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Cyclosporine: Mechanism, Uses, and Adverse Effects Quiz

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Cyclosporine: Mechanism, Uses, and Adverse Effects Quiz

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Questions and Answers

What is the mechanism of action of cyclosporine?

Inhibition of JAK-STAT signaling pathway

Depletion of lymphocyte numbers

Inhibition of calcineurin and inactivation of B-cells

Inhibition of calcineurin and inactivation of T-cells (correct)

Which of the following is a common adverse effect of cyclosporine?

Hypertension and nephrotoxicity (correct)

Increased risk of venous thrombotic events

Increased risk of infections

Bone marrow suppression

How do anticancer drugs like cyclophosphamide and azathioprine work as DMARDs?

They inhibit calcineurin and inactivate T-cells

They suppress the bone marrow, leading to immunosuppression

They deplete the number of lymphocytes, decreasing autoantibody production (correct)

They inhibit the JAK-STAT signaling pathway

Which of the following statements about baricitinib is correct?

Baricitinib inhibits the JAK-STAT signaling pathway Signup and view all the answers

Which of the following is a correct statement about the use of cyclosporine during pregnancy?

Cyclosporine is safe to use during pregnancy (Category C) Signup and view all the answers

What is the mechanism of action of mycophenolate mofetil?

Inhibition of inosine monophosphate dehydrogenase, leading to decreased purine synthesis and lymphocyte proliferation Signup and view all the answers

What is the main adverse effect associated with Adalimumab?

Opportunistic infections Signup and view all the answers

Which inflammatory diseases has Anakinra been approved to treat?

Rheumatoid arthritis Signup and view all the answers

What is the mechanism of action of Sarilumab?

Inhibiting IL-17A cytokine Signup and view all the answers

Which of the following is NOT an adverse effect of IL-6 receptor antagonist (Sarilumab)?

Cardiac arrhythmias Signup and view all the answers

What type of drugs are Secukinumab and Baricitinib classified as?

Anticancer drugs as DMARDs Signup and view all the answers

Which drug inhibits T-cell activation by blocking interaction with CD28 on T cells?

Abatacept Signup and view all the answers

What is the main adverse effect associated with Rituximab?

Stevens Johnson syndrome Signup and view all the answers

Which drug has been reported to reactivate hepatitis B?

Rituximab Signup and view all the answers

What is the category of safety during pregnancy for Rituximab?

Category C Signup and view all the answers

Which of the following drugs inhibits tumor necrosis factor (TNF-a)?

Infliximab Signup and view all the answers

What is the common role of tumor necrosis factor (TNF-a) inhibitors in terms of risk?

Increase the risk of infections like TB Signup and view all the answers