Podcast
Questions and Answers
Which junction is primarily affected in Pemphigus Vulgaris?
Which junction is primarily affected in Pemphigus Vulgaris?
- Zonula occludens
- Zonula adherens
- Desmosomes (correct)
- Gap junctions
Which cytoskeletal element is considered to have the highest stability according to recent debates?
Which cytoskeletal element is considered to have the highest stability according to recent debates?
- Intermediate filaments (correct)
- Microfilaments
- Actin filaments
- Microtubules
What type of junction helps in cell adhesion to other cells?
What type of junction helps in cell adhesion to other cells?
- Tight junctions
- Gap junctions
- Adherens junctions
- Desmosomes (correct)
What type of filaments are labeled at (1) in the diagram?
What type of filaments are labeled at (1) in the diagram?
Cytoplasmic bundles of actin filaments are primarily attached to which junction type?
Cytoplasmic bundles of actin filaments are primarily attached to which junction type?
Flashcards
Pemphigus Vulgaris
Pemphigus Vulgaris
An autoimmune disease affecting skin and mucous membranes, characterized by blistering. It affects desmosomes.
Cytoskeleton stability
Cytoskeleton stability
Microfilaments (Actin) are generally considered more stable than intermediate filaments.
Cell junctions
Cell junctions
Structures that connect cells, facilitating cell-cell communication and adhesion.
Lung metastasis from colon cancer
Lung metastasis from colon cancer
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Zonula occludens
Zonula occludens
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Zonula adherens
Zonula adherens
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Desmosomes
Desmosomes
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Gap junctions
Gap junctions
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Intermediate filaments
Intermediate filaments
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Microtubules
Microtubules
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Cell Adhesion to Basal Lamina
Cell Adhesion to Basal Lamina
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Cell adhesion to other cells
Cell adhesion to other cells
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Cytoplasmic bundles of actin filaments
Cytoplasmic bundles of actin filaments
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Actin filaments
Actin filaments
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Keratin filaments
Keratin filaments
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Study Notes
Cytoskeleton & Intercellular Junctions
- Pemphigus Vulgaris: Affects desmosomes.
- Soha vs. Tarek Debate: Soha argued microfilaments are most stable, Tarek argued intermediate filaments.
- Intermediate Filaments (IFs): Larger in size, evidence selected for debate in class.
- Cytoskeletal Classifications:
- Main Categories:
- Main Cytoskeletal players
- Cellular Functions
- Main Categories:
- Examples of Cytoskeletal structures:
- Microtubules
- Dynein
- Kinesin
- Vimentin
- Spectrin
- Tetramer
Case Study: Mr. Ahmed
- Diagnosis: Multiple lung metastasis
- Unknown Primary Lesion: Cytokeletal immunocytochemical staining confirmed colon origin
Cellular Structures Identification
- Photos: (Letters and numbers on the photos). Match with structures, with justification for each.
Cell Junction Function
- Function of Cell Junction (3): Helps cell adhesion to other cells.
Filament Types
- Filaments (1): Keratin
Actin Filament Attachment
- Actin Filament Attachment: To zonula adherens.
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