Creatinine Determination

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Questions and Answers

Which enzyme catalyzes the synthesis of creatine?

  • MAT
  • GAMT (correct)
  • SAM
  • AGAT

What is the primary function of l-arginine:glycine amidinotransferase (AGAT)?

  • To form guanidinoacetate for energy production in muscle contraction (correct)
  • To catalyze the synthesis of creatine
  • To transport creatine to other tissues
  • To provide methyl group through methionine adenosyltransferase (MAT)

Which molecule accounts for the methyl group provided by S-adenosylmethionine (SAM)?

  • Arginine
  • Glycine
  • Creatine
  • Methionine (correct)

How is creatine transported to other tissues such as muscle?

<p>Mediated by the creatine transporter through secondary active transport by sodium/chloride-ATPase generated gradient (B)</p> Signup and view all the answers

What is formed when creatine phosphate loses a phosphoric acid and then loses water?

<p>Creatinine (D)</p> Signup and view all the answers

What is the primary source of creatinine in the body?

<p>Breakdown of creatine phosphate in muscle (A)</p> Signup and view all the answers

What is the relationship between plasma creatinine and glomerular filtration rate (GFR)?

<p>Inversely related (B)</p> Signup and view all the answers

Why is plasma creatinine considered a more reliable screening test for renal function than Blood Urea Nitrogen (BUN)?

<p>Less influenced by diet and hydration (B)</p> Signup and view all the answers

What does creatinine clearance measure?

<p>The amount of creatinine eliminated from the blood by the kidneys (C)</p> Signup and view all the answers

What is Glomerular Filtration Rate (GFR) used to gauge?

<p>Renal function (C)</p> Signup and view all the answers

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