Diabetes Medications: Alpha-Glucosidase Inhibitors

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Questions and Answers

A patient with type II diabetes is also diagnosed with cirrhosis. Which alpha-glucosidase inhibitor should be avoided for this patient?

  • Repaglinide
  • Nateglinide
  • Acarbose (correct)
  • Miglitol

Which of the following medications is most likely to be prescribed in conjunction with metformin to enhance glycemic control?

  • Repaglinide (correct)
  • Miglitol
  • Rosiglitazone maleate
  • Acarbose

Glyburide is classified under which category of oral antidiabetic agents?

  • Thiazolidinedione
  • Biguanide
  • Alpha-glucosidase inhibitor
  • Sulfonylurea (correct)

A patient with type 2 diabetes is prescribed rosiglitazone maleate. What potential severe adverse effect should the patient be closely monitored for?

<p>Heart failure (D)</p> Signup and view all the answers

Metformin, a commonly prescribed medication for type 2 diabetes, belongs to which class of drugs?

<p>Biguanides (A)</p> Signup and view all the answers

Acarbose is most effective when combined with what type of medication for optimal blood glucose control?

<p>A sulfonylurea (D)</p> Signup and view all the answers

Which class of oral hypoglycemic agents primarily functions by stimulating the pancreatic secretion of insulin?

<p>Meglitinides (C)</p> Signup and view all the answers

Why is it important to discontinue metformin 48 hours before and after procedures involving contrast dye?

<p>To minimize the risk of lactic acidosis (A)</p> Signup and view all the answers

An 82-year-old patient with type 2 diabetes is prescribed an oral antidiabetic medication. Considering the patient's age, which medication should be used with caution due to the risk of lactic acidosis?

<p>Metformin (A)</p> Signup and view all the answers

Which patient population is at higher risk of adverse reactions when taking Metformin?

<p>Patients with alcohol use disorder (C)</p> Signup and view all the answers

A patient needs a rapid-acting insulin bolus before a meal but only has access to Humulin R and insulin lispro. Which insulin should be administered and when?

<p>Administer insulin lispro 15 minutes before the meal. (A)</p> Signup and view all the answers

A patient newly diagnosed with diabetes requires both a rapid-acting insulin for mealtime coverage and a basal insulin to cover insulin needs between meals and overnight. Which combination is most appropriate based on the available medications?

<p>Insulin glargine and Insulin lispro. (A)</p> Signup and view all the answers

A patient is prescribed Isophane (NPH) insulin. What is the primary reason for the inclusion of zinc in this type of insulin formulation?

<p>To slow down insulin absorption, prolonging its effect. (C)</p> Signup and view all the answers

A doctor is deciding between different rapid-acting insulin for a patient who needs precise control over post-meal glucose excursions. Which rapid-acting insulin analog would be the MOST appropriate if the doctor wants the one with the shortest onset of action?

<p>Insulin glylisin. (A)</p> Signup and view all the answers

A patient taking insulin detemir reports inconsistent blood sugar control despite consistent dosing. What should the healthcare provider consider FIRST regarding this patient's insulin regimen?

<p>Patient may be mixing detemir with other insulins, which is not recommended. (D)</p> Signup and view all the answers

Flashcards

Alpha-Glucosidase Inhibitors

Inhibits enzymes that break down carbohydrates, lowering post-meal blood glucose.

Acarbose (Precose)

An alpha-glucosidase inhibitor that helps to improve glycosylated hemoglobin levels.

Thiazolidinediones (Glitazones)

A class of drugs that enhances insulin sensitivity in peripheral tissues.

Meglitinides

Stimulate the pancreas to release insulin, primarily after meals.

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Repaglinide

A meglitinide medication often paired with metformin to manage blood sugar levels.

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Sulfonylureas

Oral medication for type 2 diabetes that stimulates insulin release.

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Glyburide

Prototype sulfonylurea drug.

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Metformin

Oral medication, reduces liver glucose production, used for type 2 diabetes.

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Lactic acidosis

A risk of Metformin, especially with alcohol use.

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Metformin Discontinuation

Stop this medication 48 hours before/after contrast dye tests.

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Humulin

Human insulin; one type of "Regular" insulin.

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Lispro

Rapid-acting insulin analog, identical to human insulin.

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Glylisin

Rapid-acting insulin with the shortest onset of action (5-10 min).

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Isophane (NPH)

Intermediate-acting insulin that contains zinc to slow absorption.

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Detemir

Long-acting insulin that cannot be mixed with other insulin types.

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Study Notes

Alpha-Glucosidase Inhibitors

  • Treats Type II diabetes
  • Includes Acarbose (Precose), which improves glycosylated hemoglobin levels
  • Also includes Miglitol
  • Should not be used on people that have cirrhosis, chronic intestinal disease and chronic ulceration
  • Works well with a sulfonylurea to control blood glucose levels

Thiazolidinediones (glitazones)

  • Includes Rosiglitazone maleate; rarely prescribed due to risk of heart failure

Meglitinides

  • Stimulates pancreatic secretion of insulin
  • Includes Repaglinide, which is used with metformin
  • Also includes Nateglinide

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