Dendritic Cell Antigen Presentation

Dendritic Cells Migration and Maturation

• CCR7 is a chemokine receptor that plays a crucial role in the migration of dendritic cells from peripheral tissues to lymphoid organs, facilitating the initiation of immune responses.

Immature Dendritic Cells in Epithelial Barrier Tissues

• Immature dendritic cells are sentinel cells that reside in epithelial barrier tissues, such as skin and mucosa, where they continuously sample the environment for antigens and provide a first line of defense against invading pathogens.

Costimulators Expressed by Mature Dendritic Cells

• Mature dendritic cells express costimulators, including CD40, CD80, and CD86, which provide the necessary secondary signals for T-cell activation, proliferation, and differentiation.

Maturation of Dendritic Cells and Antigen Presentation

• The maturation of dendritic cells is induced by microbial products, inflammatory cytokines, and CD40 ligand, which enables them to present antigens to T-cells, thereby triggering adaptive immune responses.