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What is the classification of daptomycin?
What is the classification of daptomycin?
- Tetracyclines
- Amino glycosides
- Beta-lactams
- Cyclic lipopeptides (correct)
What is the strength of daptomycin?
What is the strength of daptomycin?
It can rapidly kill virtually all clinically relevant gram-positive bacteria, including methicillin-resistant Staphylococcus aureus.
How does daptomycin work?
How does daptomycin work?
It inserts itself into the bacterial cell membrane and forms channels that allow efflux of intracellular potassium, leading to depolarization of the cell membrane and inhibition of DNA, RNA, and protein synthesis, which causes cell death.
What types of bacteria does daptomycin work against?
What types of bacteria does daptomycin work against?
What are the indications for the use of daptomycin?
What are the indications for the use of daptomycin?
What are the contraindications for daptomycin?
What are the contraindications for daptomycin?
What are the common adverse reactions to daptomycin?
What are the common adverse reactions to daptomycin?
What nursing considerations should be taken into account when administering daptomycin?
What nursing considerations should be taken into account when administering daptomycin?
What should you monitor with daptomycin?
What should you monitor with daptomycin?
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Study Notes
Daptomycin Overview
- Classified as cyclic lipopeptides; represents a new class of antibiotics.
- Rapidly kills most clinically relevant gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
Mechanism of Action
- Inserts into bacterial cell membranes, forming channels.
- Permits efflux of intracellular potassium, leading to depolarization of the cell membrane.
- Inhibits DNA, RNA, and protein synthesis, resulting in cell death.
Spectrum of Activity
- Effective exclusively against gram-positive bacteria.
Indications for Use
- Approved for bloodstream infections caused by Staphylococcus aureus.
- Suitable for complicated skin and skin structure infections from susceptible gram-positive strains.
Contraindications
- Not recommended for community-acquired pneumonia (CAP); associated with higher rates of death and serious cardiopulmonary events compared to equally effective alternatives.
Adverse Reactions
- Common adverse effects include muscle injury, constipation, nausea, diarrhea, injection site reactions, headache, insomnia, and rash.
- Risk of eosinophilic pneumonia may occur.
Nursing Considerations
- Administered once daily via IV infusion.
- Discontinue therapy if patients experience muscle pain or weakness or if creatine phosphokinase (CPK) levels rise to 10 times the upper limit of normal.
Monitoring
- CPK levels should be monitored weekly to assess for potential muscle injury.
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