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Creatinine Determination

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Questions and Answers

Which enzyme catalyzes the synthesis of creatine?

MAT
GAMT (correct)
SAM
AGAT

What is the primary function of l-arginine:glycine amidinotransferase (AGAT)?

To form guanidinoacetate for energy production in muscle contraction (correct)
To catalyze the synthesis of creatine
To transport creatine to other tissues
To provide methyl group through methionine adenosyltransferase (MAT)

Which molecule accounts for the methyl group provided by S-adenosylmethionine (SAM)?

Arginine
Glycine
Creatine
Methionine (correct)

How is creatine transported to other tissues such as muscle?

Mediated by the creatine transporter through secondary active transport by sodium/chloride-ATPase generated gradient (B) Signup and view all the answers

What is formed when creatine phosphate loses a phosphoric acid and then loses water?

Creatinine (D) Signup and view all the answers

What is the primary source of creatinine in the body?

Breakdown of creatine phosphate in muscle (A) Signup and view all the answers

What is the relationship between plasma creatinine and glomerular filtration rate (GFR)?

Inversely related (B) Signup and view all the answers

Why is plasma creatinine considered a more reliable screening test for renal function than Blood Urea Nitrogen (BUN)?

Less influenced by diet and hydration (B) Signup and view all the answers

What does creatinine clearance measure?

The amount of creatinine eliminated from the blood by the kidneys (C) Signup and view all the answers

What is Glomerular Filtration Rate (GFR) used to gauge?

Renal function (C) Signup and view all the answers