Diabetes Insipidus: Causes, Types and Manifestations
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Questions and Answers

A patient presents with polyuria, polydipsia, and a recent head trauma. Which type of diabetes insipidus (DI) is MOST likely?

  • Gestational DI
  • Nephrogenic DI
  • Central DI (correct)
  • Primary DI

Which assessment finding would differentiate primary (psychogenic) diabetes insipidus (DI) from central or nephrogenic DI?

  • Hypernatremia
  • Tachycardia
  • Hypervolemia (correct)
  • Hypotension

A patient with diabetes insipidus (DI) is undergoing a water restriction test. Which finding would suggest central DI rather than nephrogenic DI?

  • Continued excretion of large volumes of dilute urine
  • Development of severe hypernatremia
  • Decreased plasma osmolality during water restriction
  • Increased urine osmolality after ADH administration (correct)

What is the primary therapeutic goal in managing a patient with diabetes insipidus (DI)?

<p>Maintenance of fluid and electrolyte balance (D)</p> Signup and view all the answers

A patient with nephrogenic diabetes insipidus (DI) is prescribed hydrochlorothiazide. What is the rationale for this medication in this context?

<p>To promote sodium retention and reduce urine volume (A)</p> Signup and view all the answers

Which electrolyte imbalance is MOST likely to contribute to nephrogenic diabetes insipidus (DI)?

<p>Hypokalemia (C)</p> Signup and view all the answers

A patient with central diabetes insipidus (DI) is prescribed desmopressin (DDAVP). Which statement indicates effective teaching about this medication?

<p>&quot;I should limit my fluid intake to prevent water intoxication.&quot; (C)</p> Signup and view all the answers

A patient with diabetes insipidus (DI) develops a sudden change in mental status and severe dehydration. Which intervention is the PRIORITY?

<p>Administering isotonic intravenous fluids (C)</p> Signup and view all the answers

What is the PRIMARY underlying mechanism leading to polyuria in diabetes insipidus (DI)?

<p>Impaired water reabsorption in the renal collecting ducts (B)</p> Signup and view all the answers

A nurse is caring for a patient with diabetes insipidus (DI). Which assessment finding requires IMMEDIATE intervention?

<p>Serum sodium level of 155 mEq/L (C)</p> Signup and view all the answers

A patient with central diabetes insipidus (DI) is being treated with Desmopressin acetate (DDAVP). Which finding suggests the medication is not having the intended therapeutic effect?

<p>A urine specific gravity of 1.001 (D)</p> Signup and view all the answers

What treatment should a nurse expect to see prescribed for a patient with nephrogenic diabetes insipidus (DI)?

<p>Thiazide diuretics (D)</p> Signup and view all the answers

In a patient with central diabetes insipidus (DI), how will the administration of Aqueous vasopressin (Pitressin) affect the patient during a water deprivation test?

<p>Increase in urine osmolality (D)</p> Signup and view all the answers

A patient with central diabetes insipidus is receiving DDAVP. The nurse should monitor for which of the following adverse effects that would indicate a need to adjust the dosage?

<p>Edema (B)</p> Signup and view all the answers

A patient with nephrogenic diabetes insipidus is prescribed a low-sodium diet and thiazide diuretic. What is the rationale for this combination of therapies?

<p>To promote sodium excretion and reduce urine volume (B)</p> Signup and view all the answers

Which of the following is the priority nursing assessment for a patient newly diagnosed with diabetes insipidus?

<p>Monitoring fluid balance (B)</p> Signup and view all the answers

A patient with diabetes insipidus is ordered to receive vasopressin. What is the most important nursing intervention related to this medication?

<p>Assess for chest pain and shortness of breath (B)</p> Signup and view all the answers

A patient with diabetes insipidus is being discharged home on desmopressin (DDAVP). Which of the following instructions is most important for the nurse to emphasize?

<p>Weigh themselves daily and report any significant weight gain (B)</p> Signup and view all the answers

A patient with nephrogenic diabetes insipidus is prescribed indomethacin (Indocin) in addition to a low-sodium diet and thiazide diuretic. What is the purpose of adding indomethacin to the treatment regimen?

<p>To decrease prostaglandin synthesis and increase renal responsiveness to ADH (D)</p> Signup and view all the answers

A nurse is caring for a patient with diabetes insipidus (DI) who is receiving fluid replacement therapy. Which assessment finding is the best indicator that the fluid resuscitation is effective?

<p>Improved skin turgor (A)</p> Signup and view all the answers

Flashcards

Diabetes Insipidus (DI)

Deficiency in ADH production/secretion or decreased renal response to ADH.

Central DI (Neurogenic)

Most common type; caused by issues with the brain's ADH production.

Nephrogenic DI

Type of DI caused by kidney's decreased response to ADH; may be linked to electrolyte imbalances.

Primary DI (Psychogenic)

Rare type; caused by excessive fluid intake.

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Polyuria

Excessive excretion of urine.

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Polydipsia

Excessive thirst.

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Fluid Volume Deficit Symptoms

Weight loss, poor skin turgor, hypotension, tachycardia, constipation & shock

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CNS Manifestations of DI

Irritability, mental dullness, or even coma.

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Water Restriction Test

Used to confirm central DI by monitoring urine output and ADH levels after fluid restriction.

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Therapeutic goal for DI

Adequate hydration, patient education and fluid/electrolyte balance

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Central Diabetes Insipidus

DI caused by a deficiency in the secretion of ADH from the posterior pituitary gland.

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Fluid Replacement (in DI)

Replacing fluids lost due to excessive urination.

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Hormone Replacement (in DI)

Replacing deficient hormones, often ADH.

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I&O Monitoring in DI

Regularly monitoring fluid intake and output.

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Desmopressin (DDAVP)

Hormone replacement of choice for central DI.

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Fluid Volume Excess in DI Treatment

Increased fluid volume with low urine specific gravity.

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Aqueous Vasopressin (Pitressin)

Medication used for ADH replacement.

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Low-Sodium Diet (for Nephrogenic DI)

Diet low in sodium, helps manage nephrogenic DI.

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Thiazide Diuretics (for Nephrogenic DI)

Type of diuretic used in nephrogenic DI to paradoxically reduce urine output.

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Pitressin Effect on Urine Osmolality

In central DI, Pitressin will cause increase in urine osmolality (concentration).

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Study Notes

  • Diabetes Insipidus (DI) is associated with a deficiency of production or secretion of antidiuretic hormone (ADH), or a decreased renal response to ADH.
  • DI can either be transient or a chronic, lifelong condition, depending on its cause.

Types of DI

  • Central DI, also known as neurogenic, is the most common form.
  • Nephrogenic DI, which may lead to hypokalemia and hypercalcemia.
  • Primary DI, also known as psychogenic, is less common.

Clinical Manifestations

  • Excretion of large quantities of urine, referred to as polyuria.
  • Polydipsia, characterized by excessive thirst.

Fluid Volume Deficit (Manifestations)

  • Weight loss
  • Poor tissue turgor
  • Hypotension
  • Tachycardia
  • Constipation
  • Shock

Central Nervous System (CNS) Manifestations

  • Irritability.
  • Mental dullness.
  • Coma.

Diagnostic Studies

  • Identification of the cause is the initial step.
  • It is important to collect Patient History.
  • A Physical Examination is required.
  • Primary or psychogenic DI is associated with overhydration and hypervolemia.
  • Dehydration and hypovolemia are seen in other forms of DI.
  • Water restriction test is done to confirm the diagnosis of central DI.

Nursing and Collaborative Management

  • Early detection is essential.
  • Maintenance of adequate hydration is important.
  • Patient teaching for long-term management is required.
  • The therapeutic goal is maintenance of fluid and electrolyte balance.

Central DI Management

  • Fluid replacement.
  • Hormone replacement.
  • Fluid Volume Status Assessment is required.
  • Accurate records of intake and output are needed.
  • Monitor urine specific gravity.
  • Perform daily weight checks.
  • Desmopressin acetate (DDAVP) is the hormone replacement of choice.
  • Notify the healthcare provider immediately if the patient has increased fluid volume with low specific gravity.

Other Drugs for ADH Replacement include

  • Aqueous vasopressin (Pitressin).
  • Vasopressin tannate.
  • Lysine vasopressin (Diapid).

Treatment of Nephrogenic DI

  • Dietary measures such as a low-sodium diet and thiazide diuretics are recommended.
  • If these are ineffective, indomethacin (Indocin) may be prescribed.

Student Response Questions

  • For a patient with DI treated with nasal Desmopressin acetate (DDAVP), the nurse recognizes inadequate drug effect if the urine specific gravity is 1.001.
  • When attending to a patient with nephrogenic DI, the nurse would expect treatment with thiazide diuretics.
  • In a patient with central DI, administration of Aqueous vasopressin (Pitressin) during a water deprivation test will result in a decrease in urine output and an increase in urine osmolality.

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Description

Diabetes Insipidus (DI) is related to deficiency of antidiuretic hormone (ADH). DI can either be transient or a chronic condition, depending on its cause. Common symptoms include excretion of large quantities of urine and excessive thirst.

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