Cytoskeleton & Intercellular Junctions Quiz

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Questions and Answers

Which junction is primarily affected in Pemphigus Vulgaris?

  • Zonula occludens
  • Zonula adherens
  • Desmosomes (correct)
  • Gap junctions

Which cytoskeletal element is considered to have the highest stability according to recent debates?

  • Intermediate filaments (correct)
  • Microfilaments
  • Actin filaments
  • Microtubules

What type of junction helps in cell adhesion to other cells?

  • Tight junctions
  • Gap junctions
  • Adherens junctions
  • Desmosomes (correct)

What type of filaments are labeled at (1) in the diagram?

<p>Keratin (B)</p> Signup and view all the answers

Cytoplasmic bundles of actin filaments are primarily attached to which junction type?

<p>Zonula adherens (C)</p> Signup and view all the answers

Flashcards

Pemphigus Vulgaris

An autoimmune disease affecting skin and mucous membranes, characterized by blistering. It affects desmosomes.

Cytoskeleton stability

Microfilaments (Actin) are generally considered more stable than intermediate filaments.

Cell junctions

Structures that connect cells, facilitating cell-cell communication and adhesion.

Lung metastasis from colon cancer

This describes the spread of cancer cells from the colon to the lungs via the bloodstream; it demonstrates the possible role of the cytoskeleton in cell motility.

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Zonula occludens

Tight junctions; prevent leakage of substances across tissues.

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Zonula adherens

Adherens junctions; connect cells via actin fibers, facilitating adhesion, shaping and stability.

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Desmosomes

Cell adhesion structures; form strong attachments between cells and provide structural integrity.

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Gap junctions

Allow for direct cell-to-cell communication by connecting cytoplasmic channels.

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Intermediate filaments

Cytoskeletal components; provide mechanical strength to cells and tissues.

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Microtubules

Cytoskeletal elements involved in cell division and intracellular transport.

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Cell Adhesion to Basal Lamina

Cell adhesion to basal lamina is aided by specialized cell junctions called hemidesmosomes.

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Cell adhesion to other cells

Adherens junctions, Desmosomes and Tight junctions provide cell adhesion to other cells.

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Cytoplasmic bundles of actin filaments

These bundles are attached to adherens junctions.

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Actin filaments

Thin filaments that form part of the cytoskeleton and are important for cellular movement and structure.

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Keratin filaments

Intermediate filaments found in epithelial cells, providing mechanical strength.

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Study Notes

Cytoskeleton & Intercellular Junctions

  • Pemphigus Vulgaris: Affects desmosomes.
  • Soha vs. Tarek Debate: Soha argued microfilaments are most stable, Tarek argued intermediate filaments.
  • Intermediate Filaments (IFs): Larger in size, evidence selected for debate in class.
  • Cytoskeletal Classifications:
    • Main Categories:
      • Main Cytoskeletal players
      • Cellular Functions
  • Examples of Cytoskeletal structures:
    • Microtubules
    • Dynein
    • Kinesin
    • Vimentin
    • Spectrin
    • Tetramer

Case Study: Mr. Ahmed

  • Diagnosis: Multiple lung metastasis
  • Unknown Primary Lesion: Cytokeletal immunocytochemical staining confirmed colon origin

Cellular Structures Identification

  • Photos: (Letters and numbers on the photos). Match with structures, with justification for each.

Cell Junction Function

  • Function of Cell Junction (3): Helps cell adhesion to other cells.

Filament Types

  • Filaments (1): Keratin

Actin Filament Attachment

  • Actin Filament Attachment: To zonula adherens.

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