Development of the Nervous System
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Questions and Answers

From which embryonic tissue does the nervous system develop?

  • Endoderm
  • Ectoderm (correct)
  • Neuroectoderm
  • Mesoderm
  • What structure induces the development of the neural plate during embryonic development?

  • Neural groove
  • Notochord (correct)
  • Neural crest
  • Neural folds
  • What is the term for the process by which the neural tube is formed from the neural plate?

  • Secondary neurulation
  • Neural migration
  • Primary neurulation (correct)
  • Neural differentiation
  • Which part of the neural plate will ultimately develop into the brain?

    <p>Broader anterior end</p> Signup and view all the answers

    What structure forms when cells from the lateral margin of the neural groove migrate?

    <p>Neural crest</p> Signup and view all the answers

    Which of the following processes occurs as the neural plate grows and widens?

    <p>Formation of the neural crest</p> Signup and view all the answers

    When during embryonic development do significant changes in the neural plate occur?

    <p>Third to fourth week</p> Signup and view all the answers

    What does the neural groove become as it deepens during development?

    <p>Neural tube</p> Signup and view all the answers

    Which group of neural crest cells differentiates into sensory neurons of cranial nerve ganglia?

    <p>Dorsal root ganglia cells</p> Signup and view all the answers

    What is the condition resulting from the failure of the anterior neuropore to close?

    <p>Anencephaly</p> Signup and view all the answers

    Which cells are formed from the neural crest and are critical for myelin formation in peripheral nerves?

    <p>Schwann cells</p> Signup and view all the answers

    What develops from the mesodermal somites adjacent to the neural tube?

    <p>Skeletal muscle and vertebrae</p> Signup and view all the answers

    Which condition results from the failure of the posterior neuropore to close?

    <p>Spina bifida</p> Signup and view all the answers

    Holoprosencephaly affects which part of the developing embryo?

    <p>Forebrain</p> Signup and view all the answers

    Which of the following nervous system components is composed of postganglionic neurons of the sympathetic and parasympathetic systems?

    <p>Autonomic ganglion cells</p> Signup and view all the answers

    From which embryonic structure do the dorsal root ganglia derive?

    <p>Neural crest</p> Signup and view all the answers

    What is the first layer of the forming neural tube to appear?

    <p>Ventricular zone</p> Signup and view all the answers

    In the brainstem, where are motor nuclei positioned in relation to the sulcus limitans?

    <p>Medial to the sulcus limitans</p> Signup and view all the answers

    What condition is characterized by the absence of the vertebral lamina, allowing for the exposure of meninges?

    <p>Spina bifida occulta</p> Signup and view all the answers

    What developmental feature is formed by the fusion of rhombic lips at the midline?

    <p>Cerebellum</p> Signup and view all the answers

    What characterizes the condition known as encephalocele?

    <p>Protrusion of the meninges</p> Signup and view all the answers

    Which embryonic age correlates with significant brain development changes, such as in the cerebral cortex?

    <p>36 days old</p> Signup and view all the answers

    In human brain development, which of the following is considered the last major phase of development before birth?

    <p>3 months</p> Signup and view all the answers

    Which brain structure is notably organized in a medial-to-lateral arrangement of nuclei?

    <p>Brainstem</p> Signup and view all the answers

    Study Notes

    Development of the Nervous System

    • The nervous system originates from ectoderm, the outermost embryonic layer.
    • By the third to fourth week of development, the notochord from mesoderm induces the neural plate's formation.
    • Rapid cell proliferation occurs as the neural plate thickens and expands laterally.

    Neural Tube Formation

    • The neural plate creates a longitudinal neural groove, further deepening as development progresses.
    • The anterior end of the neural plate forms the brain, while the posterior end becomes the spinal cord.
    • Primary neurulation takes place when the neural folds fuse, forming the neural tube.

    Neural Crest Cell Differentiation

    • Neural crest cells migrate and differentiate into various neuron types:
      • Sensory neurons of cranial nerve ganglia (CN V, VII, IX, X) and dorsal root ganglia.
      • Autonomic ganglion cells for sympathetic and parasympathetic systems.
      • Other neural crest derivatives include chromaffin cells, Schwann cells, and melanocytes.
    • Surrounding mesodermal tissues, called somites, develop into skeletal muscle, vertebrae, and dermal skin layers.

    Neural Tube Defects

    • Failure of the anterior neuropore closure results in anencephaly; posterior neuropore closure failure leads to spina bifida.

    Brain Vesicle Development

    • Three primary brain vesicles form, leading to five secondary vesicles; these are essential for forebrain development.
    • The forebrain's development is critical during the fifth and sixth weeks of gestation.

    Holoprosencephaly (HPE)

    • HPE is a disorder where the prosencephalon does not split into two hemispheres, impacting forebrain and facial development.

    Cortical Development

    • The cerebral cortex undergoes early and later development stages, transitioning from 28 days to nine months.

    Spinal Cord and Brainstem Development

    • The ventricular zone is the first proliferative layer of the neural tube, followed by the marginal and mantle layers.
    • Cranial nerve nuclei organization in the brainstem is defined by the sulcus limitans, separating sensory and motor nuclei.

    Cerebellum Development

    • The cerebellum forms from the rhombic lips fusing at midline during brainstem maturation.

    Spina Bifida and Encephalocele

    • Spina bifida occulta features a failure of the posterior vertebral arch to close, exposing meninges.
    • Encephalocele involves cranial defects leading to meninges herniation.

    Anencephaly

    • Anencephaly is characterized by significant malformation of the brain, resulting from neural tube defect.

    Occipital Encephalocele

    • Occipital encephalocele is a herniation of cranial contents through a defect in the skull, typically affecting the occipital region.

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    Description

    Explore the intricate process of the nervous system's development. From the formation of the neural plate to the differentiation of neural crest cells, this quiz covers key stages in neural tube formation and cell migration. Test your knowledge on how these elements contribute to the overall structure of the nervous system.

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