Dengue Fever Clinical Manifestations and Complications

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Questions and Answers

What percentage of cases exhibit joint pain as a clinical manifestation?

  • 92% (correct)
  • 95%
  • 85%
  • 80%

What is the common name of the virus that causes dengue fever?

  • Flavivirus (correct)
  • Arbovirus
  • Yellow fever virus
  • Denguevirus

What is a complication of dengue fever in pregnant women?

  • Splenomegaly
  • Osteomyelitis
  • Anemia
  • Infection of the developing fetus (correct)

What is the duration of recovery from dengue fever?

<p>1 week (C)</p> Signup and view all the answers

What is the vector responsible for transmitting dengue fever?

<p>Aedes aegypti and Aedes albopictus mosquitoes (B)</p> Signup and view all the answers

What is the consequence of removing stagnant water?

<p>Preventing mosquito breeding (A)</p> Signup and view all the answers

What is the consequence of infection with dengue fever?

<p>Immunity to future infections (A)</p> Signup and view all the answers

What is the name of the family of viruses that includes dengue fever?

<p>Flaviviridae (A)</p> Signup and view all the answers

What is a common complication of dengue fever?

<p>All of the above (D)</p> Signup and view all the answers

What is the type of virus that causes dengue fever?

<p>RNA virus (A)</p> Signup and view all the answers

What is the primary site of viral multiplication in a susceptible vertebrate host?

<p>Myeloid and lymphoid cells, and vascular endothelium (B)</p> Signup and view all the answers

What is the role of type 1 interferon (IFN) in CHKV infection?

<p>Production via activation of non-hematopoietic cells (B)</p> Signup and view all the answers

What is the function of the E1 protein in CHKV?

<p>Viral fusion (C)</p> Signup and view all the answers

What is the common route of transmission of CHKV?

<p>Vector-borne transmission through infected mosquitoes (A)</p> Signup and view all the answers

What is the size of the CHKV genome?

<p>11-12 kb (C)</p> Signup and view all the answers

What is the morphology of CHKV?

<p>Spherical, 70 nm in diameter (A)</p> Signup and view all the answers

What is the role of monocyte-derived macrophages in CHKV infection?

<p>Viral tropism (D)</p> Signup and view all the answers

What is the incubation period of CHKV?

<p>2-4 days (A)</p> Signup and view all the answers

What is the outcome of CHKV infection in some cases?

<p>Severe arthritis and joint pain (D)</p> Signup and view all the answers

What is the route of transmission in the laboratory setting?

<p>Aerosol exposure (B)</p> Signup and view all the answers

What is the primary reservoir for the transmission of Dengue virus?

<p>Humans (A)</p> Signup and view all the answers

What is the incubation period of Dengue virus?

<p>3-14 days (B)</p> Signup and view all the answers

What is the purpose of collecting two serum samples for diagnosis?

<p>To identify whether the patient has developed antibodies against the virus (A)</p> Signup and view all the answers

What is the role of infected cells in the pathogenesis of Dengue virus?

<p>They produce signaling proteins (C)</p> Signup and view all the answers

What is the diagnostic method used to detect virus-specific IgM in serum or CSF?

<p>All of the above (D)</p> Signup and view all the answers

What is the size of the Dengue virus genome?

<p>11 kb (B)</p> Signup and view all the answers

What is the result of viral replication in the cells of the mononuclear phagocyte lineage?

<p>Viremia develops within 24 hours (A)</p> Signup and view all the answers

What is the significance of cross-reactivity in making a diagnosis?

<p>It should be considered due to the presence of antibodies to other members of the flavivirus group (B)</p> Signup and view all the answers

What is the purpose of polymerase chain reaction (PCR) assays in laboratory diagnosis?

<p>To detect the presence of viral genome (A)</p> Signup and view all the answers

What is the result of a high viral load in severe cases of Dengue virus infection?

<p>Many vital organs are affected (B)</p> Signup and view all the answers

Which of the following congenital anomalies may occur in a fetus when a pregnant woman is infected with dengue virus?

<p>Multiple congenital anomalies (C)</p> Signup and view all the answers

In which trimester of pregnancy does dengue virus infection pose the greatest risk to the fetus?

<p>Later in pregnancy (C)</p> Signup and view all the answers

What is a possible outcome of dengue fever infection in people above 65 years old?

<p>Increased severity of symptoms (D)</p> Signup and view all the answers

What is the benefit of removing stagnant water from the environment?

<p>Prevents mosquito breeding (C)</p> Signup and view all the answers

What is the duration of immunity to dengue fever virus after infection?

<p>Lifetime immunity (D)</p> Signup and view all the answers

What is the family of viruses that includes dengue fever?

<p>Flaviviridae (C)</p> Signup and view all the answers

What is a characteristic clinical manifestation of dengue fever?

<p>Joint pain (C)</p> Signup and view all the answers

What is the consequence of dengue fever infection in people with underlying conditions?

<p>Increased risk of complications (B)</p> Signup and view all the answers

What is the incubation period of dengue fever?

<p>Recovery: 1 week, but may persist (A)</p> Signup and view all the answers

Which of the following is NOT a complication of dengue fever?

<p>Meningitis (D)</p> Signup and view all the answers

What is the primary site of viral replication in the host after the initial infection?

<p>Skin (D)</p> Signup and view all the answers

What is the role of E2 protein in CHKV?

<p>Mediates cell attachment (D)</p> Signup and view all the answers

What is the outcome of CHKV infection in some cases?

<p>Severe joint pain (B)</p> Signup and view all the answers

What is the mechanism by which CHKV triggers an innate immune response?

<p>Activation of type 1 interferon (IFN) (C)</p> Signup and view all the answers

What is the primary mode of transmission of CHKV in the urban cycle?

<p>Vector-borne transmission (D)</p> Signup and view all the answers

What is the significance of the blood-brain barrier in CHKV infection?

<p>Prevents viral replication in the CNS (C)</p> Signup and view all the answers

What is the characteristic of the nucleocapsid of CHKV?

<p>Spherical structure with 42 capsomeres (D)</p> Signup and view all the answers

What is the primary role of fibroblasts in CHKV infection?

<p>Viral replication (D)</p> Signup and view all the answers

What is the significance of the sylvatic cycle in CHKV transmission?

<p>Transmission from animal to human (D)</p> Signup and view all the answers

What is the type of RNA present in the CHKV genome?

<p>Positive-sense RNA (C)</p> Signup and view all the answers

What is the primary mechanism by which Dengue virus is transmitted?

<p>Through a bite of an infected female Aedes mosquito (D)</p> Signup and view all the answers

What is the role of infected macrophages in Dengue virus infection?

<p>To produce signaling proteins: Interferons, Cytokines, Chemokines, TNF (C)</p> Signup and view all the answers

What is the significance of collecting two serum samples for diagnosis?

<p>To identify whether the patient has antibodies against the causative agent (A)</p> Signup and view all the answers

What is the characteristic of the Dengue virus genome?

<p>Positive-sense, single stranded RNA (C)</p> Signup and view all the answers

What is the primary reservoir of Dengue virus transmission?

<p>Humans (D)</p> Signup and view all the answers

What is the method used to detect virus-specific IgM in serum or CSF?

<p>IgM-capture ELISA (B)</p> Signup and view all the answers

What is the consequence of a high viral load in severe cases of Dengue virus infection?

<p>A very high viral load affecting many vital organs (C)</p> Signup and view all the answers

What is the role of type 1 interferon (IFN) in Dengue virus infection?

<p>To inhibit viral replication (B)</p> Signup and view all the answers

What is the morphology of Dengue virus?

<p>Spherical, 40-60 nm in diameter (C)</p> Signup and view all the answers

What is the significance of cross-reactivity in making a diagnosis?

<p>It indicates the presence of antibodies against other members of the flavivirus group (A)</p> Signup and view all the answers

The incubation period of dengue fever is typically less than 1 week.

<p>False (B)</p> Signup and view all the answers

Dengue fever can only be transmitted through the bite of an infected Aedes albopictus mosquito.

<p>False (B)</p> Signup and view all the answers

Infection with dengue fever provides lifelong immunity against subsequent infections.

<p>True (A)</p> Signup and view all the answers

The primary site of viral replication in the host after the initial infection is the liver.

<p>False (B)</p> Signup and view all the answers

Dengue fever can cause congenital anomalies in the fetus if the mother is infected during the first trimester of pregnancy.

<p>True (A)</p> Signup and view all the answers

Removing stagnant water from the environment can prevent the transmission of dengue fever.

<p>True (A)</p> Signup and view all the answers

Louis encephalitis is a congenital disease that can be caused by intrauterine infection during the first trimester.

<p>True (A)</p> Signup and view all the answers

Dengue virus has a negative-sense, single-stranded RNA genome.

<p>False (B)</p> Signup and view all the answers

Aedes albopictus is a minor vector of Dengue virus transmission.

<p>False (B)</p> Signup and view all the answers

Viral replication in the cells of the mononuclear phagocyte lineage leads to the production of interferons and cytokines.

<p>True (A)</p> Signup and view all the answers

The diagnosis of Dengue virus infection is confirmed by detecting virus-specific IgG antibodies in serum or CSF.

<p>False (B)</p> Signup and view all the answers

Dengue virus infection is treatable with a vaccine.

<p>False (B)</p> Signup and view all the answers

The incubation period of CHKV is 1-2 weeks.

<p>False (B)</p> Signup and view all the answers

CHKV is classified in the virus family Flaviviridae.

<p>False (B)</p> Signup and view all the answers

The primary site of viral multiplication in a susceptible vertebrate host is the liver.

<p>False (B)</p> Signup and view all the answers

Type 1 interferon (IFN) is produced via activation of hematopoietic cells.

<p>False (B)</p> Signup and view all the answers

The urban cycle of CHKV transmission involves transmission from an animal to a mosquito to a human.

<p>False (B)</p> Signup and view all the answers

The genome of CHKV is double-stranded DNA.

<p>False (B)</p> Signup and view all the answers

CHKV is primarily transmitted through the bite of an infected tick.

<p>False (B)</p> Signup and view all the answers

CHKV infection can be diagnosed through the detection of virus-specific IgG in serum or CSF.

<p>False (B)</p> Signup and view all the answers

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