Diabetes and Pregnancy

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Questions and Answers

What is the initial treatment for a symptomatic neonate with hypoglycemia?

  • Give crystalline glucagon IM or SC
  • IV bolus of 200mg/kg of 10% glucose (correct)
  • Administer hydrocortisone 5mg/kg/day IV or IM
  • Start IV Dextrose 10% at 60ml/kg/day

What is the maximum dose of glucagon for neonates?

  • 0.3 mg/kg/dose
  • 1.5 mg/kg/dose
  • 2 mg/kg/dose
  • 1 mg/dose (correct)

What is the goal of initial IV infusion rate in hypoglycemic neonates?

  • 4.2 mg/kg/min glucose (correct)
  • 8 mg/kg/min glucose
  • 6 mg/kg/min glucose
  • 10 mg/kg/min glucose

What is the next step if the initial IV infusion rate is inadequate?

<p>Increase the infusion rate to 10-12 mg/kg/min (C)</p> Signup and view all the answers

What is the contraindication for treatment of hypoglycemia?

<p>Hypertonic glucose (B)</p> Signup and view all the answers

What is the recommended frequency of blood glucose level measurement?

<p>Hourly, then every 4-6 hours when normal (D)</p> Signup and view all the answers

What percentage of women are noted to have gestational diabetes during pregnancy?

<p>5% (B)</p> Signup and view all the answers

What is the primary reason for poor pregnancy outcomes in diabetic mothers?

<p>Inadequate glycemic control before and during pregnancy (C)</p> Signup and view all the answers

What is the average daily glucose level required for women with type 1 diabetes during pregnancy to deliver infants with normal birthweights and anthropomorphic features?

<p>&lt; 95 mg/dL (B)</p> Signup and view all the answers

What is the recommended HbA1c level for pregestational diabetes to achieve the best outcomes for the mother and the baby?

<p>HbA1c &lt; 6.5% (B)</p> Signup and view all the answers

What is the primary goal of treating gestational diabetes?

<p>Decreasing the rate of serious perinatal outcomes (B)</p> Signup and view all the answers

What is the primary cause of fetal mortality rate in diabetic mothers, especially after 32 weeks?

<p>Poorly controlled maternal diabetes (A)</p> Signup and view all the answers

What is the definition of hypoglycemia in infants?

<p>Serum glucose &lt; 2.6 mmol/L (A)</p> Signup and view all the answers

What is the percentage of infants born to diabetic mothers who are large for gestational age?

<p>36-45% (B)</p> Signup and view all the answers

What is the recommended course of action for asymptomatic infants?

<p>Undertake blood glucose determination within 1-2 hours of age (C)</p> Signup and view all the answers

What is the primary mechanism by which poorly controlled maternal diabetes leads to fetal hyperglycemia?

<p>Maternal hyperglycemia (C)</p> Signup and view all the answers

What is the consequence of fetal hyperglycemia on the fetal pancreas?

<p>Hyperplasia and hypertrophy of β cells (A)</p> Signup and view all the answers

What is the recommended treatment for infants with a glucose level between 1.2-2.5 mmol/L on the first testing?

<p>Rub 0.5 ml/kg of 40% dextrose gel into buccal mucosa and feed the baby (C)</p> Signup and view all the answers

What is the recommended course of action for infants with glucose levels below 1.2 mmol/L at any stage?

<p>Admit the infant to the NICU for close observation and treatment (C)</p> Signup and view all the answers

What is the risk of congenital malformations in gestational diabetes compared to the general population?

<p>Slightly higher (A)</p> Signup and view all the answers

What is the alternative treatment to insulin therapy for gestational diabetes?

<p>Glyburide (D)</p> Signup and view all the answers

What is the benefit of treating gestational diabetes with glyburide?

<p>Reduced risk of macrosomia and neonatal hypoglycemia (A)</p> Signup and view all the answers

What is the primary function of fetal hyperinsulinemia in the last trimester?

<p>Increased fat and protein synthesis (B)</p> Signup and view all the answers

What is the result of sudden separation of the placenta at birth?

<p>Hypoglycemia and attenuated lipolysis (D)</p> Signup and view all the answers

What is the primary mechanism by which maternal diabetes affects the fetus?

<p>Maternal hyperglycemia leads to fetal hyperglycemia (C)</p> Signup and view all the answers

What is a common clinical manifestation of infants of diabetic mothers (IDM)?

<p>Macrosomia (D)</p> Signup and view all the answers

What is the pathophysiological mechanism underlying fetal acidosis?

<p>Maternal hyperglycemia and fetal hyperinsulinemia (A)</p> Signup and view all the answers

What is the incidence of hypoglycemia in infants of diabetic mothers (IDM)?

<p>25-50% (C)</p> Signup and view all the answers

What is the possible reason for the higher incidence of respiratory distress syndrome (RDS) in IDM?

<p>Insulin's antagonistic effect on surfactant synthesis (C)</p> Signup and view all the answers

What is the primary approach to prevent macrosomic fetal growth and neonatal hypoglycemia?

<p>Strictly controlling maternal diabetes during pregnancy (C)</p> Signup and view all the answers

What is the percentage of cardiomegaly in infants of diabetic mothers?

<p>30% (D)</p> Signup and view all the answers

What is the incidence of congenital anomalies increased in infants of diabetic mothers?

<p>4 folds (B)</p> Signup and view all the answers

What is the characteristic of anencephaly?

<p>A birth defect in which a baby is born without parts of the brain and skull (C)</p> Signup and view all the answers

What is the long-term prognosis for infants of diabetic mothers in terms of physical development?

<p>Normal physical development (A)</p> Signup and view all the answers

What is the benefit of periconception glucose control in infants of diabetic mothers?

<p>Reducing the risk of anomalies and other adverse outcomes (C)</p> Signup and view all the answers

What is the characteristic of lumbosacral agenesis?

<p>A condition characterized by absence of different segments of lumbar spine along with total or partial absence of the sacrum (B)</p> Signup and view all the answers

What is the benefit of glucose control during labor in infants of diabetic mothers?

<p>Reducing the risk of neonatal hypoglycemia (A)</p> Signup and view all the answers

What is the treatment approach for infants of diabetic mothers?

<p>Initiating treatment before birth through frequent prenatal evaluation and planning of delivery (A)</p> Signup and view all the answers

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