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Questions and Answers

Which somites transform back into the spread form after differentiation?

  • Sacral (correct)
  • All thoracical (correct)
  • All cervical
  • Lumbar (correct)

What is the correct order of events in retinal development?

  • Appearance of pigment retina, neural retina & intraretinal space (1) (correct)
  • Closure of intraretinal space (4) (correct)
  • Development of n.opticus (3) (correct)
  • Appearance of internal & external neuroblast layer (2) (correct)

Which of the following is the first muscle to develop in the eyeball?

  • Common primordial of inferior rectal and oblique
  • Superior rectal
  • Medial rectal (correct)
  • Lateral oblique

What structure does the ear placode give rise to?

<p>Membranous labyrinth (D)</p> Signup and view all the answers

What does the first pharyngeal pouch develop into?

<p>Tympanic cavity and Eustachian tube (A)</p> Signup and view all the answers

Which of the following events occurs first in the development of the external acoustic meatus?

<p>Development of the auricle (2) (A)</p> Signup and view all the answers

Which of the following are components of auricular structures?

<p>Tragus (B), Helix (C)</p> Signup and view all the answers

What does the membrane pupillaris represent?

<p>Remnant of posterior wall of anterior eye chamber (A)</p> Signup and view all the answers

What is the amount of rotation for the intestinal loop in the clockwise direction?

<p>90 degrees (C)</p> Signup and view all the answers

Which factor is NOT involved in the development of the secondary palate?

<p>FGF 10 (D)</p> Signup and view all the answers

Which of the following components is NOT typically found in a pharyngeal/branchial arch?

<p>Skin (C)</p> Signup and view all the answers

Which two ear bones are formed from the first arch?

<p>Malleus &amp; Incus (A)</p> Signup and view all the answers

From which pharyngeal/branchial arch does the tensor tympani muscle derive?

<p>First pharyngeal/branchial arch (C)</p> Signup and view all the answers

Which pharyngeal/branchial arch is associated with the common carotid artery?

<p>Third (A)</p> Signup and view all the answers

Which pharyngeal/branchial arch is associated with the facial nerve?

<p>Second (A)</p> Signup and view all the answers

What type of rotation occurs during herniation?

<p>45 degrees (B)</p> Signup and view all the answers

What develops from the dorsal primordium of the pancreas?

<p>Accessory pancreatic duct (C)</p> Signup and view all the answers

Which stage of lung development comes immediately after the saccular stage?

<p>Alveolar stage (B)</p> Signup and view all the answers

At what point during embryogenesis does the definitive oral cavity develop?

<p>2nd month (B)</p> Signup and view all the answers

Until which week of embryogenesis does the development of the reproductive system typically continue?

<p>10th week (B)</p> Signup and view all the answers

Which of the following structures contributes to the placental barrier?

<p>Syncytiotrophoblast (C)</p> Signup and view all the answers

Which branchial arch is the tongue primarily derived from?

<p>1st branchial arch (A)</p> Signup and view all the answers

Which zone is primarily responsible for the development of white matter in the brain?

<p>Marginal zone (D)</p> Signup and view all the answers

Which type of nerve is considered exclusively motor?

<p>N. facialus (D)</p> Signup and view all the answers

What is the primary source of the musculature of the tongue?

<p>Myoblasts of the 2nd branchial arch (C)</p> Signup and view all the answers

When do the papillae of the tongue begin to appear?

<p>Day 50 (B)</p> Signup and view all the answers

From which structures does the thyroid gland develop?

<p>Epithelial proliferation between the 1st and 2nd pharyngeal pouches (B)</p> Signup and view all the answers

Which statement about the development of the thymus is correct?

<p>Thymus primordia derive from the endoderm. (D)</p> Signup and view all the answers

Which branchial arch is most closely associated with the glossopharyngeal nerve?

<p>Third pharyngeal arch (C)</p> Signup and view all the answers

What does hyperdontia refer to?

<p>An increased number of teeth (C)</p> Signup and view all the answers

What is the most frequent malformation in the world?

<p>Cleft lip (C)</p> Signup and view all the answers

During which week does the development of the larynx, trachea, and lungs begin?

<p>4th week (B)</p> Signup and view all the answers

Which of the following is derived from the hindgut?

<p>Descending colon (A)</p> Signup and view all the answers

What is gastroschisis?

<p>Absence of the anterior body wall with urinary anomalies. (B)</p> Signup and view all the answers

When does the myelination process start?

<p>4th embryonic month (A)</p> Signup and view all the answers

Which structure does NOT contribute to the formation of the nasal cavity?

<p>Branchial arches (D)</p> Signup and view all the answers

What develops from the endoderm during respiratory system development?

<p>Glands of the lower respiratory system (A)</p> Signup and view all the answers

What is the primary influence on regional specification of the respiratory tract?

<p>Hoxa-3 to Hoxa-5 expression (C)</p> Signup and view all the answers

Which stage of development does the terminal alveolar sac and synthesis of surfactant occur?

<p>Saccular stage (B)</p> Signup and view all the answers

What role does the dorsal muscle mass play in muscle transformation?

<p>Transforms into the flexor muscles (C)</p> Signup and view all the answers

What are the appendix testis and utriculus prostaticus remnants of?

<p>Ductus mesonephricus (C)</p> Signup and view all the answers

When do nails cover the fingertips during embryogenesis?

<p>For upper limbs until week 36, lower limbs until week 32 (B)</p> Signup and view all the answers

From which structure do follicular cells develop?

<p>Coelomic epithelium (B)</p> Signup and view all the answers

What primarily happens during the mesenchymal stage of vertebral column development?

<p>Sclerotomes differentiate and migrate (C)</p> Signup and view all the answers

Where do secondary ossification centers for vertebrae primarily develop during the first postnatal year?

<p>On superior and inferior surfaces (A)</p> Signup and view all the answers

Desmal ossification is associated with which of the following skull bone types?

<p>Both types of viscerocranium bones (A)</p> Signup and view all the answers

When do lower limb primordials appear during embryogenesis?

<p>Around the 28th day (B)</p> Signup and view all the answers

At what stage does the spinal cord of the fetus reach the L1 vertebra?

<p>9th month (D)</p> Signup and view all the answers

What is the primary mechanism by which the epithelial seam of the palate disappears?

<p>Fusion of palate primordial (B)</p> Signup and view all the answers

Which event occurs last in the sequence of palatal development?

<p>Disappearance of the epithelial seam (C)</p> Signup and view all the answers

Gonocytes are primarily characterized as which type of cell?

<p>Undifferentiated oval cells (C)</p> Signup and view all the answers

What is a key factor in promoting intrauterine growth during development?

<p>Insulin (A)</p> Signup and view all the answers

What indicates male infertility regarding the number of spermatozoa in 1 ml of sperm?

<p>30 million sperm (A)</p> Signup and view all the answers

From which sources do the dermis and subcutis develop in the trunk?

<p>From dermatome and somites in the dorsal part (D)</p> Signup and view all the answers

Which glands are among the first to develop from skin derivatives?

<p>Sebaceous glands and hair follicles (D)</p> Signup and view all the answers

Flashcards

Somites that revert to spread form

Some somites, like cervical, thoracic, and lumbar, transition back to their original, wider state after initial differentiation.

Retinal development order - 1

Retina development starts with the formation of the internal and external neuroblast layers, then the pigment and neural retinas, and concludes with the closure of the intraretinal space.

First eye muscles

Initially, the eye's medial rectus, inferior rectus/oblique common primordium, and superior rectus muscles develop

Ear placode forms

Ear placode creates the membranous labyrinth

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1st pharyngeal pouch

This structure forms the tympanic cavity and Eustachian tube.

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Auricle formation order

Auricle development follows a specific order: first, tragus, helix, and concha development, followed by the meatus and final formation.

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Auricular structures

External ear parts include tragus, helix, and concha

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Membrane pupillaris

Membrane pupillaris is the remnant of the posterior wall of the anterior eye chamber.

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Intestinal Loop Rotation

The intestinal loop rotates during development, generally counterclockwise, by approximately 270 degrees.

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Secondary Palate Development

The development of the secondary palate is controlled by multiple factors, including Msx-1, BMP 2/4, and TGF beta 3.

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Pharyngeal Arch Components

A pharyngeal/branchial arch typically contains nerve, artery, vein, cartilage, bone, and muscle.

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Ear Bone Formation

The malleus and incus are formed together from the first pharyngeal arch.

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Tensor Tympani Muscle Origin

The tensor tympani muscle comes from the first pharyngeal arch.

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Common Carotid Artery Arch

The third pharyngeal/branchial arch is associated with the common carotid artery.

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Facial Nerve Arch

The second pharyngeal/branchial arch is associated with the facial nerve.

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Tongue Development

Development of the tongue involves multiple parts, including the fusion of various embryonic components.

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Main accessory duct of pancreas development

Developed from the dorsal primordium.

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Lung developmental stages

4 Alveolar, 2 Canalicular, 1 Pseudoglandular, and 3 Saccular stages are involved.

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Definitive oral cavity development

Occurs during the 2nd month of embryogenesis.

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Reproductive system development

Continues until the 12th week of embryogenesis.

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White matter development origin

Develops from the mantle zone.

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Placental barrier components

Consists of syncytotrophoblast, villi connective tissue, and the endothelium of capillaries.

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Motoric cranial nerves

Include oculomotorius, trochlearis, abducens, facialis, accessory, and hypoglossus nerves.

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Endometrial layer lining uterine cavity

Decidua parietalis.

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Appendix testis and utriculus prostaticus

Remnants of the ductus mesonephricus (Wolffian duct).

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Sebaceous glands development

Epidermal colbs that grow into the dermis. They are NOT hair epithelial vagina or excretory ducts of sweat glands.

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Nail development (embryogenesis)

Cover fingertips from birth (until the baby is born) for both upper and lower limbs.

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Follicular cells development

Develop from the cortex of the primitive gonad, not from the mesonephros or coelomic epithelium.

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Sclerotomes during mesenchymal stage of vertebral column

Differentiate and migrate during mesenchymal stage, characterized by loosely connected cells, NOT densely packed cells, and intervertebral space appearing later.

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Ureteric bud development

Develops into ureters and collecting urinary ducts, NOT nephrons.

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Secondary ossification centers for vertebrae

Develop on the processes during the first year after birth, not ventrally and dorsally. Not on superior and inferior surfaces.

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Desmal ossification (Skull bones)

Skull bones (mandible, maxilla and others) develop through desmal ossification, not the cartilaginous viscerocranium and membranous viscerocranium for example.

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Spinal Cord Development

The spinal cord, a crucial part of the nervous system, develops and extends during different stages of fetal development. It reaches the S1 vertebra by the 6th month and reaches the L1 vertebra by the 9th month.

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Palate Closure

The epithelial seam, a temporary structure, disappears during palate development due to cell migration and fusion. This process involves the migration of epithelial cells and the transformation of some of them into mesenchymal cells.

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Palate Development Order

The development of the palate involves a specific sequence of events: 1) Downward growth of the palatal primordia, 2) Elevation of the primordia, 3) Fusion of the primordia, 4) Disappearance of the epithelial seam, and 5) Desmal ossification and muscle differentiation.

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Gonocytes: Early Germ Cells

Gonocytes, the primordial germ cells, are round and undifferentiated at first. They lack alkaline phosphatase and glycogen, and exhibit ameboid-like movement and undulation.

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Spermiogenesis: The Final Stage

Spermiogenesis refers to the final phase of sperm development, where spermatids undergo a transformation to become mature spermatozoa, acquiring their characteristic head, midpiece, and tail.

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Intrauterine Growth Inducers

Various growth factors play a role in intrauterine growth, with IGF (Insulin-like Growth Factor), HGF (Hepatocyte Growth Factor), and BMP 2/4 (Bone Morphogenetic Protein) being some of the strongest inducers.

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Male Infertility Indicator

A low sperm count, typically considered below 30 million spermatozoa per milliliter of semen, is a suggestive indicator of male infertility.

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Dermis and Subcutis Development

Dermis and subcutis, crucial layers of the skin, develop from different regions of the embryonic mesoderm. In the dorsal trunk, they originate from the dermatome and somites, while in the lateral/ventral trunk, they develop from the lateral mesoderm.

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Tongue Musculature Origin

The tongue's muscles develop from cranial somites.

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Tongue Body Development

The body of the tongue forms from three lingual swellings.

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Tongue Root Origin

The tongue's root originates from the 2nd, 3rd, and 4th branchial arches.

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Tongue Papillae Appearance

Tongue papillae become visible around day 50 of development.

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Thyroid Gland Origin

The thyroid gland develops from tissue between the 1st and 2nd pharyngeal pouches.

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Thymus Primordia Origin (incorrect)

The thymus primordia primarily originate from ectoderm and mesenchyme.

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Glossopharyngeal Nerve Association

The glossopharyngeal nerve is most closely associated with the the 3rd pharyngeal/branchial arch.

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Hyperdontia Definition

Hyperdontia is an increased number of teeth.

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Cleft Lip/Palate Frequency

Cleft lip and palate is the second most common birth defect.

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Cleft Lip Cause

Cleft lip results from a failure of the maxillary and nasal processes to fuse.

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Larynx, Trachea, Lungs Development

Larynx, trachea, and lungs develop during the 4th week (part of the early development).

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Lower Respirtory System Epithelium Origin

The epithelium of the lower respiratory system is derived from endoderm.

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Respiratory Tract Regional Specificity

Hoxa-3 to Hoxa-5 genes determine the regions of the respiratory tract.

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Bronchial Tree Development Stage

The development of the bronchial tree, including terminal bronchioles occurs during the pseudoglandular stage.

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Terminal Alveolar Sac Development

Formation of the terminal alveolar sacs and surfactant synthesis occur during the saccular stage.

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Larynx Developmental Origin

The larynx develops mainly from the 4th and 6th branchial arches.

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Hindgut Blood Supply

The hindgut primarily receives its blood supply from the inferior mesenteric artery.

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