Dermatology Quiz: Connective Tissue Disorders and Treatment
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Questions and Answers

What is the most associated cancer with the sudden waxy brown papules on the trunk in a 65-year-old female?

  • Liver
  • Stomach
  • Lung (correct)
  • Pancreas
  • In a female patient with a brown macular rash on the cubital fossa, what is the best treatment?

  • Phototherapy
  • Topical steroid (correct)
  • Cyclosporine
  • Antibiotic
  • Which medication is the most appropriate for treating erythema, edema, induration of the whole face, and stiffness of both lower limbs, along with periungual erythema in a patient?

  • Steroids
  • Sildenafil
  • Colchicine (correct)
  • Pentoxyphylline
  • In a 10-year-old child with linear morhea, what treatment should be combined with steroids?

    <p>MTX</p> Signup and view all the answers

    What treatment is appropriate for eruptive skin-colored papules with hardness on the face and upper back?

    <p>Thalidomide</p> Signup and view all the answers

    What is the prophylactic treatment for photosensitivity in connective tissue disease?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    In the case of granuloma with few lymphocytes and erythematous plaque in a patient with sarcoidosis, which biologic treatment would be most appropriate?

    <p>Rituximab</p> Signup and view all the answers

    In a patient with dermatomyositis controlled on prednisolone and methotrexate (MTX) intake, who develops myopathy after one week, what would be the next appropriate step?

    <p>Decrease steroid</p> Signup and view all the answers

    In a patient presenting with sclerodactyly, Raynaud's phenomenon, and photosensitivity, which investigation would be most relevant for diagnosing mixed connective tissue disease?

    <p>U1RNP</p> Signup and view all the answers

    In familial systemic lupus erythematosus (SLE), which complement deficiency is associated with the condition?

    <p>5</p> Signup and view all the answers

    In a patient presenting with Gottron rash on both hands and rash on the ear, what would be the most appropriate treatment?

    <p>Dapsone</p> Signup and view all the answers

    What is the most suitable treatment for a patient with acquired digital fibrokeratoma?

    <p>Surgical removal</p> Signup and view all the answers

    In a case of dermatomyositis controlled on prednisolone and methotrexate (MTX) intake started for one week of myopathy, what is the next step?

    <p>Decrease steroid</p> Signup and view all the answers

    In a case of a girl with an itchy hyperpigmented patch on the trunk with histopathology showing amyloidosis, which specialist should be referred to?

    <p>Endocrinologist</p> Signup and view all the answers

    What is the most appropriate investigation needed in a case of discoid lupus with follicular plugging?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    In a case of hypertrophic discoid lupus erythematosus (DLE) with interface dermatitis and thickening basement membrane, what would be an important investigation to consider?

    <p>HIV testing</p> Signup and view all the answers

    A patient presents with asymptomatic maculopapular lesions on the left arm. What would be the appropriate approach to treatment?

    <p>Initiate symptomatic treatment</p> Signup and view all the answers

    What would be the most suitable treatment for a female with genital plaque and asymptomatic lichen sclerosis?

    <p>Steroid therapy</p> Signup and view all the answers

    A patient presents with erythematous plaque on the nose with associated pustules. What would be the appropriate treatment and diagnosis?

    <p>Minocycline</p> Signup and view all the answers

    In a case of pseudoxanthoma elasticum, what is considered as a protective treatment?

    <p>Aspirin or cessation of smoking</p> Signup and view all the answers

    What is the expected complication in pseudoxanthoma elasticum?

    <p>Peripheral arterial disease</p> Signup and view all the answers

    In a patient with cutis laxa presenting with mutation, periorbital edema, and sagged cheeks, what should be considered as an appropriate investigative option?

    <p>Blood glucose testing</p> Signup and view all the answers

    A patient presents with Reynaud's phenomenon, edematous fingers, and low C3 and C4 levels. What would be the best treatment option?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    What is the prophylactic treatment for photosensitivity in connective tissue disease?

    <p>Carotene</p> Signup and view all the answers

    In a case of granuloma with few lymphocytes and erythematous plaque in a patient with sarcoidosis, which biologic treatment would be most appropriate?

    <p>Infliximab</p> Signup and view all the answers

    In a patient with dermatomyositis controlled on prednisolone and methotrexate (MTX) intake started for one week of myopathy, what is the next appropriate step?

    <p>Increase steroid</p> Signup and view all the answers

    In a patient presenting with sclerodactyly, Raynaud's phenomenon, and photosensitivity, which investigation would be most relevant for diagnosing mixed connective tissue disease?

    <p>U1RNP</p> Signup and view all the answers

    In familial systemic lupus erythematosus (SLE), which complement deficiency is associated with the condition?

    <p>5</p> Signup and view all the answers

    In a case of small ulcer on digit, photosensitivity, fibrosis, pigmentation, which investigation would be most appropriate?

    <p>Double strand DNA</p> Signup and view all the answers

    In a picture of calcinosis cutis in the thigh in a renal patient, which investigation would be most appropriate?

    <p>X-ray</p> Signup and view all the answers

    In a patient with photosensitivity, which investigation would be most appropriate?

    <p>ANA</p> Signup and view all the answers

    What is the most associated cancer with the sudden waxy brown papules on the trunk in a 65-year-old female?

    <p>Breast cancer</p> Signup and view all the answers

    In a patient presenting with Gottron rash on both hands and rash on the ear, what would be the most appropriate treatment?

    <p>Dapsone</p> Signup and view all the answers

    In a case of JXG association (Juvenile xantho-granuloma), what investigation would confirm the diagnosis?

    <p>CD68 staining</p> Signup and view all the answers

    What is the most appropriate treatment for a patient with lichen sclerosus et atrophicus?

    <p>Surgical removal</p> Signup and view all the answers

    In a patient with amyloidosis indicated by histopathology, which specialist should they be referred to?

    <p>Nephrologist</p> Signup and view all the answers

    In a case of lichen sclerosus et atrophicus, what is the next step of management?

    <p>Topical steroid (clobetasol)</p> Signup and view all the answers

    What is the most appropriate treatment for a patient with discoid lupus and persistent scarring for 3 years?

    <p>Camouflage</p> Signup and view all the answers

    In a patient with asymptomatic maculopapular lesions on the left arm, what would be the appropriate approach to treatment?

    <p>Symptomatic management</p> Signup and view all the answers

    What investigation would be most relevant for diagnosing mixed connective tissue disease in a patient presenting with sclerodactyly, Raynaud's phenomenon, and photosensitivity?

    <p>Anti-RNP</p> Signup and view all the answers

    What is the best treatment option for a child with Encopé de Sabre?

    <p>Subcutaneous MTX</p> Signup and view all the answers

    What is the most associated cancer with sudden waxy brown papules on the trunk in a 65-year-old female?

    <p>Liver</p> Signup and view all the answers

    What is the best treatment for a female patient with brown macular rash on the cubital fossa?

    <p>Topical steroid</p> Signup and view all the answers

    Which medication is the most appropriate for treating erythema, edema, induration of the whole face, and stiffness of both lower limbs, along with periungual erythema in a patient?

    <p>Steroids</p> Signup and view all the answers

    What treatment will you combine with steroids for linear morphea in a 10-year-old child?

    <p>MTX</p> Signup and view all the answers

    What is considered as a protective treatment in a case of pseudoxanthoma elasticum?

    <p>NBUVB</p> Signup and view all the answers

    What investigation would be most relevant for diagnosing mixed connective tissue disease in a patient presenting with sclerodactyly, Raynaud's phenomenon, and photosensitivity?

    <p>ANA</p> Signup and view all the answers

    What would be an important investigation to consider in a case of hypertrophic discoid lupus erythematosus (DLE) with interface dermatitis and thickening basement membrane?

    <p>Skin biopsy then DIF then ANA</p> Signup and view all the answers

    What is the most common site for that disease?

    <p>Face</p> Signup and view all the answers

    What is the most associated cancer with sudden waxy brown papules on the trunk in a 65-year-old female?

    <p>Stomach</p> Signup and view all the answers

    In a female patient with brown macular rash on the cubital fossa, what is the best treatment?

    <p>Topical steroid</p> Signup and view all the answers

    What is the best treatment for eruptive skin-colored papules with hardness on the face and upper back?

    <p>Biologic Rituximab</p> Signup and view all the answers

    In a patient with atrophic lesions and telangiectasia on the surface, which investigation would be most appropriate?

    <p>Skin biopsy then DIF then ANA</p> Signup and view all the answers

    What is the most common site for that disease?

    <p>Trunk</p> Signup and view all the answers

    Which manifestation is not associated with subacute LE?

    <p>Scarring</p> Signup and view all the answers

    What is the prophylactic treatment for photosensitivity in connective tissue disease?

    <p>Carotene</p> Signup and view all the answers

    In a case of granuloma with few lymphocytes and erythematous plaque in a patient with sarcoidosis, which biologic treatment would be most appropriate?

    <p>Infliximab</p> Signup and view all the answers

    In familial systemic lupus erythematosus (SLE), which complement deficiency is associated with the condition?

    <p>5</p> Signup and view all the answers

    What investigation would be most relevant for diagnosing mixed connective tissue disease in a patient presenting with sclerodactyly, Raynaud's phenomenon, and photosensitivity?

    <p>U1RNP</p> Signup and view all the answers

    What is the type of light chain in systemic amyloidosis?

    <p>Lambda</p> Signup and view all the answers

    In a case of small ulcer on digit, photosensitivity, fibrosis, pigmentation, which investigation would be most appropriate?

    <p>ANA</p> Signup and view all the answers

    What specialist should be referred to for a girl with an itchy hyperpigmented patch on the trunk and histopathology showing amyloidosis?

    <p>Endocrinologist</p> Signup and view all the answers

    In a patient with discoid lupus exhibiting persistent scarring for 3 years, what would be the most appropriate treatment?

    <p>No treatment</p> Signup and view all the answers

    In a patient with asymptomatic maculopapular lesions on the left arm, what would be the appropriate approach to treatment?

    <p>Symptomatic treatment</p> Signup and view all the answers

    What is the most suitable treatment for a female with genital plaque and asymptomatic lichen sclerosis?

    <p>Surgical removal</p> Signup and view all the answers

    In a case of lichen sclerosus et atrophicus, what would be the next step of management?

    <p>Add acitretin</p> Signup and view all the answers

    Study Notes

    Skin Conditions and Treatments

    • Sudden waxy brown papules on the trunk in a 65-year-old female are most associated with sebaceous gland carcinoma.
    • Brown macular rash on the cubital fossa in a female patient is best treated with topical steroids.
    • Erythema, edema, induration of the whole face, and stiffness of both lower limbs, along with periungual erythema in a patient, is best treated with systemic steroids.

    Dermatological Conditions

    • Linear morphea in a 10-year-old child is best treated with steroids and physiotherapy.
    • Eruptive skin-colored papules with hardness on the face and upper back are best treated with isotretinoin.
    • Photosensitivity in connective tissue disease is best treated with hydroxychloroquine.

    Autoimmune Disorders

    • Sarcoidosis with granuloma and few lymphocytes is best treated with biologic medications.
    • Dermatomyositis controlled on prednisolone and methotrexate (MTX) intake, with myopathy after one week, requires invasive electromyography as the next step.
    • Mixed connective tissue disease is diagnosed with anti-U1 RNP antibody.

    Rare Skin Conditions

    • Familial systemic lupus erythematosus (SLE) is associated with complement deficiency.
    • Gottron rash on both hands and rash on the ear is best treated with systemic steroids.
    • Acquired digital fibrokeratoma is best treated with surgical excision.

    Miscellaneous

    • In a case of amyloidosis, the patient should be referred to a hematologist.
    • In a case of discoid lupus, the most relevant investigation is histopathology.
    • In a case of hypertrophic discoid lupus erythematosus (DLE) with interface dermatitis and thickening basement membrane, the most relevant investigation is immunofluorescence.
    • Pseudoxanthoma elasticum is considered a protective treatment.
    • The expected complication in pseudoxanthoma elasticum is blindness.
    • Cutis laxa is diagnosed with genetic testing.

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    Description

    Test your knowledge of dermatology with this quiz on connective tissue disorders, photosensitivity, granuloma, lymphocytes, and treatment options including steroids, biologics, and prophylactic measures. Evaluate your understanding of patient management and treatment decisions.

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