36 Questions
What is the minimum daily dosage of Sulbactam required for effective treatment of CRAB infections in critically ill patients?
6 grams
What percentage of patients who received Colistin monotherapy showed clinical improvement by day 5 in a clinical study?
16%
What is a limitation of the clinical study involving 39 patients with CRAB pneumonia?
All of the above
What was the total daily dosage of Sulbactam used in a comparative study involving 47 patients with CRAB pneumonia?
6 grams
What was the outcome of two additional clinical studies on the use of Ampicillin/Sulbactam for CRAB infections?
No difference in clinical outcomes
What is a benefit of using Sulbactam-based treatment plans compared to Polymyxin-based treatment plans?
Less frequent nephrotoxicity
What is the recommended daily dosage of Sulbactam for CRAB infections?
6-9 grams
What is the role of Durlobactam in the treatment of CRAB infections?
It provides protection and enhances the likelihood of Sulbactam reaching its PBP targets
What was the outcome of the RCT comparing Ampicillin/Sulbactam to Colistin in treating ventilator-associated pneumonia (VAP) caused by CRAB?
Both treatment options yielded comparable outcomes
What was the outcome of the retrospective cohort study comparing low-dose Colistin to Ampicillin/Sulbactam in treating CRAB VAP?
There was no significant difference in clinical failure between the two treatment groups
What was the outcome of the small randomized controlled trial comparing Ampicillin/Sulbactam to Colistin in treating CRAB VAP?
Ampicillin/Sulbactam showed significant improvement in 14-day and 28-day mortality rates
What is the comparison between Sulbactam/Durlobactam and Ampicillin/Sulbactam in terms of nephrotoxicity?
Both treatment groups have comparable incidence of nephrotoxicity
What is the role of β-Lactamase inhibitors in the treatment of CRAB infections?
They inhibit CRAB-generated class A, C, and D enzymes
What was the outcome of the retrospective cohort study comparing Tigecycline to Sulbactam for treating hospital-acquired infections caused by CRAB bacteria?
There was no significant difference in 30-day mortality rates between the two groups
What is the recommended treatment approach for CRAB infections according to the guideline?
Using Ampicillin/Sulbactam in high doses as the primary component in combination therapy
What is the current status of Sulbactam/Durlobactam in terms of FDA approval?
It has completed phase 3 clinical testing but is not yet approved by the FDA
What was the significant advantage of Sulbactam-based treatment in a Taiwanese multicenter study?
Lower incidence of death in the ICU
What is the general association between Tigecycline and hospital-acquired pneumonia, ventilator-associated pneumonia, and bloodstream infections?
Higher mortality risk
What is the characteristic of Diazabicyclooctanones (DBOs) that makes them difficult to synthesize?
Requires a minimum of 12 synthetic steps
What is the unique feature of Avibactam's inhibitory mechanism?
It has a broad spectrum of action against Class A, Class C, and some Class D enzymes
What is the potential of combinations of BL-ABs/2nd generation BLIs?
Extremely successful against a wide range of multidrug-resistant bacteria
What has been observed in various studies regarding the novel combination Ceftazidime/Avibactam?
Emerging resistance
What is the proposed therapeutic option for severe infections caused by MDR-GNB producing Class B Metallo-β-Lactamase?
Aztreonam/Avibactam
What is the characteristic of Aztreonam?
Resistant to MBLs hydrolysis
What percentage of patients infected by E.cloacae and P. aeruginosa showed resistance to the Ceftazidime/Avibactam combination?
8%
What is the benefit of using structure-based drug design and computational and medicinal chemistry in the development of DBO derivatives?
Simplifies the synthesis process
What is the reason for the resistance of P.aeruginosa to Ceftazidime/Avibactam?
Impaired membrane permeability and drug efflux
What is the effect of a single amino acid substitution in the loop of KPC on Avibactam's inhibition capacity?
Decreases Avibactam's inhibition capacity
What is the effect of the D179Y substitution on the MICs of Ampicillin, Ceftriaxone, Aztreonam, and Meropenem?
Decreases the MICs
What is the ratio of BL-AB to 2nd generation BLI required for Relebactam to be effective?
22:1
What is the mechanism of inhibition of Zidebactam?
Binding to PBP2 in Enterobacteriaceae and P.aeruginosa
What is the effect of mutations that render Avibactam ineffective on the susceptibility of certain 1st generation BLIs?
Increases susceptibility
What is the characteristic of Nacubactam that differentiates it from Avibactam and Relebactam?
Showing activity against XDR-E isolates
What is the combination of antibiotics being developed to combat Pan-drug resistant Enterobacteriaceae and Pseudomonas species?
Cefepime/Zidebactam
What is the reason for the resistance of Klebsiella pneumonia to Ceftazidime/Avibactam?
A single amino acid substitution in the loop of KPC
What is the characteristic of Avibactam that is not shared with Relebactam?
Having a small intrinsic antibacterial activity against E.coli and H.influenzae
Explore the effectiveness of different treatment regimens for CRAB infections, including the administration of Ampicillin/Sulbactam and other medications. Learn about the optimal dosage and potential side effects of these treatments. Quiz yourself on the latest research and findings!
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