Questions and Answers
What class does Dexmedetomidine belong to?
What is the primary indication for using Dexmedetomidine?
Sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting, and sedation of non-intubated patients before and/or during surgical and other procedures.
What is the mechanism of action of Dexmedetomidine?
Acts as a relatively selective alpha-adrenergic agonist with sedative properties.
What is the preparation concentration of Dexmedetomidine?
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The dose range for Dexmedetomidine is __________ mcg/kg/min.
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What are some hemodynamic effects of Dexmedetomidine?
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How is Dexmedetomidine primarily metabolized?
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What are some side effects of Dexmedetomidine?
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What are the nursing considerations when administering Dexmedetomidine?
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Study Notes
Dexmedetomidine Overview
- Class: Dexmedetomidine belongs to the category of sedatives, hypnotics, and analgesics.
- Indications include sedation for intubated and mechanically ventilated patients in intensive care; non-intubated patients undergoing surgical or other procedures.
Mechanism of Action
- Functions as a selective alpha-adrenergic agonist, providing sedative effects without significant respiratory depression.
Preparation Details
- Available in a single concentration of 400 mcg in 100 ml of Normal Saline.
Dosage Information
- Typical dose range is between 0.1 to 0.7 mcg/kg/min, with the possibility of increasing to a maximum of 1.5 mcg/kg/min upon medical direction.
- Dosing should be titrated to reach the desired sedation level.
Hemodynamic Effects
- Provides sedation and analgesia; monitoring of cardiovascular status is essential.
Metabolism and Pharmacokinetics
- Primarily metabolized by the liver, with some involvement of the P450 enzyme system.
- Onset is rapid; both peak and duration of effect are noted to be unknown.
- Half-life is approximately 2 hours.
Side Effects
- Cardiovascular side effects may include bradycardia, sinus arrest, hypotension, and transient hypertension.
Nursing Considerations
- Vigilance for signs of bradycardia and hypotension during administration is critical.
- Useful for transitioning patients from Propofol during extubation.
- Not associated with respiratory depression and can enhance the effects of morphine.
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Description
This quiz consists of flashcards focused on Dexmedetomidine, a sedative used in intensive care and surgical settings. Each card covers essential information, including the class, indications, and mechanism of action. Perfect for medical students and professionals looking to reinforce their knowledge.
