Cytokines in Innate and Adaptive Immunity
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Questions and Answers

Which type of immunity do cytokines mediate?

  • Innate immunity
  • Adaptive immunity
  • Both innate and adaptive immunity (correct)
  • None of the above

Which of the following is an example of a cytokine involved in innate immunity?

  • IL-4
  • IL-2
  • TNF-a (correct)
  • IFN-g

What is the main source of cytokines involved in adaptive immunity?

  • T cells (correct)
  • Dendritic cells
  • NK cells
  • Macrophages

In which type of immunity do cytokines typically reach elevated levels detectable in serum?

<p>Innate immunity (C)</p> Signup and view all the answers

What type of diseases are commonly associated with systemic effects of cytokines?

<p>Systemic diseases (A)</p> Signup and view all the answers

Which of the following is an inhibitor of cytokines?

<p>Corticoids (D)</p> Signup and view all the answers

What determines the cell sensitivity to cytokine signals?

<p>Expression of receptors (A)</p> Signup and view all the answers

Which cytokine is the main mediator of acute inflammatory responses against gram (-) bacteria and infections?

<p>TNF-a (B)</p> Signup and view all the answers

Which cytokine is the main mediator of innate immunity against intracellular pathogens?

<p>IL-12 (C)</p> Signup and view all the answers

Which cytokine mediates early innate antiviral immune responses?

<p>Type I IFNs (D)</p> Signup and view all the answers

Which cytokine is known as the type II IFN?

<p>Interferon gamma (C)</p> Signup and view all the answers

Which cytokine is the main stimulus for the synthesis of IgE antibodies and Th2 cell development?

<p>Interleukin 4 (C)</p> Signup and view all the answers

Which cytokine is responsible for T cell growth factor and clonal expansion after antigen recognition?

<p>Interleukin 2 (D)</p> Signup and view all the answers

Which cytokine upregulates MHC-I expression and has immunostimulatory properties?

<p>Interferon gamma (D)</p> Signup and view all the answers

Which cytokine is produced by leukocytes and has two main groups, including members such as IFN-a and IFN-b?

<p>Type I IFNs (A)</p> Signup and view all the answers

Which cytokine has two receptors, TNF-RI (p55) and TNF-RII (p75), with low affinity Kd~10^-9-10^-10?

<p>TNF-a (C)</p> Signup and view all the answers

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