Podcast
Questions and Answers
What is the defect in the gene coding for Cystic Fibrosis Transmembrane Regulator (CFTR)?
What is the defect in the gene coding for Cystic Fibrosis Transmembrane Regulator (CFTR)?
What is the commonest autosomal recessive condition?
What is the commonest autosomal recessive condition?
What is the minimum sweat volume required for diagnosis of Cystic Fibrosis?
What is the minimum sweat volume required for diagnosis of Cystic Fibrosis?
What is the sweat chloride concentration indicative of Cystic Fibrosis?
What is the sweat chloride concentration indicative of Cystic Fibrosis?
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Which infection is successfully treated with 3 weeks of oral ciprofloxacin and 3 months of nebulised colomycin at age 7?
Which infection is successfully treated with 3 weeks of oral ciprofloxacin and 3 months of nebulised colomycin at age 7?
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At what age did the individual experience a recurrence of Pseudomonas infection?
At what age did the individual experience a recurrence of Pseudomonas infection?
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What is the age at which Allergic Bronchopulmonary Aspergillosis (ABPA) was diagnosed?
What is the age at which Allergic Bronchopulmonary Aspergillosis (ABPA) was diagnosed?
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What is the age at which the individual had a Mycobacterium Kansasii infection?
What is the age at which the individual had a Mycobacterium Kansasii infection?
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What is the age at which the individual had a successful eradication of Pseudomonas infection with IV therapy?
What is the age at which the individual had a successful eradication of Pseudomonas infection with IV therapy?
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What is the age at which the individual had a Pilocarpine iontophoresis technique done?
What is the age at which the individual had a Pilocarpine iontophoresis technique done?
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What is the age at which the individual had newborn screening for Cystic Fibrosis?
What is the age at which the individual had newborn screening for Cystic Fibrosis?
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Which structure forms from the inner cell mass during implantation?
Which structure forms from the inner cell mass during implantation?
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When does gastrulation, resulting in the formation of three germ layers, occur?
When does gastrulation, resulting in the formation of three germ layers, occur?
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What is the outcome of the divisions of the zygote?
What is the outcome of the divisions of the zygote?
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Where does the zygote implant during the process of implantation?
Where does the zygote implant during the process of implantation?
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What are the two layers of cells that form from the inner cell mass during implantation?
What are the two layers of cells that form from the inner cell mass during implantation?
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What is the most common type of congenital diaphragmatic hernia?
What is the most common type of congenital diaphragmatic hernia?
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What is the prevalence of oesophageal atresia and tracheoesophageal fistula among births?
What is the prevalence of oesophageal atresia and tracheoesophageal fistula among births?
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What is the main cause of respiratory distress syndrome in newborns?
What is the main cause of respiratory distress syndrome in newborns?
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What is the prevalence of congenital pulmonary airway malformation among births?
What is the prevalence of congenital pulmonary airway malformation among births?
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At what stage of lung development do divisions of the alveoli occur, which continues after birth?
At what stage of lung development do divisions of the alveoli occur, which continues after birth?
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Which structure separates the thoracic and abdominopelvic cavities during embryonic development?
Which structure separates the thoracic and abdominopelvic cavities during embryonic development?
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Which phase of lung development involves generational divisions to create the bronchial tree?
Which phase of lung development involves generational divisions to create the bronchial tree?
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What contributes to the development of the larynx during embryonic development?
What contributes to the development of the larynx during embryonic development?
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What separates the trachea and esophagus during embryonic development?
What separates the trachea and esophagus during embryonic development?
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What develops as an outpouching of the foregut during lung development?
What develops as an outpouching of the foregut during lung development?
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Study Notes
Embryonic Development of Body Cavities and Lungs
- Mesoderm develops into paraxial, intermediate, and lateral plate mesoderm
- Lateral plate mesoderm divides into parietal and visceral layers by the development of intraembryonic coelom
- Lateral folding of the embryonic "disc" causes the closing of body walls, entrapping intraembryonic coelom into a closed body cavity
- The continuous primitive body cavities undergo partitioning as lung buds invaginate into pericardioperitoneal canals
- The diaphragm forms to separate thoracic and abdominopelvic cavities
- The diaphragm is composed of septum transversum, pleuroperitoneal membranes, mesentery of the esophagus, and the body wall
- The respiratory diverticulum (lung bud) develops as an outpouching of the foregut, with endoderm and visceral lateral plate mesoderm origin
- Tracheoesophageal ridges fuse to form the tracheoesophageal septum, separating the trachea and esophagus
- Pharyngeal arches 4 and 6 contribute to the development of the larynx
- The internal epithelium of the larynx is from the endoderm, while laryngeal muscles and cartilages come from the fusing of mesenchyme from arches 4 and 6
- Lung development includes generational divisions to create the bronchial tree, with four phases of development
- Lung development includes four phases: pseudoglandular, canalicular, saccular, and alveolar, with each phase having specific characteristics and timeframes
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Description
Test your knowledge of Cystic Fibrosis with this quiz covering its pathophysiology, diagnosis, standard care, and future implications. Explore the commonest autosomal recessive condition, CFTR gene defects, mutations, and associated symptoms.
