Cytokines in Innate and Adaptive Immunity
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Questions and Answers

Which type of immunity do cytokines mediate?

  • Innate immunity
  • Adaptive immunity
  • Both innate and adaptive immunity (correct)
  • None of the above
  • Which of the following is an example of a cytokine involved in innate immunity?

  • IL-4
  • IL-2
  • TNF-a (correct)
  • IFN-g
  • What is the main source of cytokines involved in adaptive immunity?

  • T cells (correct)
  • Dendritic cells
  • NK cells
  • Macrophages
  • In which type of immunity do cytokines typically reach elevated levels detectable in serum?

    <p>Innate immunity</p> Signup and view all the answers

    What type of diseases are commonly associated with systemic effects of cytokines?

    <p>Systemic diseases</p> Signup and view all the answers

    Which of the following is an inhibitor of cytokines?

    <p>Corticoids</p> Signup and view all the answers

    What determines the cell sensitivity to cytokine signals?

    <p>Expression of receptors</p> Signup and view all the answers

    Which cytokine is the main mediator of acute inflammatory responses against gram (-) bacteria and infections?

    <p>TNF-a</p> Signup and view all the answers

    Which cytokine is the main mediator of innate immunity against intracellular pathogens?

    <p>IL-12</p> Signup and view all the answers

    Which cytokine mediates early innate antiviral immune responses?

    <p>Type I IFNs</p> Signup and view all the answers

    Which cytokine is known as the type II IFN?

    <p>Interferon gamma</p> Signup and view all the answers

    Which cytokine is the main stimulus for the synthesis of IgE antibodies and Th2 cell development?

    <p>Interleukin 4</p> Signup and view all the answers

    Which cytokine is responsible for T cell growth factor and clonal expansion after antigen recognition?

    <p>Interleukin 2</p> Signup and view all the answers

    Which cytokine upregulates MHC-I expression and has immunostimulatory properties?

    <p>Interferon gamma</p> Signup and view all the answers

    Which cytokine is produced by leukocytes and has two main groups, including members such as IFN-a and IFN-b?

    <p>Type I IFNs</p> Signup and view all the answers

    Which cytokine has two receptors, TNF-RI (p55) and TNF-RII (p75), with low affinity Kd~10^-9-10^-10?

    <p>TNF-a</p> Signup and view all the answers

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