Dengue Fever Overview
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Questions and Answers

What is the primary cause of dengue fever?

Dengue fever is primarily caused by any one of four closely related dengue viruses transmitted through the bite of an infected aedes mosquito.

List three common symptoms of dengue fever.

Common symptoms of dengue fever include high fever, headache, and joint pain.

How does a mosquito become infected with the dengue virus?

A mosquito becomes infected by biting a person who has dengue virus in their blood.

Why can dengue fever not be transmitted directly from person to person?

<p>Dengue fever is transmitted exclusively through mosquito bites, not through direct person-to-person contact.</p> Signup and view all the answers

What types of tests can help diagnose dengue fever?

<p>Dengue fever can be diagnosed using serologic tests, molecular tests, and complete blood count (CBC).</p> Signup and view all the answers

What is the significance of the MAC-ELISA test in diagnosing dengue fever?

<p>The MAC-ELISA test detects antibodies produced by the immune system specifically against the dengue virus.</p> Signup and view all the answers

Describe the role of complete blood count (CBC) in assessing dengue fever severity.

<p>A complete blood count (CBC) helps predict the severity of dengue fever by checking for drops in white blood cells and platelets.</p> Signup and view all the answers

In which regions of the world are dengue fever cases most commonly reported?

<p>Dengue fever is most commonly reported in tropical areas such as Southeast Asia, Latin America, and Africa.</p> Signup and view all the answers

What is the primary difference between the Dengvaxia and Qdenga vaccines in terms of previous infection status?

<p>Dengvaxia is recommended for those who have previously had dengue fever, while Qdenga is for individuals who have not been infected.</p> Signup and view all the answers

How many doses are required for the Dengvaxia vaccine, and at what intervals are they administered?

<p>Dengvaxia requires three doses, administered at six-month intervals.</p> Signup and view all the answers

What age group is Dengvaxia typically recommended for?

<p>Dengvaxia is recommended for individuals aged 6 to 45, with some countries extending approval to ages 9 to 60.</p> Signup and view all the answers

List two personal protective measures one can take to avoid dengue mosquito bites.

<p>Wearing protective clothing and using mosquito repellents are two effective measures.</p> Signup and view all the answers

What specific symptom detection is critical for better outcomes in dengue treatment?

<p>Early detection of severe symptoms is critical for better treatment outcomes.</p> Signup and view all the answers

What type of medications should be avoided if someone contracts dengue fever?

<p>Non-steroidal anti-inflammatory drugs, such as ibuprofen and aspirin, should be avoided.</p> Signup and view all the answers

In what year was the Dengvaxia vaccine licensed by the U.S. Food and Drug Administration?

<p>Dengvaxia was licensed by the U.S. FDA in 1997.</p> Signup and view all the answers

What is one method for preventing mosquito breeding mentioned in the content?

<p>Covering, emptying, and cleaning domestic water storage containers weekly is one method.</p> Signup and view all the answers

Study Notes

Dengue Fever Overview

  • Dengue fever is a mosquito-borne viral disease, caused by four related viruses.
  • Transmission occurs through the bite of an Aedes mosquito infected with a dengue virus.
  • Mosquitoes become infected by biting humans with the virus in their blood.
  • Direct human-to-human transmission does not occur.
  • Approximately 400 million people globally are infected annually, with 100 million experiencing mild to severe illness.
  • Predominantly prevalent in tropical areas including Southeast Asia, the western Pacific, Latin America, and Africa.
  • Cases in the U.S. are typically associated with travel-acquired infections, with increasing risk in Southern regions.

Symptoms

  • High fever
  • Severe headaches
  • Pain behind the eyes
  • Joint and muscle pain
  • Nausea
  • Vomiting
  • Skin rash

Transmission Cycle

  • Infected mosquitoes bite humans, becoming infected.
  • Infected mosquitoes then bite other people, spreading the virus.
  • This cycle perpetuates transmission within communities.

Diagnosis

  • Diagnosis is made through blood tests.
  • Blood samples are analyzed for signs of the dengue virus, potentially using:
    • Serologic/antibody tests
    • MAC-ELISA test
    • Molecular tests (e.g., NAATs, PCR)
    • Complete blood count (CBC): checks for reduced white blood cells and platelets

Dengue Vaccines

  • Dengue vaccines have been under development since the 1920s.
  • Dengvaxia is a licensed vaccine and the only one approved by U.S. FDA, recommended for those with prior dengue infection or living in high risk areas (aged 6-45).
  • Qdenga is a second vaccine, approved in the EU in 2022. Qdenga is for individuals who haven't previously had dengue (aged 4 or older).

Prevention and Control

  • Mosquitoes are active during the day.
  • Prevent mosquito bites by:
    • Wearing protective clothing
    • Using mosquito nets (especially treated ones)
    • Employing window screens
    • Applying insect repellents (DEET, Picaridin, IR3535)
    • Utilizing coils and vaporizers
  • Prevent mosquito breeding by:
    • Managing/modifying egg-laying environments
    • Properly disposing of waste (including artificial containers)
    • Regularly covering, emptying, and cleaning water storage containers
    • Using insecticides on outdoor water sources
  • If infected with dengue:
    • Rest adequately
    • Drink plenty of fluids
    • Use acetaminophen (paracetamol) for pain relief
    • Avoid non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin
    • Monitor for severe symptoms and promptly consult a healthcare professional

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Description

This quiz provides an overview of dengue fever, a mosquito-borne viral disease caused by four related viruses. Learn about its transmission cycle, symptoms, and global prevalence, particularly in tropical areas. Test your knowledge of how this disease spreads and affects populations.

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