Development of the Face - Anatomy Quiz

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Questions and Answers

What structure develops from the proliferation of mesenchyme in the margins of the nasal placodes?

  • Nasal pits
  • Lateral nasal prominences (correct)
  • Maxillary prominences
  • Auricular hillocks

What is the role of PDGFRA signaling in the development of the facial region?

  • Guiding the movement of the medial nasal prominences towards the median plane (correct)
  • Regulating the development of the auricular hillocks
  • Controlling the proliferation of mesenchyme in the maxillary prominences
  • Directing the fusion of the maxillary and lateral nasal prominences

What is the primordium of the anterior nares?

  • Lateral nasal prominences
  • Maxillary prominences
  • Nasal placodes
  • Nasal pits (correct)

What is the structure that forms the side of the nose?

<p>Lateral nasal prominences (B)</p> Signup and view all the answers

What is the structure that develops from the rod-like thickening of ectoderm in the floor of the nasolacrimal groove?

<p>Nasolacrimal duct (D)</p> Signup and view all the answers

Which of these structures contributes to the formation of the cheek region?

<p>Maxillary prominence (D)</p> Signup and view all the answers

What is the significance of the nasolacrimal groove in facial development?

<p>It establishes continuity between the side of the nose and the cheek region. (D)</p> Signup and view all the answers

Which of the following statements is true regarding the development of the external ear?

<p>The external ears are formed from three mesenchymal swellings on each side. (B)</p> Signup and view all the answers

Which cranial nerve supplies the muscles of mastication?

<p>Trigeminal Nerve (CN V) (A)</p> Signup and view all the answers

During which stage of development do the maxillary sinuses begin to develop?

<p>Late fetal life (A)</p> Signup and view all the answers

What is the main function of the paranasal sinuses?

<p>To provide resonance to the voice (A)</p> Signup and view all the answers

At what age do the frontal sinuses typically become visible in radiographs?

<p>Around 7 years of age (C)</p> Signup and view all the answers

Which of the following paranasal sinuses is NOT present at birth?

<p>Frontal sinuses (B), Sphenoidal sinuses (D)</p> Signup and view all the answers

Which of the following molecular pathways are involved in palatogenesis?

<p>WNT and PRICKLE1 (C)</p> Signup and view all the answers

What is the primary function of the muscles of facial expression?

<p>Controlling facial movements (D)</p> Signup and view all the answers

Which of the following structures develops from the second pharyngeal arch?

<p>Muscles of facial expression (A)</p> Signup and view all the answers

What is the sequence of events in the development of the nasal septum and palatine processes?

<p>Fusion begins anteriorly during the 9th week and is completed by the 12th week. (B)</p> Signup and view all the answers

Which structure gives rise to the dental buds in tooth development?

<p>The dental lamina. (D)</p> Signup and view all the answers

What marks the transition from the cap stage to the bell stage of tooth development?

<p>The deep indentation of the dental buds. (D)</p> Signup and view all the answers

What is the role of odontoblasts in tooth development?

<p>They produce dentin. (D)</p> Signup and view all the answers

What gives the inner dental epithelium its ability to differentiate into ameloblasts?

<p>The structure of the dental cap. (A)</p> Signup and view all the answers

Which layer of the tooth persists throughout the life of the tooth?

<p>Odontoblast layer. (A)</p> Signup and view all the answers

How does the shape of the face develop in relation to teeth?

<p>By the growth of the mandible, maxilla, and expansion of paranasal sinuses. (A)</p> Signup and view all the answers

At what week does the dental lamina first form in oral cavity development?

<p>6th week. (C)</p> Signup and view all the answers

What is the critical period of palatogenesis?

<p>From the end of the sixth week to the beginning of the ninth week (A)</p> Signup and view all the answers

Which structures form the primary palate?

<p>Medial nasal prominences and maxillary prominences (D)</p> Signup and view all the answers

What part of the adult hard palate does the primary palate represent?

<p>The anterior part of the palate (B)</p> Signup and view all the answers

During which weeks do the lateral palatine processes assume a horizontal position?

<p>Seventh and eighth weeks (D)</p> Signup and view all the answers

Which part of the palate is primarily formed from the lateral palatine processes?

<p>Hard and soft palate (B)</p> Signup and view all the answers

What structure does the nasopalatine canal represent in the adult hard palate?

<p>Incisive fossa (B)</p> Signup and view all the answers

What occurs to the posterior parts of the lateral palatine processes during palatogenesis?

<p>They extend posteriorly and fuse to form the soft palate. (B)</p> Signup and view all the answers

Which structure indicates the line of fusion of the palatine processes?

<p>Palatine raphe (B)</p> Signup and view all the answers

What structure regulates early tooth development?

<p>Enamel knot (A)</p> Signup and view all the answers

Where is enamel first laid down during tooth development?

<p>At the apex of the tooth (A)</p> Signup and view all the answers

Which cells differentiate into cementoblasts during tooth development?

<p>Mesenchymal cells (D)</p> Signup and view all the answers

What happens to the pulp chamber as more dentin is deposited?

<p>It narrows (D)</p> Signup and view all the answers

What function does the periodontal ligament serve?

<p>Holds the tooth in position and acts as a shock absorber (A)</p> Signup and view all the answers

When do buds for permanent teeth begin to grow?

<p>Approximately the sixth year of postnatal life (A)</p> Signup and view all the answers

What occurs to the root of a deciduous tooth as the permanent tooth grows?

<p>It is resorbed by osteoclasts (B)</p> Signup and view all the answers

What structure forms a thin membrane on the surface of the enamel after ameloblasts retreat?

<p>Dental cuticle (C)</p> Signup and view all the answers

Which of the following structures is NOT involved in the development of the face?

<p>choroid plexus (B)</p> Signup and view all the answers

What is the primary source of connective tissue components, such as cartilage, bone, and ligaments, in the facial and oral regions?

<p>Neural crest cells (A)</p> Signup and view all the answers

During which developmental stage does the face begin to develop?

<p>Fourth week (D)</p> Signup and view all the answers

What is the role of the frontonasal prominence in facial development?

<p>Forms the forehead and nasal region (A)</p> Signup and view all the answers

Which of the following statements is TRUE about the development of the face?

<p>The lower jaw and lower lip form first. (D)</p> Signup and view all the answers

What is the significance of the sonic hedgehog morphogenic gradients in facial development?

<p>They guide the migration of neural crest cells. (A)</p> Signup and view all the answers

What is the primary factor driving the growth of facial prominences?

<p>Expansion of neural crest cells (B)</p> Signup and view all the answers

During which developmental stage does the face achieve a human-like appearance?

<p>Embryonic period (A)</p> Signup and view all the answers

Flashcards

Critical period of palatogenesis

The period of development where the palate forms, lasting from the end of the sixth week to the beginning of the ninth week.

Primary palate

The front part of the palate, formed by the merging of the medial nasal prominences. It comprises the premaxillary part of the maxilla, which houses the incisor teeth.

Secondary palate

The back part of the palate, where the hard and soft palates form.

Lateral palatine processes

The lateral palatine processes, which are mesenchymal projections extending from the maxillary prominences, form the secondary palate.

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Fusion of palatine processes

The process where the lateral palatine processes, after extending from the maxillary prominences, assume a horizontal position above the tongue and fuse to form the hard and soft palates.

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Palatine raphe

The line of fusion of the palatine processes, indicated by a noticeable groove along the midline of the palate.

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Nasopalatine canal

A small canal located between the anterior part of the maxilla and the palatine processes, persisting in the median plane of the palate.

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Incisive fossa

A depression on the adult hard palate, representing the former nasopalatine canal.

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Palatogenesis

The development of the palate, beginning in the sixth week and completing by the 12th week of gestation. This process involves fusion of two structures: the primary palate and the secondary palate.

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Paranasal sinuses

A group of air-filled cavities within the skull that connect to the nasal cavity. They grow and develop after birth and contribute to the shape and size of the face.

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Maxillary sinuses

The largest of the paranasal sinuses, located within the maxillary bones. They are present at birth and continue to grow until adulthood.

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Frontal sinuses

The sinuses found within the frontal bones. They develop after birth and usually become visible on X-rays around the age of 7.

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Ethmoidal cells

The sinuses within the ethmoid bone, located near the nose. They begin to grow rapidly around 6-8 years of age.

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Sphenoidal sinuses

The sinuses within the sphenoid bone, located behind the ethmoid cells. They develop after birth and grow into the sphenoid bone.

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What is the stomodeum?

The first stage in the development of the mouth, forming the primitive mouth cavity. It forms from the depression in the ectoderm that gives rise to the oral cavity.

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What does the frontonasal prominence give rise to?

The frontonasal prominence surrounds the developing forebrain and gives rise to the forehead and the nose.

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What do the maxillary prominences form?

The maxillary prominences form the lateral boundaries of the stomodeum and give rise to the upper jaw and cheekbones.

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What structures are formed by the mandibular prominences?

The mandibular prominences form the caudal boundary of the stomodeum and give rise to the lower jaw (mandible) and lower lip.

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How is the lower jaw and lower lip formed?

The fusion of the medial ends of the mandibular prominences in the median plane. This process forms the lower jaw and lower lip.

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What is a common chin dimple caused by?

A dimple located on the chin that results from incomplete fusion of the mandibular prominences.

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When does the face develop its human appearance?

The development of facial features occurs during the embryonic period, mainly between the fourth and eighth weeks. By the end of that period, the face has a human appearance.

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When do facial features change from a basic human appearance?

The proportions of facial features develop during the fetal period. This is after the facial features have a basic human appearance.

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Enamel Knot

A cluster of cells in the inner dental epithelium that plays a crucial role in regulating the early stages of tooth development.

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Enamel

The outermost layer of the tooth, formed by ameloblasts, which is the hardest tissue in the human body.

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Dental Cuticle

A thin membrane left on the tooth surface after ameloblasts retreat, which eventually sloughs off after tooth eruption.

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Cementum

A layer of specialized bone that covers the tooth root, attaching it to the periodontal ligament.

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Dental Pulp

A specialized tissue found in the pulp cavity of the tooth, containing blood vessels and nerves that provide nutrition and sensation to the tooth.

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Tooth Eruption

The process of teeth erupting through the gums and appearing in the mouth.

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Deciduous Teeth

The first set of teeth that develop in humans, also called baby teeth.

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Permanent Teeth

The permanent teeth that replace deciduous teeth during childhood.

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Nasal Placodes

Bilateral oval thickenings of the surface ectoderm, located on the inferolateral parts of the frontonasal prominence, that develop during the fourth week of embryonic development, forming the primordia of the nasal epithelium.

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Medial and Lateral Nasal Prominences

Horseshoe-shaped elevations formed by mesenchyme proliferation at the margins of the nasal placodes. They develop into the medial and lateral parts of the nose.

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Nasal Pits

Depressions formed by the stretching of the nasal placodes, where the nasal pits reside. They represent the early stages of the anterior nares (nostrils) and nasal cavities.

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Medial Nasal Prominence Movement

The process of the medial nasal prominences moving towards the midline, driven by the proliferation of the maxillary prominences. This movement is regulated by PDGFRA signaling.

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Nasolacrimal Groove

A groove that separates the lateral nasal prominence from the maxillary prominence. It plays a role in the development of the nasolacrimal duct.

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Auricular Hillocks

Six mesenchymal swellings that develop around the first pharyngeal groove during the fifth week, ultimately forming the external ear structure and external acoustic meatus.

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Maxillary-Lateral Nasal Prominence Fusion

The process of the maxillary prominence merging with the lateral nasal prominence along the line of the nasolacrimal groove. This establishes the continuity between the side of the nose and the cheek.

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Nasolacrimal Duct Development

A rod-like thickening of ectoderm in the floor of the nasolacrimal groove, which develops into the nasolacrimal duct, responsible for draining tears from the eyes to the nasal cavity.

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What is the palatal suture?

The line where the primary and secondary palates fused during embryonic development.

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How does the nasal septum form and fuse with the palate?

The nasal septum develops as a downward growth from the merged medial nasal prominences. It joins with the palatine processes starting anteriorly during the ninth week and continues posteriorly until the twelfth week, above the developing hard palate.

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What produces dentin in teeth?

Specialized cells called odontoblasts, which originate from neural crest cells, produce dentin, the hard tissue underlying enamel.

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What are ameloblasts and what do they produce?

A layer of epithelial cells called ameloblasts differentiates from the inner dental epithelium, forming enamel, the hard outer layer of teeth.

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What is the dental lamina and what does it form?

The inner dental epithelium forms a C-shaped structure called the dental lamina, which gives rise to dental buds, precursors of the teeth.

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Describe the dental cap and its components.

The dental cap, consisting of an outer dental epithelium, an inner dental epithelium, and a central stellate reticulum, forms during tooth development.

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What is the dental papilla and what does it become?

The dental papilla, derived from neural crest cells, is located within the indentation of the dental cap and is responsible for forming the pulp of the tooth.

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What happens to the dental cap during tooth development?

As the tooth develops, the dental cap takes on a bell shape, with mesenchyme cells differentiating into odontoblasts, which lay down dentin.

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Study Notes

Development of the Face

  • Facial primordia appear in the fourth week, around the stomodeum (mouth).
  • Facial development is influenced by the forebrain, frontonasal ectodermal zone, and developing eye.
  • Five facial primordia emerge: frontonasal (single), maxillary (paired), and mandibular (paired).
  • Maxillary and mandibular prominences are derivatives of the first pharyngeal arches.
  • Neural crest cells are the major source of connective tissues like cartilage, bone, and ligaments in the facial and oral regions.
  • The frontonasal prominence surrounds the ventrolateral forebrain, forming the forehead, and nasal part.
  • Maxillary prominences form the lateral boundaries of the stomodeum.
  • Mandibular prominences create the caudal boundary of the stomodeum.
  • Facial prominences act as growth centers, connecting through mesenchyme.
  • By the end of the fourth week, bilateral oval thickenings (nasal placodes) of surface ectoderm develop on the frontonasal prominence.
  • Nasal pits develop from the initially convex nasal placodes, which become depressed.
  • Nasal pits form the anterior nares (nostrils) and nasal cavities.
  • The lateral nasal prominences create the alae (sides) of the nose.
  • The medial nasal prominences merge to form the middle part of the upper lip (philtrum).

Development of the Palate

  • The palate develops from two primordia: primary and secondary palates.
  • Palatogenesis begins in the 6th week but isn't complete until the 12th week.
  • Molecular pathways like WNT and PRICKLE1 are involved in this process.
  • The critical palatogenesis period is from the end of the sixth week to the start of the ninth.
  • The primary palate (median process) develops early in the sixth week from merging medial nasal prominences.
  • It forms the anterior and midline aspect of the maxilla, specifically the premaxillary part.
  • The secondary palate, arising from two lateral palatine processes, develops in the sixth week.
  • These processes grow downwards, meet in the midline, and fuse.
  • The fusion process begins anteriorly in the ninth week and is completed superior to the hard palate primordium by the 12th week.
  • The fusion line is marked by the palatine raphe.
  • The posterior aspect of the palate does not ossify.
  • The primary palate forms the premaxillary part of the maxilla, which includes the incisor teeth.
  • The secondary palate creates the remaining hard and soft palate, including the uvula.
  • A nasopalatine canal persists in the median plane of the palate between the anterior maxilla.

Tooth Development

  • Tooth development begins in the sixth week.
  • The dental lamina (C-shaped structure) forms in the oral cavity along the jaws.
  • This lamina gives rise to dental buds.
  • Tooth development goes through stages: bud, cap, and bell stages.
  • Within the cap stage, an outer and inner dental layer and the stellate reticulum form.
  • Cells in the dental papilla differentiate into odontoblasts, forming dentin.
  • Odontoblasts retreat, leaving a layer.
  • Formation of the root of the tooth is marked by the penetration of the dental epithelial layers into the underlying mesenchyme.
  • Cells in the dental papilla form a layer of dentin.
  • Mesenchymal cells differentiate into cementoblasts, and they produce cementum.
  • Eruption of deciduous teeth occurs between 6 to 24 months after birth.
  • Permanent teeth erupt later, pushing out the deciduous ones.

Anomalies of Face Development

  • Nasolacrimal duct atresia: partial failure of the nasolacrimal duct to canalize.
  • Congenital auricular sinuses and cysts are usually triangular, located in the skin anterior to the auricle.
  • Cleft lip (either unilateral or bilateral): failure of the maxillary and medial nasal prominences to fuse.
  • Cleft palate: failure of the palatine processes to fuse. It can be further categorized as anterior or posterior, complete or incomplete.
  • The different types result from failure of mesenchymal masses in the appropriate areas.
  • Congenital microstomia: a small mouth due to excessive merging of the maxillary and mandibular prominences.
  • Common causes include both genetic and environmental factors, including multifactorial, chromosomal, genetic factors.

Postnatal Development of Paranasal Sinuses

  • Most paranasal sinuses are rudimentary or absent at birth.
  • Maxillary sinuses are small at birth and grow slowly until puberty, completing development with the eruption of permanent teeth.
  • Frontal and sphenoidal sinuses are not present at birth and grow after the age of 2 years.
  • The growth of these structures changes the shape of the face during infancy and adolescence and adds to vocal resonance.

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