Developmental Biology Study Notes
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Questions and Answers

What happens to the endoderm during the development of the embryo?

  • It pinches off into the midline of the embryo. (correct)
  • It forms the umbilical cord.
  • It moves towards the yolk sac and remains there.
  • It migrates to the outer layer of the embryo.
  • What is the role of lateral body folding in embryonic development?

  • It forms the head and tail folds of the embryo.
  • It transforms the embryo disc into a cylindrical structure. (correct)
  • It develops the heart and pericardial sac.
  • It creates the gut tube from the yolk sac.
  • What does the connecting stalk develop into during embryonic growth?

  • The umbilical cord. (correct)
  • The heart.
  • The amniotic cavity.
  • The yolk sac.
  • By which day do the anterior and posterior neuropores close during embryonic development?

    <p>Day 28. (A)</p> Signup and view all the answers

    What occurs to the gut tube during lateral body folding?

    <p>It rolls up and separates from the yolk sac. (B)</p> Signup and view all the answers

    What is the primary role of the syncytiotrophoblast during implantation?

    <p>Invading the uterine cavity (C)</p> Signup and view all the answers

    Which germ layer does the epiblast ultimately develop into during gastrulation?

    <p>Ectoderm (B)</p> Signup and view all the answers

    What is the significance of the notochord during embryonic development?

    <p>It determines the body plan and induces the CNS to form (A)</p> Signup and view all the answers

    At which stage do the three germ layers - ectoderm, mesoderm, and endoderm - get formed?

    <p>Gastrulation (A)</p> Signup and view all the answers

    Which structure is formed by the migration of epiblast cells during gastrulation?

    <p>Primitive streak (A)</p> Signup and view all the answers

    What is the first tissue to form during the expansion of the bilaminar disc?

    <p>Notochord (A)</p> Signup and view all the answers

    What is the primary outcome of neurulation in embryonic development?

    <p>Formation of the brain and spinal cord (A)</p> Signup and view all the answers

    When does the foetus become fully formed?

    <p>By 3 months (C)</p> Signup and view all the answers

    What is the function of somites during embryonic development?

    <p>They provide support for the closure of the neural tube. (A)</p> Signup and view all the answers

    Which of the following structures do somites NOT contribute to?

    <p>Neurons in the central nervous system (A)</p> Signup and view all the answers

    When does the first somite appear during embryonic development?

    <p>Day 20 (D)</p> Signup and view all the answers

    What induces the formation of the neural plate during neurulation?

    <p>Notochord (A)</p> Signup and view all the answers

    How many somites are typically present by day 30 of embryonic development?

    <p>35 (A)</p> Signup and view all the answers

    Which part of the somite is responsible for forming muscle precursors?

    <p>Myotome (C)</p> Signup and view all the answers

    What is the fate of the anterior neuropore during embryonic development?

    <p>It is one of the last structures to close. (B)</p> Signup and view all the answers

    Which of the following is a consequence of neural crest cell absence during development?

    <p>Birth defects (B)</p> Signup and view all the answers

    What is the primary developmental stage in which most organs are formed during pregnancy?

    <p>1st trimester (D)</p> Signup and view all the answers

    What is the zona pellucida's role during fertilization?

    <p>Prevents multiple sperm from entering (D)</p> Signup and view all the answers

    What can be inferred if a defect is found in one tissue during development?

    <p>It is likely that other tissues are also affected. (A)</p> Signup and view all the answers

    During which phase does fertilization occur?

    <p>In the fallopian tube (D)</p> Signup and view all the answers

    Which statement is true regarding the inner cell mass during embryonic development?

    <p>It gives rise to every cell in the body. (C)</p> Signup and view all the answers

    What occurs if the inner cell mass fails to split during the twinning process?

    <p>The result is conjoined twins. (A)</p> Signup and view all the answers

    What is indicated by Holt-Oram syndrome in terms of structural development?

    <p>It indicates linked defects in multiple tissues. (B)</p> Signup and view all the answers

    What is the initial size of a zygote after fertilization?

    <p>Remains unchanged in size despite cell divisions. (C)</p> Signup and view all the answers

    What structure is formed by the fusion of the neural folds during neurulation?

    <p>Neural tube (C)</p> Signup and view all the answers

    Which germ layer is primarily responsible for developing into internal organs?

    <p>Endoderm (D)</p> Signup and view all the answers

    What leads to the development of spina bifida during neurulation?

    <p>Incomplete closure of the neural tube (B)</p> Signup and view all the answers

    Which process is described as the 'zipping up' of neural folds?

    <p>Neural tube closure (D)</p> Signup and view all the answers

    When does neurulation begin in human development?

    <p>Day 19 (C)</p> Signup and view all the answers

    What is the fate of the neuroectoderm during development?

    <p>Gives rise to neural tube and related structures (A)</p> Signup and view all the answers

    Which structure directly induces the ectoderm to become the neural plate?

    <p>Notochord (B)</p> Signup and view all the answers

    Which of the following is NOT derived from neural crest cells?

    <p>Internal organs (A)</p> Signup and view all the answers

    Flashcards

    Gastrulation

    Process transforming a bilaminar disc (2 layers) into a trilaminar embryo (3 layers) by forming the primitive streak and germ layers.

    Primitive streak

    A groove that forms in the epiblast at day 15/16, defining the embryo's development direction.

    Germ layers

    Ectoderm, mesoderm, and endoderm; the three fundamental layers formed during gastrulation, which give rise to different parts of the body.

    Notochord

    A structure important for neural tube formation. It induces ectoderm to become neural.

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    Neurulation

    The process of the neural tube forming from the neural plate.

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    Bilaminar disc

    A two-layered structure in the early embryo that develops into the trilaminar embryo.

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    Syncytiotrophoblast

    A part of the placenta that penetrates the uterus and enables embryo implantation

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    hCG

    A hormone produced during pregnancy that can be used for pregnancy detection

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    Bilaminar Disc (15 days)

    Early stage of embryonic development, a flat sheet of cells with two layers.

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    Primitive streak regression

    Movement of the primitive streak back toward its origin at the bottom of the embryo by day 21.

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    Neural Tube Formation (Neurulation)

    Process creating the central nervous system (CNS) by the folding of the neural plate.

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    Neural Crest Cells

    Cells formed at the crest of neural folds; migrate and form various tissues.

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    Neural Plate

    Thickened region of the ectoderm; precursor to the neural tube.

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    Embryonic Development

    The process of the embryo forming during the first 8 weeks after fertilization.

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    Organogenesis

    The process of forming organs during embryonic development.

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    Fertilization

    The union of sperm and egg to form a zygote.

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    Zygote

    The cell formed by the union of sperm and egg.

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    Inner Cell Mass

    The part of the blastocyst that develops into the embryo.

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    Identical Twins

    Twins formed from the same fertilized egg (zygote).

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    Holt-Oram Syndrome

    A genetic condition affecting heart and hand development due to a mutation affecting both.

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    Fertilization Location

    Fallopian tube, specifically the ampulla.

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    Head- & Tail-folds

    These folds form during embryonic development, tucking the heart ventrally, pinching off the gut tube from the yolk sac, and narrowing the body stalk. The head fold bends down, and the tail fold bends inwards. These folds contribute to the formation of the umbilical cord.

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    Lateral Body Folding

    This process transforms the flat embryonic disc into a 3D cylinder. It rolls up the gut tube, separating it from the yolk sac, and encloses the embryo completely except at the body stalk (forming the umbilical cord).

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    Amniotic Cavity

    This cavity surrounds the developing embryo except at the body stalk, which later forms the umbilical cord. It provides a protective environment for the embryo.

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    Connecting Stalk

    This structure connects the embryo to the uterus during early development. It is later transformed into the umbilical cord.

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    What forms the umbilical cord?

    The umbilical cord forms from the body stalk, which is the connection between the early embryo and the uterus. This stalk shrinks and becomes the cord, which connects the baby to the placenta.

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    Odontoblasts

    Cells responsible for forming dentin, the hard tissue beneath enamel in teeth.

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    Somites

    Blocks of mesoderm that form on either side of the neural tube during embryonic development. They give rise to muscles, vertebrae, cartilage, tendons, and skin.

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    Sclerotome

    Part of a somite that forms cartilage, tendons, and the vertebral column.

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    Myotome

    Part of a somite that forms muscle precursors.

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    Dermatome

    Part of a somite that forms skin precursors.

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    Neural Tube Closure

    The process where the neural folds meet in the midline, forming a closed tube that develops into the brain and spinal cord.

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    Otic Placode

    A thickened patch of ectoderm that will eventually form the inner ear.

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    Pericardial Bulge

    A bulge on the embryo's surface that will develop into the heart.

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    Study Notes

    Developmental Biology Study Notes

    • Why study development?

      • To understand how normal structures develop
      • To understand how abnormalities arise
      • To understand the positioning of adult structures
      • To recognize that defects in one structure can indicate defects in other structures (e.g., Holt-Oram syndrome)
      • To understand the relationship between structure/organ development for accurate diagnosis
    • Range of hand abnormalities Different variations in hand structure exist.

    • Phenotype and development

      • Mutations in genes required during development impact the development of multiple tissues
      • Understanding the relationships between development and organ systems can aid in diagnosis
      • Key development stages include embryonic development, fetal development, organogenesis, placental function and abnormalities noted at birth

    Human Development

    • Gestation period:

      • Humans require 9 months (40 weeks) to fully develop.
      • First trimester is critical for body formation.
        • Weeks 1-2: Blastocyst stage (early development)
        • Weeks 3-8: Embryonic stage (organ development)
        • Week 9 onward: Fetal stage (growth and maturation of physical processes)
      • Second trimester = rapid growth of the foetus
      • Third trimester = fat production and other physiological processes
    • Fertilization:

      • Occurs in the fallopian tube.
      • Sperm penetrate the egg's protective layers.
      • Fertilization triggers completion of meiosis and establishes the diploid chromosome number, determining the sex of the embryo.
      • Takes approximately 4 days to reach the uterine cavity.

    Early Human Development

    • Stages of embryonic development:

      • Zygote formation (fertilized egg)
      • Morula (early cell division stage)
      • Blastocyst (ball of cells with a fluid cavity)
      • Inner cell mass gives rise to all cells of the body
      • Various stages of cell divisions Twinning
    • Twinning:

      • Identical twins develop from a single fertilized egg dividing into separate structures
      • Fraternal twins develop from two distinct fertilized eggs.

    Post-fertilization

    • Zygote: The fertilized egg
    • Cleavage: Early cell divisions of the zygote
    • Blastocyst stage (important for twinning): development continues
    • Implantation: The blastocyst embedding itself in the uterus wall
    • hCG: Hormone to confirm pregnancy

    Blastocyst to Fetus Development

    • Blastocyst: Early embryonic stage, which differentiates into a foetus
    • Embryonic stage: A period of rapid development
    • Foetal stage: Continued growth and refinement
    • Stages: Fetal development occurs in three stages (9 days, 5-6 weeks, 3 months for example)

    Formation of Embryo/Fetus

    • Gastrulation: Cells rearrange to form three germ layers: ectoderm, mesoderm, and endoderm.
    • Germ layers: These layers give rise to various tissues and organs (ectoderm to skin and nervous system, mesoderm to muscles and skeleton, and endoderm to digestive system).
    • Neurulation & Neurulation: Formaiton of the neural tube and the nervous system.
    • Somite formation & Somitogenesis: Formation of blocks of tissue on either side of the neural tube, that eventually develop into bones, muscles, and connective tissues.

    19 days to 23 days

    • Closure of the neural tube
    • Formation of main body axes
    • Formation of organs and tissues, notably the heart and ear

    Lateral Body Folding

    • Folding of the embryo causes changes in shape from a flat disc to a cylindrical structure
    • The gut tube is separated from the yolk sac
      • Amniotic cavity completely surrounds the embryo

    Folding creates the embryo

    • Further development of the embryo occurs through different phases of folding that create the basic shape and structures needed for further development.
    • By day 28 of development, the majority of necessary structures have formed.

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    Description

    Explore the key concepts in developmental biology, focusing on the normal and abnormal development of structures. This quiz covers topics such as gestation periods, hand abnormalities, and the impact of genetic mutations on development. Understand the relationships between various organ systems and their development stages.

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