Dengue Fever Clinical Manifestations and Complications
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Questions and Answers

What percentage of cases exhibit joint pain as a clinical manifestation?

  • 92% (correct)
  • 95%
  • 85%
  • 80%

    • What is the common name of the virus that causes dengue fever?

  • Flavivirus (correct)
  • Arbovirus
  • Yellow fever virus
  • Denguevirus

    • What is a complication of dengue fever in pregnant women?

  • Splenomegaly
  • Osteomyelitis
  • Anemia
  • Infection of the developing fetus (correct)

    • What is the duration of recovery from dengue fever?

    <p>1 week</p> Signup and view all the answers

    What is the vector responsible for transmitting dengue fever?

    <p>Aedes aegypti and Aedes albopictus mosquitoes</p> Signup and view all the answers

    What is the consequence of removing stagnant water?

    <p>Preventing mosquito breeding</p> Signup and view all the answers

    What is the consequence of infection with dengue fever?

    <p>Immunity to future infections</p> Signup and view all the answers

    What is the name of the family of viruses that includes dengue fever?

    <p>Flaviviridae</p> Signup and view all the answers

    What is a common complication of dengue fever?

    <p>All of the above</p> Signup and view all the answers

    What is the type of virus that causes dengue fever?

    <p>RNA virus</p> Signup and view all the answers

    What is the primary site of viral multiplication in a susceptible vertebrate host?

    <p>Myeloid and lymphoid cells, and vascular endothelium</p> Signup and view all the answers

    What is the role of type 1 interferon (IFN) in CHKV infection?

    <p>Production via activation of non-hematopoietic cells</p> Signup and view all the answers

    What is the function of the E1 protein in CHKV?

    <p>Viral fusion</p> Signup and view all the answers

    What is the common route of transmission of CHKV?

    <p>Vector-borne transmission through infected mosquitoes</p> Signup and view all the answers

    What is the size of the CHKV genome?

    <p>11-12 kb</p> Signup and view all the answers

    What is the morphology of CHKV?

    <p>Spherical, 70 nm in diameter</p> Signup and view all the answers

    What is the role of monocyte-derived macrophages in CHKV infection?

    <p>Viral tropism</p> Signup and view all the answers

    What is the incubation period of CHKV?

    <p>2-4 days</p> Signup and view all the answers

    What is the outcome of CHKV infection in some cases?

    <p>Severe arthritis and joint pain</p> Signup and view all the answers

    What is the route of transmission in the laboratory setting?

    <p>Aerosol exposure</p> Signup and view all the answers

    What is the primary reservoir for the transmission of Dengue virus?

    <p>Humans</p> Signup and view all the answers

    What is the incubation period of Dengue virus?

    <p>3-14 days</p> Signup and view all the answers

    What is the purpose of collecting two serum samples for diagnosis?

    <p>To identify whether the patient has developed antibodies against the virus</p> Signup and view all the answers

    What is the role of infected cells in the pathogenesis of Dengue virus?

    <p>They produce signaling proteins</p> Signup and view all the answers

    What is the diagnostic method used to detect virus-specific IgM in serum or CSF?

    <p>All of the above</p> Signup and view all the answers

    What is the size of the Dengue virus genome?

    <p>11 kb</p> Signup and view all the answers

    What is the result of viral replication in the cells of the mononuclear phagocyte lineage?

    <p>Viremia develops within 24 hours</p> Signup and view all the answers

    What is the significance of cross-reactivity in making a diagnosis?

    <p>It should be considered due to the presence of antibodies to other members of the flavivirus group</p> Signup and view all the answers

    What is the purpose of polymerase chain reaction (PCR) assays in laboratory diagnosis?

    <p>To detect the presence of viral genome</p> Signup and view all the answers

    What is the result of a high viral load in severe cases of Dengue virus infection?

    <p>Many vital organs are affected</p> Signup and view all the answers

    Which of the following congenital anomalies may occur in a fetus when a pregnant woman is infected with dengue virus?

    <p>Multiple congenital anomalies</p> Signup and view all the answers

    In which trimester of pregnancy does dengue virus infection pose the greatest risk to the fetus?

    <p>Later in pregnancy</p> Signup and view all the answers

    What is a possible outcome of dengue fever infection in people above 65 years old?

    <p>Increased severity of symptoms</p> Signup and view all the answers

    What is the benefit of removing stagnant water from the environment?

    <p>Prevents mosquito breeding</p> Signup and view all the answers

    What is the duration of immunity to dengue fever virus after infection?

    <p>Lifetime immunity</p> Signup and view all the answers

    What is the family of viruses that includes dengue fever?

    <p>Flaviviridae</p> Signup and view all the answers

    What is a characteristic clinical manifestation of dengue fever?

    <p>Joint pain</p> Signup and view all the answers

    What is the consequence of dengue fever infection in people with underlying conditions?

    <p>Increased risk of complications</p> Signup and view all the answers

    What is the incubation period of dengue fever?

    <p>Recovery: 1 week, but may persist</p> Signup and view all the answers

    Which of the following is NOT a complication of dengue fever?

    <p>Meningitis</p> Signup and view all the answers

    What is the primary site of viral replication in the host after the initial infection?

    <p>Skin</p> Signup and view all the answers

    What is the role of E2 protein in CHKV?

    <p>Mediates cell attachment</p> Signup and view all the answers

    What is the outcome of CHKV infection in some cases?

    <p>Severe joint pain</p> Signup and view all the answers

    What is the mechanism by which CHKV triggers an innate immune response?

    <p>Activation of type 1 interferon (IFN)</p> Signup and view all the answers

    What is the primary mode of transmission of CHKV in the urban cycle?

    <p>Vector-borne transmission</p> Signup and view all the answers

    What is the significance of the blood-brain barrier in CHKV infection?

    <p>Prevents viral replication in the CNS</p> Signup and view all the answers

    What is the characteristic of the nucleocapsid of CHKV?

    <p>Spherical structure with 42 capsomeres</p> Signup and view all the answers

    What is the primary role of fibroblasts in CHKV infection?

    <p>Viral replication</p> Signup and view all the answers

    What is the significance of the sylvatic cycle in CHKV transmission?

    <p>Transmission from animal to human</p> Signup and view all the answers

    What is the type of RNA present in the CHKV genome?

    <p>Positive-sense RNA</p> Signup and view all the answers

    What is the primary mechanism by which Dengue virus is transmitted?

    <p>Through a bite of an infected female Aedes mosquito</p> Signup and view all the answers

    What is the role of infected macrophages in Dengue virus infection?

    <p>To produce signaling proteins: Interferons, Cytokines, Chemokines, TNF</p> Signup and view all the answers

    What is the significance of collecting two serum samples for diagnosis?

    <p>To identify whether the patient has antibodies against the causative agent</p> Signup and view all the answers

    What is the characteristic of the Dengue virus genome?

    <p>Positive-sense, single stranded RNA</p> Signup and view all the answers

    What is the primary reservoir of Dengue virus transmission?

    <p>Humans</p> Signup and view all the answers

    What is the method used to detect virus-specific IgM in serum or CSF?

    <p>IgM-capture ELISA</p> Signup and view all the answers

    What is the consequence of a high viral load in severe cases of Dengue virus infection?

    <p>A very high viral load affecting many vital organs</p> Signup and view all the answers

    What is the role of type 1 interferon (IFN) in Dengue virus infection?

    <p>To inhibit viral replication</p> Signup and view all the answers

    What is the morphology of Dengue virus?

    <p>Spherical, 40-60 nm in diameter</p> Signup and view all the answers

    What is the significance of cross-reactivity in making a diagnosis?

    <p>It indicates the presence of antibodies against other members of the flavivirus group</p> Signup and view all the answers

    The incubation period of dengue fever is typically less than 1 week.

    <p>False</p> Signup and view all the answers

    Dengue fever can only be transmitted through the bite of an infected Aedes albopictus mosquito.

    <p>False</p> Signup and view all the answers

    Infection with dengue fever provides lifelong immunity against subsequent infections.

    <p>True</p> Signup and view all the answers

    The primary site of viral replication in the host after the initial infection is the liver.

    <p>False</p> Signup and view all the answers

    Dengue fever can cause congenital anomalies in the fetus if the mother is infected during the first trimester of pregnancy.

    <p>True</p> Signup and view all the answers

    Removing stagnant water from the environment can prevent the transmission of dengue fever.

    <p>True</p> Signup and view all the answers

    Louis encephalitis is a congenital disease that can be caused by intrauterine infection during the first trimester.

    <p>True</p> Signup and view all the answers

    Dengue virus has a negative-sense, single-stranded RNA genome.

    <p>False</p> Signup and view all the answers

    Aedes albopictus is a minor vector of Dengue virus transmission.

    <p>False</p> Signup and view all the answers

    Viral replication in the cells of the mononuclear phagocyte lineage leads to the production of interferons and cytokines.

    <p>True</p> Signup and view all the answers

    The diagnosis of Dengue virus infection is confirmed by detecting virus-specific IgG antibodies in serum or CSF.

    <p>False</p> Signup and view all the answers

    Dengue virus infection is treatable with a vaccine.

    <p>False</p> Signup and view all the answers

    The incubation period of CHKV is 1-2 weeks.

    <p>False</p> Signup and view all the answers

    CHKV is classified in the virus family Flaviviridae.

    <p>False</p> Signup and view all the answers

    The primary site of viral multiplication in a susceptible vertebrate host is the liver.

    <p>False</p> Signup and view all the answers

    Type 1 interferon (IFN) is produced via activation of hematopoietic cells.

    <p>False</p> Signup and view all the answers

    The urban cycle of CHKV transmission involves transmission from an animal to a mosquito to a human.

    <p>False</p> Signup and view all the answers

    The genome of CHKV is double-stranded DNA.

    <p>False</p> Signup and view all the answers

    CHKV is primarily transmitted through the bite of an infected tick.

    <p>False</p> Signup and view all the answers

    CHKV infection can be diagnosed through the detection of virus-specific IgG in serum or CSF.

    <p>False</p> Signup and view all the answers

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