Diabetes Insipidus (DI) Types and Causes
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Questions and Answers

What is the origin of Oxytocin?

  • Created in the kidney
  • Synthesized in the posterior pituitary
  • Produced in Paraventricular nuclei in the hypothalamus (correct)
  • Derived from the adrenal glands

Which defect causes Nephrogenic Diabetes Insipidus?

  • Lesion of the hypothalamo-hypophyseal tract above the median eminence
  • Autosomal mutation of V2 receptors gene in the kidney (correct)
  • X-linked mutation of aquaporin2 gene
  • Lesion in the supraoptic nucleus

Why do patients with Diabetes Insipidus experience polyuria?

  • Increased blood glucose levels
  • Excessive water loss with no increase in other constituents (correct)
  • Decreased water intake
  • Excessive sodium loss in urine

What mechanism of action does Oxytocin have?

<p>Binds to receptors coupled to a G Protein enzyme and induces an increase in cytoplasmic Ca2+ for muscle contraction (C)</p> Signup and view all the answers

What causes Central Diabetes Insipidus?

<p>Lesion in the supraoptic nucleus (A)</p> Signup and view all the answers

Why do patients with Diabetes Insipidus develop polydipsia?

<p>To prevent dehydration due to excessive polyuria (A)</p> Signup and view all the answers

Which protein carries 2/3 of T4 and 1/2 of T3 in the blood?

<p>Thyroxine binding globulin (TBG) (D)</p> Signup and view all the answers

Why is T3 more active than T4?

<p>It has a higher affinity to thyroid receptors (C)</p> Signup and view all the answers

Which type of thyroid receptor does T3 specifically bind to?

<p>α 1, α 2, and β 2 (C)</p> Signup and view all the answers

Where are extranuclear thyroid receptors found?

<p>Mitochondria (A)</p> Signup and view all the answers

Which of the following is NOT a non-genomic action mediated by extranuclear receptors?

<p>DNA replication (A)</p> Signup and view all the answers

What is the primary physiological effect of Thyroid Hormones on metabolism?

<p>Stimulation of metabolic rate (D)</p> Signup and view all the answers

What effect do excessive thyroid hormones have on mitochondria?

<p>Mitochondrial swelling and increased uncoupling of oxidative phosphorylation (C)</p> Signup and view all the answers

How do thyroid hormones affect Na/K ATPase enzyme activity in cell membranes?

<p>Increased enzyme activity (B)</p> Signup and view all the answers

What effect do thyroid hormones have on protein metabolism?

<p>Increased protein synthesis (B)</p> Signup and view all the answers

How do thyroid hormones affect fat metabolism?

<p>Increase lipolysis and free fatty acid oxidation (C)</p> Signup and view all the answers

Which process is NOT affected by thyroid hormones?

<p>Cholesterol synthesis (B)</p> Signup and view all the answers

What is the consequence of increased activity of Na/K ATPase enzyme due to thyroid hormones?

<p>Increased energy consumption (B)</p> Signup and view all the answers

What stimulates the osteoblasts production of IL-6 and RANKL?

<p>PTH (C)</p> Signup and view all the answers

Which cells have no receptors for PTH?

<p>Osteoclasts (C)</p> Signup and view all the answers

What does PTH do to phosphate reabsorption in the renal proximal convoluted tubules?

<p>Decreases it (A)</p> Signup and view all the answers

What is the role of 1,25(OH)2D3 (dihydroxycholecalciferol) in the kidneys?

<p>Activates enzyme production (C)</p> Signup and view all the answers

What effect does PTH and 1,25(OH)2D3 have on calcium reabsorption in the distal part of renal tubules?

<p>Increases it (B)</p> Signup and view all the answers

What effect do PTH and 1,25(OH)2D3 have on calcium and phosphate absorption by the intestine?

<p>Increase both (A)</p> Signup and view all the answers

How is calcium primarily absorbed in the upper small intestine?

<p>Passive diffusion (D)</p> Signup and view all the answers

Which factor affects the solubility of calcium salts in the gastrointestinal tract?

<p>Acidic food products (D)</p> Signup and view all the answers

What is the role of vitamin D3 in calcium absorption?

<p>Stimulates calcium absorption (D)</p> Signup and view all the answers

Which compound plays a crucial role in cell phosphorylation and dephosphorylation reactions?

<p>ATP (A)</p> Signup and view all the answers

What happens when the concentration of cations and anions in a solution exceeds the solubility product?

<p>Precipitation of the salt occurs (A)</p> Signup and view all the answers

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