4 Questions
What is the function of CCR7 in the migration of dendritic cells?
Attracting dendritic cells to draining lymph nodes
What is the role of immature dendritic cells in epithelial barrier tissues?
Capture microbial antigens
What is the function of costimulators expressed by mature dendritic cells?
Stimulate T cells
What induces the maturation of dendritic cells and their ability to present antigens?
Signals induced by the microbe, such as Toll-like receptor (TLR) signals and cytokines
Study Notes
Dendritic Cells Migration and Maturation
- CCR7 is a chemokine receptor that plays a crucial role in the migration of dendritic cells from peripheral tissues to lymphoid organs, facilitating the initiation of immune responses.
Immature Dendritic Cells in Epithelial Barrier Tissues
- Immature dendritic cells are sentinel cells that reside in epithelial barrier tissues, such as skin and mucosa, where they continuously sample the environment for antigens and provide a first line of defense against invading pathogens.
Costimulators Expressed by Mature Dendritic Cells
- Mature dendritic cells express costimulators, including CD40, CD80, and CD86, which provide the necessary secondary signals for T-cell activation, proliferation, and differentiation.
Maturation of Dendritic Cells and Antigen Presentation
- The maturation of dendritic cells is induced by microbial products, inflammatory cytokines, and CD40 ligand, which enables them to present antigens to T-cells, thereby triggering adaptive immune responses.
Test your knowledge on the capture, transport, and presentation of protein antigens by dendritic cells. Learn about the migration of dendritic cells to draining lymph nodes and the response to signals induced by microbes.
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