23 Questions
What is the primary use of dengue NS1 antigen rapid diagnostic test?
To detect dengue virus in patients with acute febrile illness
What is the advantage of using lateral flow rapid tests for dengue diagnosis?
They can be used in difficult-to-reach areas
What is the relationship between viraemia and antibody responses in dengue diagnosis?
Viraemia is directly related to antibody responses
What is the primary goal of evaluating dengue rapid diagnostic tests?
To compare different diagnostic tests
Which of the following is a limitation of using qRT-PCR for dengue diagnosis?
It requires sophisticated laboratory equipment
What is the primary application of nonstructural 1 enzyme-linked immunosorbent assay (NS1 ELISA) in dengue diagnosis?
To detect dengue virus in patients with acute febrile illness
What is the significance of calculating the average cost per case of dengue fever?
To understand the economic burden of dengue fever
What is the primary advantage of using rapid diagnostic tests in rural areas?
They can be used in areas with limited laboratory infrastructure
What is the term used to describe the severe cases of dengue infection?
Dengue hemorrhagic fever (DHF)
In which climates is dengue infection hyperendemic?
Tropical and subtropical climates
What is the case fatality rate of dengue infection in the Philippines?
0.3%
How many cases of dengue were reported in 2019 in the Philippines?
270,000 cases
What is the recommended repellent for the prevention of dengue?
DEET repellents
How many cases of dengue were reported by mid-October 2022 in the Philippines?
181,971 cases
What is the expected trend of dengue infection in the Philippines and worldwide?
Rapidly spreading
What is the primary purpose of the NS1 Ag-based tests for dengue virus?
To detect dengue virus in the Asian population
According to the Ministry of Health Malaysia, what is the recommended approach for managing dengue in children?
Following the Clinical Practice Guidelines for Management of Dengue in Children
What is the primary advantage of commercial dengue rapid diagnostic tests?
Ease of use and rapid results for point-of-care application
What is a common limitation of rapid immunochromatographic tests for dengue diagnosis?
Low sensitivity and specificity in detecting dengue virus
What is the primary focus of the study by Mata et al. (2017)?
Comparing the accuracy of different rapid diagnostic tests for dengue diagnosis
What is the primary objective of the clinical practice guidelines for management of dengue in children?
To provide evidence-based recommendations for managing dengue in children
What is the primary advantage of using commercial dengue rapid diagnostic tests at the point-of-care setting?
Rapid results and ease of use for healthcare professionals
What is the primary focus of the study by Buonora et al. (2016)?
Investigating the accuracy of clinical criteria and immunochromatographic strip test for dengue diagnosis
Study Notes
Diagnostic Accuracy of NS1 ELISA and Lateral Flow Rapid Tests for Dengue
- Studies have evaluated the diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue.
- These tests have been compared to other diagnostic methods, including qRT-PCR, for their sensitivity and specificity in detecting dengue infections.
Evaluation of Commercial Dengue NS1 Antigen Rapid Diagnostic Tests
- Various studies have evaluated the performance of commercial dengue NS1 antigen rapid diagnostic tests in different settings.
- These tests have shown varying levels of sensitivity and specificity, with some studies reporting high accuracy in detecting dengue infections.
Cost of Dengue Illness to Households
- A study in rural Cambodia found that the cost of dengue illness to households was significant, highlighting the economic burden of the disease.
Guideline for Dengue Management
- The Ministry of Health Malaysia has published clinical practice guidelines for the management of dengue in children.
Accuracy and Reliability of Rapid Diagnostic Tests
- Studies have evaluated the accuracy and reliability of rapid diagnostic tests for dengue, including NS1 antigen-based tests.
- These tests have shown varying levels of accuracy and reliability, with some studies highlighting the need for further evaluation.
Prevention of Dengue Infection
- Recommendations have been made against the use of certain repellents, such as plant-based non-DEET extracts, IR3535, and citronella, for the prevention of dengue infection.
- DEET repellents are recommended for the prevention of dengue infection.
Epidemiology of Dengue in the Philippines
- Dengue is a major public health concern in the Philippines, with high incidence rates reported each year.
- The disease has a case fatality rate of 0.3% in the Philippines.
- The Philippines has reported a high number of dengue cases, with a 91% increase in cases reported in 2022 compared to the previous year.
This quiz covers the diagnostic accuracy and comparison of different tests for dengue, including NS1 ELISA, lateral flow rapid tests, and qRT-PCR. It also explores their relationship to viraemia and antibody responses.
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