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Questions and Answers
What is the primary treatment option for Cushing's disease?
What is the primary treatment option for Cushing's disease?
Which of the following is NOT a potential side effect of radiation therapy for Cushing's disease?
Which of the following is NOT a potential side effect of radiation therapy for Cushing's disease?
What is the potential consequence of pituitary surgery for Cushing's disease?
What is the potential consequence of pituitary surgery for Cushing's disease?
What is the approximate percentage of patients requiring hormone replacement therapy after radiation therapy for Cushing's disease?
What is the approximate percentage of patients requiring hormone replacement therapy after radiation therapy for Cushing's disease?
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How long can it take for radiation therapy to fully take effect in treating Cushing's disease?
How long can it take for radiation therapy to fully take effect in treating Cushing's disease?
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Which of the following medications are used to reduce cortisol production in patients with Cushing's disease?
Which of the following medications are used to reduce cortisol production in patients with Cushing's disease?
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What specific type of symptoms can occur with medications used to reduce cortisol production?
What specific type of symptoms can occur with medications used to reduce cortisol production?
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What is the primary reason for prescribing calcium or vitamin D supplements in patients with Cushing's disease?
What is the primary reason for prescribing calcium or vitamin D supplements in patients with Cushing's disease?
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What is the primary reason for monitoring liver function in patients taking ketoconazole?
What is the primary reason for monitoring liver function in patients taking ketoconazole?
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Which of the following medications can cause high blood pressure in both men and women?
Which of the following medications can cause high blood pressure in both men and women?
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What is the main advantage of the transsphenoidal surgical approach for removing pituitary tumors?
What is the main advantage of the transsphenoidal surgical approach for removing pituitary tumors?
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Which of the following is NOT a potential side effect of mitotane?
Which of the following is NOT a potential side effect of mitotane?
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What is the main reason for monitoring patients with Cushing's syndrome who have undergone adrenalectomy?
What is the main reason for monitoring patients with Cushing's syndrome who have undergone adrenalectomy?
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Which of the following medications can both stop tumor growth and lower ACTH production?
Which of the following medications can both stop tumor growth and lower ACTH production?
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Why should ketoconazole and mitotane not be given to women planning on having children?
Why should ketoconazole and mitotane not be given to women planning on having children?
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What is the main side effect of cabergoline?
What is the main side effect of cabergoline?
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What is the primary purpose of taking fludrocortisone after adrenalectomy?
What is the primary purpose of taking fludrocortisone after adrenalectomy?
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Which medication is approved for the treatment of high blood sugar caused by Cushing's syndrome?
Which medication is approved for the treatment of high blood sugar caused by Cushing's syndrome?
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What percentage of patients experience normalized urine cortisol levels after treatment with pasireotide?
What percentage of patients experience normalized urine cortisol levels after treatment with pasireotide?
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Which treatment option involves removing the tumor and leaving the rest of the pituitary gland intact?
Which treatment option involves removing the tumor and leaving the rest of the pituitary gland intact?
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What is the approximate success rate of surgery for Cushing's disease, performed by experienced pituitary surgeons?
What is the approximate success rate of surgery for Cushing's disease, performed by experienced pituitary surgeons?
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Which treatment option is used to block the effects of cortisol in the entire body?
Which treatment option is used to block the effects of cortisol in the entire body?
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What is the main reason for tumor recurrence after surgery?
What is the main reason for tumor recurrence after surgery?
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What is the primary function of mifepristone in the treatment of Cushing's disease?
What is the primary function of mifepristone in the treatment of Cushing's disease?
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What is required for patients who have had their adrenal glands removed?
What is required for patients who have had their adrenal glands removed?
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What hormone can be lost if the posterior part of the pituitary is damaged?
What hormone can be lost if the posterior part of the pituitary is damaged?
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What imaging technique may be used to evaluate the pituitary gland after adrenal surgery?
What imaging technique may be used to evaluate the pituitary gland after adrenal surgery?
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What is a common symptom experienced by patients whose adrenal glands have been removed?
What is a common symptom experienced by patients whose adrenal glands have been removed?
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What is a potential consequence of damaged structures during pituitary surgery?
What is a potential consequence of damaged structures during pituitary surgery?
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What treatment option may be considered if the first transsphenoidal operation is unsuccessful?
What treatment option may be considered if the first transsphenoidal operation is unsuccessful?
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What can a daily dose of a nasal spray or pill replace if anti-diuretic hormone is lost?
What can a daily dose of a nasal spray or pill replace if anti-diuretic hormone is lost?
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Which therapy can be considered for treating the pituitary gland if a tumor is not found during surgery?
Which therapy can be considered for treating the pituitary gland if a tumor is not found during surgery?
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If the body is regulating cortisol correctly, what happens to cortisol levels?
If the body is regulating cortisol correctly, what happens to cortisol levels?
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Which of the following is NOT a common symptom of Cushing's syndrome in adults?
Which of the following is NOT a common symptom of Cushing's syndrome in adults?
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What is the best way to differentiate between Cushing's syndrome and a pseudo-Cushing's state?
What is the best way to differentiate between Cushing's syndrome and a pseudo-Cushing's state?
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Why might an individual with Cushing's syndrome experience muscle weakness?
Why might an individual with Cushing's syndrome experience muscle weakness?
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What is one potential consequence of Cushing's syndrome on a woman's menstrual cycle?
What is one potential consequence of Cushing's syndrome on a woman's menstrual cycle?
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What is the primary function of cortisol in the body?
What is the primary function of cortisol in the body?
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Which of the following accurately describes the mechanism of action of mifepristone in the treatment of Cushing's syndrome?
Which of the following accurately describes the mechanism of action of mifepristone in the treatment of Cushing's syndrome?
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Pasireotide, a medication used for Cushing's disease, demonstrates effectiveness by:
Pasireotide, a medication used for Cushing's disease, demonstrates effectiveness by:
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What is the primary difference between Cushing's disease and Cushing's syndrome?
What is the primary difference between Cushing's disease and Cushing's syndrome?
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If a patient's urine cortisol levels are less than twice the normal value at the start of treatment, which medication might be most effective?
If a patient's urine cortisol levels are less than twice the normal value at the start of treatment, which medication might be most effective?
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Which of the following describes the role of the adrenal glands in the development of Cushing's syndrome?
Which of the following describes the role of the adrenal glands in the development of Cushing's syndrome?
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Which of the following is a direct consequence of excessive ACTH production?
Which of the following is a direct consequence of excessive ACTH production?
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What is the purpose of using synthetic CRH in a medical setting?
What is the purpose of using synthetic CRH in a medical setting?
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What is the underlying cause of Cushing's syndrome when it is classified as "Ectopic ACTH"?
What is the underlying cause of Cushing's syndrome when it is classified as "Ectopic ACTH"?
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Flashcards
Cushing's Syndrome
Cushing's Syndrome
A condition caused by excess cortisol in the body, often due to ACTH levels.
ACTH
ACTH
Adrenocorticotropic hormone, which stimulates cortisol production in the adrenal glands.
Pituitary Surgery
Pituitary Surgery
A surgical method to remove tumors causing Cushing's disease, though not always 100% successful.
Radiation Therapy
Radiation Therapy
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Hormone Replacement
Hormone Replacement
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Medications for Cushing's
Medications for Cushing's
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Complementary Approaches
Complementary Approaches
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Surgical Removal of Tumor
Surgical Removal of Tumor
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Ketoconazole
Ketoconazole
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Metyrapone
Metyrapone
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Transsphenoidal surgery
Transsphenoidal surgery
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Adrenal gland removal
Adrenal gland removal
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Fludrocortisone
Fludrocortisone
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Cushing’s syndrome
Cushing’s syndrome
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Pasireotide
Pasireotide
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MRI scans for tumors
MRI scans for tumors
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Cortisol Regulation
Cortisol Regulation
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Pseudo-Cushing's States
Pseudo-Cushing's States
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Common Symptoms of Cushing's
Common Symptoms of Cushing's
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Weight Gain in Cushing's
Weight Gain in Cushing's
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Laboratory Tests
Laboratory Tests
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Impact on Memory and Mood
Impact on Memory and Mood
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Muscle Weakness
Muscle Weakness
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Cabergoline
Cabergoline
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Mifepristone
Mifepristone
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Pituitary Tumor Recurrence
Pituitary Tumor Recurrence
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Surgical Success Rate
Surgical Success Rate
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Urine Cortisol Normalization
Urine Cortisol Normalization
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Endocrinologist Role
Endocrinologist Role
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Hydrocortisone Increase
Hydrocortisone Increase
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MRI Imaging
MRI Imaging
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Diabetes Insipidus
Diabetes Insipidus
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Antidiuretic Hormone
Antidiuretic Hormone
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Pituitary Tumor Risks
Pituitary Tumor Risks
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Second Operation Options
Second Operation Options
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Radiation Therapy Risks
Radiation Therapy Risks
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Adrenal Glands
Adrenal Glands
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Cortisol
Cortisol
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Ectopic ACTH
Ectopic ACTH
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Adrenalectomy
Adrenalectomy
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CRH (Corticotropin-releasing hormone)
CRH (Corticotropin-releasing hormone)
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Cushing’s Disease
Cushing’s Disease
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Study Notes
Cushing's Syndrome and Cushing's Disease
- Cushing's syndrome is a rare condition caused by excess cortisol in the body.
- Cortisol is a hormone vital for responding to stress, illness or injury.
- It affects many body tissues.
- Cortisol is produced in varying amounts throughout the day, highest in the morning, lowest at night.
- Cushing's syndrome occurs when the body has too much cortisol, regardless of the cause.
- Cushing's disease is a type of Cushing's syndrome caused by a pituitary tumor.
Causes
- Cushing's syndrome can be caused by prolonged use of cortisol-like medications (glucocorticoids).
- It can also be caused by an adrenal gland tumor producing excess cortisol.
- A pituitary tumor (Cushing's disease) produces adrenocorticotropic hormone (ACTH) which stimulates the adrenal glands & cortisol production.
- Ectopic ACTH-producing tumors, outside the pituitary, can also cause the condition.
Symptoms
- Common: Weight gain (especially in the trunk), high blood pressure (hypertension), changes in memory and mood.
- Less Common: Insomnia, recurrent infections, thin skin & stretch marks, easy bruising, depression, weak bones, acne, hair loss (women), swelling in the feet.
Diagnosis
- Based on symptoms, but not always conclusive due to overlap with other conditions.
- Laboratory tests measure cortisol levels in saliva or urine.
- Dexamethasone suppression test determines if the body is appropriately regulating cortisol.
- Inferior petrosal sinus sampling (IPSS) is used to differentiate between pituitary and other causes of excess ACTH.
- MRI scans can visualize the pituitary gland, looking for tumors.
Treatment for Cushing's Disease
- Surgery to remove the pituitary tumor (transsphenoidal surgery) is the primary treatment when feasible.
- Radiation therapy (to the pituitary) is an option, especially when surgical removal proves challenging or unavailable, and results may take some time to manifest, and may cause further complications or requiring life-long replacement therapy for other hormones .
- Various medications can control cortisol overproduction (example Cabergoline Pasireotide or Mefepristone), but they don't necessarily remove a tumor and may require ongoing monitoring and potentially dose adjustments..
- Removal of both adrenal glands is a last resort; this necessitates lifelong cortisol replacement therapy.
Post-Treatment Considerations
- Significant time and recovery is often needed following treatment.
- Flu-like symptoms, nausea, pain, fatigue are common.
- Medication dosage adjustment for cortisol (e.g., hydrocortisone or prednisone) is needed until normal balance is restored.
- Recovering from the condition and treating complications may take several months.
- Monitoring of blood sugar levels and other symptoms is crucial.
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Description
Test your knowledge on Cushing's syndrome and Cushing's disease. This quiz will cover the causes, symptoms, and the hormonal functions of cortisol in relation to these conditions. Understand the differences and implications of excess cortisol in the body.