equine pathology

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Questions and Answers

What condition is most commonly associated with Rhodococcus equi in foals?

  • Pyogranulomatous pneumonia (correct)
  • Chronic pleuropneumonia
  • Bacterial meningitis
  • Viral pneumonia

Which of the following factors increases the risk of infection by Rhodococcus equi in young foals?

  • Waning passive humoral immunity (correct)
  • Regular vaccination
  • Overcrowding in stables
  • Exposure to contaminated food

Which method is used to diagnose infections caused by Rhodococcus equi?

  • Viral culture and sensitivity
  • Physical examination alone
  • Bacterial culture and/or PCR amplification (correct)
  • Serum biochemical analysis

Which of the following statements about the infection spread of Rhodococcus equi is TRUE?

<p>Infection can occur through airborne contamination. (B)</p> Signup and view all the answers

What characterizes the lung lesions associated with Rhodococcus equi infection?

<p>Coalescing, semi-soft to firm white to yellow nodules (B)</p> Signup and view all the answers

What is often a result of failure of passive transfer in foals infected with Rhodococcus equi?

<p>Higher risk of bacterial infections (C)</p> Signup and view all the answers

Which type of inflammatory response is primarily observed in the lungs of foals infected with Rhodococcus equi?

<p>Pyogranulomatous pneumonia (B)</p> Signup and view all the answers

What is a significant feature of the lesions found in the mesenteric lymph nodes during Rhodococcus equi infection?

<p>Diffuse enlargement with necrosis (B)</p> Signup and view all the answers

What is a key clinical sign associated with Clostridium piliforme infection?

<p>Diarrhoea (B)</p> Signup and view all the answers

Which organism is commonly linked to septicemia as a pathogen that can cause Tyzzers disease?

<p>E. coli (C)</p> Signup and view all the answers

What type of lesions are associated with Clostridium piliforme?

<p>Miliary grey foci (B)</p> Signup and view all the answers

What is a potential pathogenesis mechanism for Clostridium piliforme infection?

<p>Transmission via fecal matter (C)</p> Signup and view all the answers

Which of the following clinical signs might indicate liver involvement in Tyzzers disease?

<p>Haemorrhage (C)</p> Signup and view all the answers

Which of the following features is typical for the diagnosis of Tyzzers disease?

<p>Typical gross findings in the liver (B)</p> Signup and view all the answers

What does the pathogenesis of Clostridium piliforme primarily involve?

<p>Bacterial invasion of intestinal mucosa (C)</p> Signup and view all the answers

Which of the following clinical signs is not typically associated with Tyzzers disease?

<p>Excessive drooling (C)</p> Signup and view all the answers

What type of lesions is associated with Strongylus vulgaris infection?

<p>Multifocal proliferative necrosis of the large colon (C)</p> Signup and view all the answers

What clinical signs may indicate a Strongylus vulgaris infection?

<p>Severe abdominal pain (colic signs) (B)</p> Signup and view all the answers

What is the primary vessel affected by the larvae of Strongylus vulgaris?

<p>Cranial mesenteric artery (B)</p> Signup and view all the answers

During which months are peak pasture egg counts for Strongylus vulgaris typically observed?

<p>July to September (C)</p> Signup and view all the answers

How do horses typically become infected with Strongylus vulgaris?

<p>By ingestion of L3 larvae from contaminated food (B)</p> Signup and view all the answers

What type of arteritis is caused by Strongylus vulgaris?

<p>Chronic proliferative arteritis with mural thrombosis (B)</p> Signup and view all the answers

What is a common aspect of the pathogenesis associated with Strongylus vulgaris?

<p>Random walk within blood vessels (B)</p> Signup and view all the answers

What is a distinguishing characteristic of the larvae migration of Strongylus vulgaris?

<p>They follow the curvature of blood vessels (D)</p> Signup and view all the answers

What type of lesions are characteristic of Actinobacillus equuli infection?

<p>Multifocal small white miliary lesions (D)</p> Signup and view all the answers

Which clinical sign is NOT associated with Actinobacillus equuli infection?

<p>Fever (A)</p> Signup and view all the answers

What is the primary method for diagnosing Actinobacillus equuli in live foals?

<p>Isolation of bacteria by culture from blood (B)</p> Signup and view all the answers

Which of the following is the most common cause of emboli in Actinobacillus equuli infections?

<p>Septic emboli from bacteremia (D)</p> Signup and view all the answers

How can Actinobacillus equuli be transmitted in utero?

<p>From the mother during parturition (B)</p> Signup and view all the answers

What can lead to successive abortion in mares infected with Actinobacillus equuli?

<p>Endogenous non-systematic bacterial persistence (B)</p> Signup and view all the answers

In which organ is suppurative nephritis most commonly diagnosed in foals due to Actinobacillus equuli?

<p>Kidney (A)</p> Signup and view all the answers

What occurs in adult horses that have Actinobacillus equuli infection?

<p>They become carriers with colonization of genitourinary tracts. (A)</p> Signup and view all the answers

What is the primary cause of multifocal necrosis in the liver?

<p>Bacterial colonization of hepatic parenchyma (C)</p> Signup and view all the answers

What type of hepatitis is characterized by pyogranulomatous inflammation?

<p>Pyogranulomatous hepatitis (B)</p> Signup and view all the answers

Which lesion is associated with enterocolitis in foals?

<p>Crypt abscesses within enterocytes (C)</p> Signup and view all the answers

Which organ is primarily affected by the spread of bacteria via the portal circulation?

<p>Liver (C)</p> Signup and view all the answers

What clinical sign might indicate necrotizing enterocolitis in a foal?

<p>Diarrhea with blood (B)</p> Signup and view all the answers

Which type of necrosis is associated with myocardial tissue during infection?

<p>Foci of myocardial necrosis (B)</p> Signup and view all the answers

What is a significant pathological finding in the intestine due to bacterial infection?

<p>Bacterial collections within enterocytes (C)</p> Signup and view all the answers

What type of histopathological evidence is characteristic of pyogranulomatous hepatitis?

<p>Granulomas filled with neutrophils (C)</p> Signup and view all the answers

What causes multiple microabscesses in small capillaries and glomeruli?

<p>Septicaemia (C)</p> Signup and view all the answers

Which of the following conditions can predispose animals to septicaemia?

<p>Malnutrition of the dam (C)</p> Signup and view all the answers

What is a key clinical sign of grass sickness or equine dysautonomia?

<p>Cholic (A)</p> Signup and view all the answers

In histological examination of grass sickness, what is typically observed?

<p>Neuronal degradation of intestinal and extra intestinal ganglia (D)</p> Signup and view all the answers

The reddened neurons seen in grass sickness indicate what?

<p>Reactive changes due to degeneration (C)</p> Signup and view all the answers

What role does unsanitary birthing conditions play in animal health?

<p>May lead to failure of passive transfer (B)</p> Signup and view all the answers

Which organ, besides the kidneys, commonly shows microabscesses in cases of septicaemia?

<p>Liver (C)</p> Signup and view all the answers

What pathophysiological mechanism primarily results from clostridium botulinum type C?

<p>Destruction of neural pathways (C)</p> Signup and view all the answers

Flashcards

Tyzzer's disease

A bacterial disease in horses primarily affecting the liver. It is often fatal to foals and can cause liver enlargement with multiple small grey spots (miliary foci).

Miliary foci

Small, pinpoint-sized spots that are grey in color, often found on the liver in cases of Tyzzer's disease.

Necrotizing enterocolitis

Inflammation of the intestines with necrosis (tissue death).

Icterus

Yellowing of the skin and tissues due to bilirubin accumulation

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Meningitis

Inflammation of the brain and its membranes, often a sign of infectious disease.

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Sleepy Foal Disease

An infectious disease caused by the bacteria Actinobacillus equuli, often characterized by lethargy and neurological signs in foals.

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Equine Herpes Virus 1 (EHV-1)

A highly contagious viral disease in horses that can cause a variety of symptoms including fever, respiratory distress, neurological signs, and abortion.

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Salmonella sp. and E. coli

Bacteria present in the intestines of horses that can cause infections, including those related to Tyzzer's disease.

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Multifocal Hepatic Necrosis

Necrosis in multiple areas of the liver, often with surrounding hemorrhage and inflammatory cells.

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Pyogranulomatous Hepatitis

Inflammation of the liver characterized by pus and small, granular clumps of tissue.

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Enterocolitis

Inflammation of the intestine, often with tissue death, commonly seen in foals and other animal species.

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Crypt Abscesses

Small pockets of pus within the intestinal lining.

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Myocardial Necrosis

Areas of dead tissue in the heart muscle.

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Bacterial Dissemination via Blood

Bacteria spreading through the bloodstream to various organs.

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Hepatic Colonization

Bacteria colonizing and multiplying within the liver tissue.

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Bundles of Bacteria within Enterocytes

Groups of bacteria found within the cells lining the intestines.

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Strongyle Arteritis

A disease of horses caused by parasitic strongyles, specifically Strongylus vulgaris, that affects the cranial mesenteric artery. It involves larval migration in the artery and causes inflammation, thrombosis, and potential bowel perfusion disruption.

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Cholic Signs

A symptom of Strongyle Arteritis. It's characterized by sudden abdominal pain, colic, and potential for bowel ischemia. Occurs due to interruption of blood flow caused by thrombosis or vascular damage.

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Strongylus vulgaris

A specific type of strongyle, also known as the large strongyle, causes Strongyle Arteritis. The larval form of this worm migrates through the blood vessels and can cause damage to the cranial mesenteric artery.

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Cranial Mesenteric Artery

The cranial mesenteric artery is a key artery in the horse's digestive system. Strongyle Arteritis primarily affects this artery due to the larva’s tendency to migrate through it.

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Transmural Arteritis

A chronic inflammatory process in the cranial mesenteric artery, characterized by thickening of the vessel wall due to inflammation and fibrosis (scarring). This leads to narrowing of the artery and potential blockage.

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Bowel Perfusion Disruption

A serious consequence of inflammation and thrombosis in the cranial mesenteric artery. It can disrupt blood supply to the intestines, possibly leading to diarrhea, colic, and even death.

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L3 larvae

The L3 larval stage of strongyles is the infectious stage. These larvae are ingested by horses and mature in the intestines. Certain strongyles, like Strongylus vulgaris, migrate throughout the circulatory system.

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Ingestion of Contaminated Food

The primary route of Strongylus vulgaris infection in horses. Ingesting contaminated food or water containing L3 larvae allows the parasites to enter the horses and initiate their migration in the body.

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Suppurative Nephritis

Inflammation of the kidneys, often caused by bacteria entering the bloodstream and forming small abscesses within the kidney tissue.

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Miliary Lesions in the Kidney

Small, white spots on the surface of the kidneys, indicative of inflammation and bacterial colonies.

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Septic Emboli

Tiny blood clots that travel through the bloodstream and lodge in various organs, often carrying bacteria that cause infection.

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Endogenous Bacteria

Bacteria that normally resides in the body without causing illness, but can become harmful under certain conditions.

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Bacteremia

A condition where bacteria spread throughout the bloodstream, potentially leading to infections in various organs.

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Pathogenesis

The process by which a disease develops and progresses.

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Bacteremia

The presence of bacteria in the blood, indicating a systemic infection.

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Bacterial Dissemination

The spread of bacteria from one location within the body to other parts, often via the bloodstream.

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Rhodococcus equi Pneumonia

A bacterial disease in horses caused by Rhodococcus equi, often affecting young foals and characterized by lung abscesses and other clinical signs.

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Habitat of Rhodococcus equi

The bacteria Rhodococcus equi naturally lives in the soil and the digestive system of herbivores, making it a common environmental exposure.

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Susceptibility to Rhodococcus equi in Foals

Young foals are more susceptible to Rhodococcus equi infection due to their developing immune systems. They often haven't received enough passive immunity from their mother's colostrum.

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Transmission of Rhodococcus equi

The bacteria Rhodococcus equi spreads through the air when contaminated dust is inhaled, affecting the respiratory system.

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Pyogranulomatous Pneumonia

Inflammation of the lungs with the formation of pus-filled cavities (abscesses). This is the most common finding in Rhodococcus equi infection.

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Mesenteric Lymph Node Enlargement

Enlarged and inflamed lymph nodes in the abdominal cavity, often a sign of Rhodococcus equi infection.

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Multifocal Ulcerative Colitis

Inflammation of the intestines with multiple ulcers, often seen in cases of Rhodococcus equi infection.

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Pyogranulomatous Necrosis

The presence of pus-filled nodules (clumps of tissue) centrally surrounded by areas of dead tissue. This is a characteristic finding in Rhodococcus equi infection.

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Grass sickness

A condition in horses caused by the bacterium Clostridium botulinum, resulting in paralysis and difficulty swallowing.

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Cholic

A serious complication of Strongyle Arteritis, with symptoms like colic and potentially bowel ischemia.

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Study Notes

Clostridium Piliforme (Tyzzer's Disease)

  • Lesions: Diffusely enlarged, with miliary grey foci. Multiple, small lesions with surrounding normal tissue. Multifocal or coalescing irregular areas of necrotizing and pyogranulomatous hepatitis, potentially with hemorrhage.
  • Clinical Signs: Diarrhoea, joint lesions, pneumonia, and meningitis.
  • Pathogenesis/Causes: Often associated with equine herpesvirus type 1, Salmonella spp., or E.coli septicaemia, Actinobacillus equuli (sleepy foal disease), or Listeria monocytogenes. Transmission is typically via ingested fecal matter. Bacteria enter the intestinal tract and reach the liver via portal circulation. Multifocal hepatic necrosis can result.
  • Diagnosis: Gross findings include icterus (jaundice), liver enlargement. Multiple pinpoint to miliary grey foci within the liver. Necrotizing enterocolitis and oedema/congestion of the intestine. Heart may show white linear bands. Lymph nodes are often haemorrhagic and oedematous. Microscopic findings include multifocal to coalescing irregular areas of hepatic necrosis which are often surrounded by inflammation, macrophages, and neutrophils (pyogranulomatous hepatitis). Enterocolitis, sometimes necrotizing. Possible presence of bacteria within enterocytes and crypt abscesses. Heart tissue may show foci of myocardial necrosis.

Strongylus Vulgaris

  • Lesions: Segmental (localized) and extensive transmural necrosis of the large colon; chronic, severe, focally extensive proliferative and necrotizing transmural arteritis with mural thrombosis, with numerous intralesional larval strongyles.
  • Clinical Signs: Cholic signs, but asymptomatic unless thrombosis or vascular damage compromise bowel perfusion.
  • Pathogenesis/Causes: Horses ingest L3 larvae. Peak pasture egg counts are typically from July to September. Larvae migrate to the cranial mesenteric artery and its branches. Random movement of these larvae causes damage along with their presence following vessel curvature. Not all larvae enter the aorta due to the perpendicular connection with the main artery. This can lead to cholic signs.
  • Diagnosis: Cranial mesentery artery, chronic, multifocal proliferative and necrotizing transmural arteritis with mural thrombosis containing numerous strongyle larvae.

Coccobacilli

  • Lesions: Multifocal to coalescing white to yellow semi-soft to firm nodules in the lung. Diffuse enlargement of mesenteric lymph nodes. Pyogranulomatous pneumonia, multifocal ulcerative colitis, pyogranulomatous and necrotizing central core, multifocal to coalescing pyogranulomatous, lympho-plasmacytic pneumonia with intrahistiocytic coccobacilli.
  • Clinical Signs: Lethargy, fever, cough, increased respiration.
  • Pathogenesis/Causes: Rhodococcus equi is the common cause. Normally inhabits soil and the gastrointestinal tracts of herbivores.
  • Diagnosis: Radiographic or ultrasonographic evidence of lung abscesses. Bacterial culture and/or PCR in combination with cytological examination of transtracheal aspirates.

Actinobacillus Equuli

  • Lesions: Multifocal small white miliary lesions in the kidney cortex. Blue areas of multi-focal lesions of inflammatory, degenerate neutrophils. Multifocal embolism, suppurative necrotizing nephritis with large colonies of coccobacilli, tubular degeneration and necrosis.
  • Clinical Signs: Unwillingness to move, diarrhoea, hypernea, dehydration, conjunctival inflammation.
  • Pathogenesis/Causes: Most common cause of suppurative nephritis in foals. Can enter the body pre/postnatally (e.g., from the umbilicus or during birth). Bacilli may persist, causing successive abortion in mares. Bacteremia causes septic emboli, lodging in small capillaries, glomeruli, or other organs. Inflammation or necrosis may obstruct glomeruli. Can be a predisposing factor to septicaemia and death in foals.
  • Diagnosis: Isolation of bacteria via culture. Blood cultures for live foals, post-mortem kidney and lung biopsy for dead foals, primary organ focus for adult horses

Grass Sickness/Equine Dysautonomia

  • Lesions: Cranial cervical ganglion, check eosinophilic colour, reddened neurones showing neurological damage, degeneration of neuronal clusters, plexa affected.
  • Clinical Signs: Weight loss, cholic (abdominal pain), tachycardia (fast heart rate), sweating, tucked abdomen.
  • Pathogensis/Causes: Caused by Clostridium botulinum type C neurotoxin. Affecting nerves leading to issues with food passage through the intestines. The acute clinical presentation includes colic, tympany, drooling, which rapidly progresses toward a nearly always-fatal outcome within 7 days.
  • Diagnosis: Histological examination reveals neuronal degradation in intestinal and extra-intestinal ganglia. Cytological examination of cranial cervical ganglion is a relevant post-mortem diagnostic method.

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