Ch7-Lifespan Development
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Questions and Answers

What is the process called where precursor cells develop into neurons and glial cells?

  • Synaptogenesis
  • Apoptosis
  • Neurogenesis (correct)
  • Myelination
  • During which developmental stage does the neural plate start to form the neural tube?

  • Neurulation (correct)
  • Gastrulation
  • Embryonic stage
  • Fetal development
  • What initiates the migration of neural crest cells during nervous system development?

  • Neural tube formation
  • Chemical signals (correct)
  • Apoptosis
  • Cell division
  • Which process involves the elimination of excess neurons during development?

    <p>Apoptosis (B)</p> Signup and view all the answers

    What is primarily responsible for the formation and maturation of synapses during development?

    <p>Synaptogenesis (A)</p> Signup and view all the answers

    Which of the following factors can influence neuron survival during development?

    <p>Biochemical signaling (B)</p> Signup and view all the answers

    What characteristic does the neural tube division create for future brain development?

    <p>Division into specialized regions (C)</p> Signup and view all the answers

    At what stage does the notochord play a crucial role in nervous system development?

    <p>Formation of neural plate (D)</p> Signup and view all the answers

    Which developmental process involves the reorganization of synaptic connections?

    <p>Synaptic rearrangement (A)</p> Signup and view all the answers

    What stage follows the gastrula in embryonic development?

    <p>Embryo (A)</p> Signup and view all the answers

    What is one consequence of visual enrichment on the brain's structure?

    <p>Thicker cortex (D)</p> Signup and view all the answers

    During which time frame does monocular deprivation significantly affect the organization of ocular dominance in the primary visual cortex?

    <p>3 weeks to 6 weeks (B)</p> Signup and view all the answers

    Which process involves the addition of a methyl group to suppress gene expression?

    <p>DNA methylation (B)</p> Signup and view all the answers

    What experience-related factor significantly influences the expression of the GR promoter in the hippocampus of offspring of certain rat mothers?

    <p>Decreased methylation (D)</p> Signup and view all the answers

    In the context of aging, which cognitive function typically shows decline?

    <p>Long-term memory (A)</p> Signup and view all the answers

    What is the common characteristic of neurofibrillary tangles found in Alzheimer's Disease?

    <p>Pairs of twisted hyper-phosphorylated tau filaments (A)</p> Signup and view all the answers

    What is not a protective factor against age-associated memory impairment (AAMI)?

    <p>History of depression (A)</p> Signup and view all the answers

    What happens to dendritic spines as a result of estrogen loss in aging females?

    <p>Reduction in growth and formation (D)</p> Signup and view all the answers

    What is the role of glucocorticoids in relation to the hippocampus?

    <p>Cause hippocampal atrophy (D)</p> Signup and view all the answers

    Which statement about the genetic basis of Alzheimer's Disease (AD) is accurate?

    <p>Three autosomal dominant gene mutations are identified for early onset AD. (B)</p> Signup and view all the answers

    What is one effect of competitive synapse activity during development?

    <p>Active synapses predominating over inactive ones (A)</p> Signup and view all the answers

    What is a notable feature of vascular or multi-infarct dementia?

    <p>Small strategically placed lacunes can also severely affect cognition. (A)</p> Signup and view all the answers

    What is a consequence of oxidative damage and inflammatory responses during aging?

    <p>Increased reactive state of microglia (A)</p> Signup and view all the answers

    Which of the following factors is correlated with cognitive decline as individuals age?

    <p>The presence of neurofibrillary tangles (C)</p> Signup and view all the answers

    Which process involves the movement of precursor cells to their final locations in the developing nervous system?

    <p>Migration (C)</p> Signup and view all the answers

    What is the main role of the radial glia during migration in the central nervous system?

    <p>Act as a scaffold for outward migration (D)</p> Signup and view all the answers

    In synaptogenesis, what process describes the interaction between growth cones and guiding molecules?

    <p>Fasciculation (A)</p> Signup and view all the answers

    What initiates the process of apoptosis in developing neurons?

    <p>Lack of appropriate target contact (C)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of Bcl-2 proteins in apoptosis?

    <p>They prevent the release of Diablo from the mitochondria. (B)</p> Signup and view all the answers

    What occurs during synaptic rearrangement in developing neural circuits?

    <p>Surviving neurons fill open synaptic spaces. (B)</p> Signup and view all the answers

    What is the primary role of chemoaffinity in synaptogenesis?

    <p>To guide the growth of axons towards their targets (C)</p> Signup and view all the answers

    What happens to cells that fail to make appropriate connections in the nervous system?

    <p>They are eliminated through apoptosis. (C)</p> Signup and view all the answers

    Which of the following best describes the competitive nature of neuronal survival?

    <p>Neurons that do not receive enough growth factors will be eliminated. (C)</p> Signup and view all the answers

    What occurs during the process of myelination in neural development?

    <p>A protective sheath is formed around the neuron. (B)</p> Signup and view all the answers

    Which stage of neural development includes the differentiation of precursor cells into specialized cell types?

    <p>Differentiation (C)</p> Signup and view all the answers

    What is a potential effect of environmental impoverishment on the visual cortex?

    <p>Fewer synapses and spines. (C)</p> Signup and view all the answers

    What is the significance of topographic gradients during synaptic rearrangement?

    <p>They guide consistent mapping of source to target in neural circuits. (A)</p> Signup and view all the answers

    Which cellular structure is primarily altered during apoptosis?

    <p>Nucleus (C)</p> Signup and view all the answers

    Flashcards

    Neurogenesis

    The production of new nerve cells.

    Migration (neurons)

    The movement of neurons to their final locations.

    Differentiation (neurons)

    Neurons change their type and develop specialized characteristics.

    Synaptogenesis

    The formation of synapses (connections) between neurons.

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    Apoptosis

    Programmed cell death, crucial for development.

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    Synaptic Rearrangement

    Refinement of synaptic connections between neurons.

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    Myelination

    Formation of myelin sheaths around axons (some neurons).

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    Radial Glia

    Scaffolding cells guiding neuron migration.

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    Chemoaffinity

    Attraction of axons to specific target cells based on chemical cues.

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    Fasciculation

    Stereotyped axonal pathfinding guided by pioneer axons.

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    Competitive neuronal survival

    Only neurons that make proper connections survive.

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    Synaptic rearrangement

    Modifying existing synaptic connections.

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    Topographic gradients

    Maintaining the organization of neuronal maps.

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    Environmental enrichment

    Improved environment promotes synaptic connections.

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    Visual deprivation

    Lack of visual input impairs brain development.

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    Enriched environment effect on the brain

    A richer environment promotes a thicker cortex, more dendrites, and more synapses, leading to better brain development.

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    Visual deprivation effect

    Reduced visual input leads to fewer synapses and spines in the visual cortex, causing problems with depth and pattern perception.

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    Ocular dominance

    The preference of a brain area for signals from one eye.

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    Sensitive period (brain development)

    A specific time frame during development where the brain is most susceptible to environmental influences and experiences.

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    Monocular deprivation effects (sensitive period)

    Significant shifts in brain's ocular dominance happen quickly early in life.

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    DNA methylation

    Adding a methyl group to DNA to control gene expression.

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    Histone acetylation

    Modifying histones (proteins DNA wraps around), affecting how tightly DNA is packed, and impacting gene expression.

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    Epigenetics

    The study of how environmental factors influence the activation of genes, without changing the underlying DNA sequence itself.

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    Age-associated memory impairment (AAMI)

    Memory issues that result in aging, ranging from mild to profound dementia.

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    Vascular multi-infarct dementia

    Dementia caused by a series of small strokes.

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    Stress and hippocampal atrophy

    High stress and glucocorticoids may shrink the hippocampus in the brain.

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    Alzheimer's Disease

    A common age-associated dementia characterized by amyloid plaques and neurofibrillary tangles.

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    Amyloid plaques

    Deposits of abnormal protein fragments in the brain.

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    Neurofibrillary tangles

    Twisted protein fibers inside brain cells that disrupt function.

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    Zygote

    A single cell formed by the fusion of a sperm and an egg.

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    Blastocyst

    A hollow sphere of cells that develops from the zygote. It has the potential to become any type of cell in the body.

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    Gastrula

    A three-layered structure that develops from the blastocyst. These layers give rise to different tissues and organs.

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    Ectoderm

    The outermost layer of the gastrula, which develops into the nervous system, skin, and hair.

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    Mesoderm

    The middle layer of the gastrula, which develops into muscles, bones, and blood.

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    Endoderm

    The innermost layer of the gastrula, which develops into the digestive system and lungs.

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    Neural Plate

    A thickening of the ectoderm that forms the neural tube, the precursor to the central nervous system.

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    Neural Tube

    A tube formed from the neural plate that develops into the brain and spinal cord.

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    Neural Crest Cells

    Cells that break off from the neural tube during development and form the peripheral nervous system.

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    Sensory Placodes

    Patches of thickened ectoderm that give rise to sensory organs like the eyes and ears.

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    Study Notes

    Development of the Nervous System

    • Nervous system development involves seven key processes: neurogenesis, migration, differentiation, synaptogenesis, apoptosis, synaptic rearrangement, and myelination.
    • Experience and epigenetics play a role in development, affecting aging as well.
    • Ongoing neurogenesis, vascular dementia, stress and Alzheimer's disease are factors linked with aging of the nervous system.

    Stages of Development

    • Zygote: A fertilized egg, a single cell.
    • Blastocyst: A hollow sphere of stem cells with pluripotential capabilities.
    • Gastrula: A three-layered form resulting from a partially differentiated blastocyst.
    • Embryo: Composed of three layers—ectoderm, mesoderm, and endoderm.
    • Fetus: Recognizable in relation to its mature form.

    Neurulation

    • Neurulation involves the dorsal epithelial layer (ectoderm) thickening to form a neural plate.
    • The neural plate folds to create a neural groove and neural tube, which ultimately forms the central nervous system.
    • This occurs around 18-22 days.

    Cells of the Nervous System

    • Neural crest cells break off during neurulation and migrate, forming the peripheral nervous system, guided by chemical signals.
    • Sensory organs originate, at least partly, from sensory placodes. These include olfactory, lens, trigeminal, geniculate, epibranchial, petrosal, and otic placodes.

    Cell Migration

    • Cells of the neural crest migrate to their final destinations guided by chemical signals, contributing to the peripheral nervous system's structure.
    • Important to note that migration occurs in waves, with different waves creating different regions of the brain.

    Differentiation

    • Dividing pluripotent cells differentiate into non-dividing neuroblasts and glioblasts.
    • The cells mature into specialized neurons or glial cells.
    • Remaining ventricular cells differentiate into ependymal cells lining the ventricles and spinal cord.
    • Different cell types undergo different processes depending on their location and function.

    Synaptogenesis

    • Synaptogenesis involves the growth of axons, dendrites, and synapses.
    • Filopodial structures from growth cones extend and contract.
    • Target cells release chemical labels that attract growing axons.
    • Pioneer growth cones interact with NCAMs to guide subsequent neurons' growth, creating stereotyped axonal paths and making a complex structure in a consistent way.

    Apoptosis

    • Exuberant cell proliferation in early development is followed by programmed cell death (apoptosis).
    • Cells not contacting their appropriate target undergo apoptosis.
    • Glial cells can undergo apoptosis, and progenitor cell careers end due to apoptosis.

    Synaptic Rearrangement

    • Neurons that fire together wire together (Hebbian principle).
    • Synaptic contacts become more focused over time.
    • Synaptic density peaks around one year of age and then decreases.
    • Throughout prenatal and postnatal life, and across the different stages of development, patterns of synaptic contact shift.

    Myelination

    • Myelination, the formation of myelin sheaths, starts around 24 weeks after conception.
    • It begins in the spinal cord and progresses to other brain regions.
    • A high-intensity phase of myelination occurs in the early postnatal period.
    • Myelin sheath formation occurs in stages and may vary across regions.

    Environmental Influences

    • Environmental enrichment promotes thicker cortex, more dendrites, and more synapses.
    • Visual deprivation results in fewer synapses and spines in primary visual cortex, leading to deficits in visual perception.
    • Experience significantly shapes the functional organization of the brain, particularly in the visual cortex.

    Aging

    • Aging continues neurogenesis and migration in specific areas (hippocampus, caudate nucleus, olfactory bulb).
    • Age-associated memory impairment (AAMI) varies from mild cognitive impairment to profound dementia.
    • Cognitive function remains intact until advanced age in most individuals.
    • Age-related changes can affect the ability to acquire and store new information.
    • Factors such as education and profession may influence AAMI risk factors, while mood and depression are significant correlates to cognitive decline.

    Alzheimer's Disease

    • Alzheimer's disease is the most common form of age-related dementia.
    • It involves the accumulation of amyloid plaques and neurofibrillary tangles.
    • The disease often starts in the hippocampus and overlying cortical areas and progressively spreads.
    • Genetic factors, like mutations in amyloid precursor protein genes or certain alleles of the apolipoprotein E gene, influence both early-onset and late-onset types.
    • Early-stage symptoms often involve difficulties with memory, language, and identification of objects or words.
    • In later stages, patients may become mute and severely disabled.

    Epigenetics

    • Epigenetics describe how experiences affect gene expression throughout a lifespan.
    • DNA methylation, adding methyl groups to DNA, can turn off genes in a stable way.
    • Histone acetylation affects how tightly DNA is wrapped around proteins and is involved in gene activity, which is affected by environmental factors.
    • There are also wider influences, including development, environmental chemicals, pharmaceuticals, diet, and aging.

    Vascular Dementia

    • Vascular dementia can be caused by larger infarcts (>50ml) or smaller lacunar infarcts (1ml).
    • Risk factors include hyperlipidemia, diabetes mellitus, hyperhomocysteinemia, smoking, elevated C-reactive protein, cerebral amyloid angiopathies.

    Hippocampus Atrophy

    • Chronic stress and elevated glucocorticoids can lead to hippocampal atrophy.
    • This is likely due to shrinkage in dendritic arborization.

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    Description

    This quiz focuses on the key processes involved in the development of the nervous system, including neurogenesis, synaptogenesis, and myelination. It also covers the stages of development from zygote to fetus and the process of neurulation. Test your understanding of these essential concepts in neurodevelopment.

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