Cancer Therapy and Pathology Fundamentals

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What type of malignant neoplasm originates from pigment-producing cells?

Melanoma (correct)

Lymphoma

Colorectal carcinoma

Leukemia

What is the primary mechanism of action of traditional chemotherapy drugs?

Hormone-dependent pathways

Activating the immune system

Inhibiting DNA replication or repair (correct)

Targeting abnormal growth pathways

What is the purpose of testing lung cancer biopsies via PCR for EGFR mutations?

To diagnose lung cancer

To identify patients eligible for Afatinib treatment (correct)

To determine the stage of cancer

To monitor treatment response

What is the role of molecular pathology in cancer diagnosis?

To identify specific genetic markers for targeted therapy Signup and view all the answers

What is the goal of immune checkpoint inhibitors in cancer therapy?

To activate the immune system to eradicate tumor cells Signup and view all the answers

What is the significance of HER2+ status in breast cancer?

It predicts response to trastuzumab Signup and view all the answers

What is the term for an abnormal cellular proliferation with loss of normal architecture?

Dysplasia Signup and view all the answers

What type of neoplasm originates from epithelial cells and is malignant?

Carcinoma Signup and view all the answers

What is the term for a benign tumor of surface epithelium that grows outward in finger-like fibrovascular stalks?

Papilloma Signup and view all the answers

What is the process called when there is a defect in the molecular controls that regulate cellular proliferation and/or cell death?

Neoplasia Signup and view all the answers

What is the term for the formation and proliferation of connective tissues and cells?

Desmoplasia Signup and view all the answers

What type of neoplasm is made up of several different differentiated cell/tissue types?

Teratoma Signup and view all the answers

What is the term for a lump or swelling in cancer terminology?

Tumor Signup and view all the answers

Which type of gene is involved in maintaining the integrity of the genome?

DNA repair gene Signup and view all the answers

What is the term for the process of non-lethal genetic damage that can lead to cancer?

Mutation Signup and view all the answers

Which of the following is an example of an oncogene?

Src Signup and view all the answers

What is the term for the characteristics of cancer cells that distinguish them from normal cells?

Hallmarks of cancer Signup and view all the answers

Which of the following is NOT a type of gene that can contribute to the development of cancer?

Housekeeping gene Signup and view all the answers