Cushing's Syndrome Clinical Manifestations and Diagnosis

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9 Questions

Which of the following clinical manifestations is NOT typically associated with Cushing's syndrome?

Polyuria

What is the recommended initial management for Cushing's syndrome?

Weaning off glucocorticoids gradually

Which diagnostic test is commonly used to assess cortisol suppression in Cushing's syndrome?

1 mg overnight dexamethasone suppression test

What is the sensitivity of AM cortisol suppression to 1.8 ug/dl in a normal person?

95%

What medication is commonly used to reduce cortisol synthesis in Cushing's syndrome?

Ketoconazole

What can interfere with the accuracy of diagnostic tests for Cushing's syndrome according to the text?

Medications

Which value in the 24-hour urine free cortisol measurements would make Cushing's unlikely?

3 x normal

What is the second-line treatment indicated for Cushing's syndrome after surgical resection?

Meds

'Goals include reducing cortisol levels to normal, eradicating tumors if present, and avoiding permanent hormone deficiency,' according to the text. Which option aligns with these goals?

'Reducing cortisol levels'

Learn about the clinical manifestations and diagnostic challenges of Cushing's syndrome caused by excess ACTH due to a pituitary adenoma. Explore the symptoms such as moon face, buffalo hump, hypertension, poor wound healing, and the workup process to diagnose this condition.

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