect orphaned foals or those on milk replacer without dam contact.
  • May involve the development of GI flora or small intestinal hypersecretion.
  • Usually mild and rarely requires treatment

Nutritional Diarrhea

  • Related to:
    • Overingestion of milk
    • Overfeeding orphaned or sick foals
    • Incorrect milk replacer mixing
  • Osmotic diarrhea arises from dietary mistakes overwhelming the small intestine's capacity and hindgut lactose fermentation.
  • Typically mild and addressed with diet adjustment.

Infectious Causes of Diarrhea

  • Often associated with more severe disease compared to non-infectious diarrhea.
  • 50% of foals with diarrhea develop bacteremia.
  • Mare's feces and the environment act as frequent sources of infectious agents.
  • E. coli is not considered a primary cause of diarrhea, but it can lead to sepsis and bacteremia.

Clostridium perfringens

  • This G+ anaerobic, spore-forming bacteria can cause illness in foals, even as young as 36 hours and under 10 days old.
  • It can also affect adult horses.
  • Often connected to ingesting colostrum that contains trypsin inhibitors.
  • It exists as a soil pathogen, present in the environment and dry lots resulting in annual outbreaks in endemic farms.
  • Types A and C are significant in horses.
  • C. perfringens type A:
    • Isolated from 90% of healthy 3-day-old foals.
    • Causes moderate severity disease with good treatment response.
    • Enterotoxin is accountable for severe disease.

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