Podcast
Questions and Answers
What is the minimum daily dosage of Sulbactam required for effective treatment of CRAB infections in critically ill patients?
What is the minimum daily dosage of Sulbactam required for effective treatment of CRAB infections in critically ill patients?
- 10 grams
- 8 grams
- 6 grams (correct)
- 4 grams
What percentage of patients who received Colistin monotherapy showed clinical improvement by day 5 in a clinical study?
What percentage of patients who received Colistin monotherapy showed clinical improvement by day 5 in a clinical study?
- 10%
- 40%
- 30%
- 16% (correct)
What is a limitation of the clinical study involving 39 patients with CRAB pneumonia?
What is a limitation of the clinical study involving 39 patients with CRAB pneumonia?
- Small sample size
- Lack of Sulbactam usage
- Open-label design
- All of the above (correct)
What was the total daily dosage of Sulbactam used in a comparative study involving 47 patients with CRAB pneumonia?
What was the total daily dosage of Sulbactam used in a comparative study involving 47 patients with CRAB pneumonia?
What was the outcome of two additional clinical studies on the use of Ampicillin/Sulbactam for CRAB infections?
What was the outcome of two additional clinical studies on the use of Ampicillin/Sulbactam for CRAB infections?
What is a benefit of using Sulbactam-based treatment plans compared to Polymyxin-based treatment plans?
What is a benefit of using Sulbactam-based treatment plans compared to Polymyxin-based treatment plans?
What is the recommended daily dosage of Sulbactam for CRAB infections?
What is the recommended daily dosage of Sulbactam for CRAB infections?
What is the role of Durlobactam in the treatment of CRAB infections?
What is the role of Durlobactam in the treatment of CRAB infections?
What was the outcome of the RCT comparing Ampicillin/Sulbactam to Colistin in treating ventilator-associated pneumonia (VAP) caused by CRAB?
What was the outcome of the RCT comparing Ampicillin/Sulbactam to Colistin in treating ventilator-associated pneumonia (VAP) caused by CRAB?
What was the outcome of the retrospective cohort study comparing low-dose Colistin to Ampicillin/Sulbactam in treating CRAB VAP?
What was the outcome of the retrospective cohort study comparing low-dose Colistin to Ampicillin/Sulbactam in treating CRAB VAP?
What was the outcome of the small randomized controlled trial comparing Ampicillin/Sulbactam to Colistin in treating CRAB VAP?
What was the outcome of the small randomized controlled trial comparing Ampicillin/Sulbactam to Colistin in treating CRAB VAP?
What is the comparison between Sulbactam/Durlobactam and Ampicillin/Sulbactam in terms of nephrotoxicity?
What is the comparison between Sulbactam/Durlobactam and Ampicillin/Sulbactam in terms of nephrotoxicity?
What is the role of β-Lactamase inhibitors in the treatment of CRAB infections?
What is the role of β-Lactamase inhibitors in the treatment of CRAB infections?
What was the outcome of the retrospective cohort study comparing Tigecycline to Sulbactam for treating hospital-acquired infections caused by CRAB bacteria?
What was the outcome of the retrospective cohort study comparing Tigecycline to Sulbactam for treating hospital-acquired infections caused by CRAB bacteria?
What is the recommended treatment approach for CRAB infections according to the guideline?
What is the recommended treatment approach for CRAB infections according to the guideline?
What is the current status of Sulbactam/Durlobactam in terms of FDA approval?
What is the current status of Sulbactam/Durlobactam in terms of FDA approval?
What was the significant advantage of Sulbactam-based treatment in a Taiwanese multicenter study?
What was the significant advantage of Sulbactam-based treatment in a Taiwanese multicenter study?
What is the general association between Tigecycline and hospital-acquired pneumonia, ventilator-associated pneumonia, and bloodstream infections?
What is the general association between Tigecycline and hospital-acquired pneumonia, ventilator-associated pneumonia, and bloodstream infections?
What is the characteristic of Diazabicyclooctanones (DBOs) that makes them difficult to synthesize?
What is the characteristic of Diazabicyclooctanones (DBOs) that makes them difficult to synthesize?
What is the unique feature of Avibactam's inhibitory mechanism?
What is the unique feature of Avibactam's inhibitory mechanism?
What is the potential of combinations of BL-ABs/2nd generation BLIs?
What is the potential of combinations of BL-ABs/2nd generation BLIs?
What has been observed in various studies regarding the novel combination Ceftazidime/Avibactam?
What has been observed in various studies regarding the novel combination Ceftazidime/Avibactam?
What is the proposed therapeutic option for severe infections caused by MDR-GNB producing Class B Metallo-β-Lactamase?
What is the proposed therapeutic option for severe infections caused by MDR-GNB producing Class B Metallo-β-Lactamase?
What is the characteristic of Aztreonam?
What is the characteristic of Aztreonam?
What percentage of patients infected by E.cloacae and P. aeruginosa showed resistance to the Ceftazidime/Avibactam combination?
What percentage of patients infected by E.cloacae and P. aeruginosa showed resistance to the Ceftazidime/Avibactam combination?
What is the benefit of using structure-based drug design and computational and medicinal chemistry in the development of DBO derivatives?
What is the benefit of using structure-based drug design and computational and medicinal chemistry in the development of DBO derivatives?
What is the reason for the resistance of P.aeruginosa to Ceftazidime/Avibactam?
What is the reason for the resistance of P.aeruginosa to Ceftazidime/Avibactam?
What is the effect of a single amino acid substitution in the loop of KPC on Avibactam's inhibition capacity?
What is the effect of a single amino acid substitution in the loop of KPC on Avibactam's inhibition capacity?
What is the effect of the D179Y substitution on the MICs of Ampicillin, Ceftriaxone, Aztreonam, and Meropenem?
What is the effect of the D179Y substitution on the MICs of Ampicillin, Ceftriaxone, Aztreonam, and Meropenem?
What is the ratio of BL-AB to 2nd generation BLI required for Relebactam to be effective?
What is the ratio of BL-AB to 2nd generation BLI required for Relebactam to be effective?
What is the mechanism of inhibition of Zidebactam?
What is the mechanism of inhibition of Zidebactam?
What is the effect of mutations that render Avibactam ineffective on the susceptibility of certain 1st generation BLIs?
What is the effect of mutations that render Avibactam ineffective on the susceptibility of certain 1st generation BLIs?
What is the characteristic of Nacubactam that differentiates it from Avibactam and Relebactam?
What is the characteristic of Nacubactam that differentiates it from Avibactam and Relebactam?
What is the combination of antibiotics being developed to combat Pan-drug resistant Enterobacteriaceae and Pseudomonas species?
What is the combination of antibiotics being developed to combat Pan-drug resistant Enterobacteriaceae and Pseudomonas species?
What is the reason for the resistance of Klebsiella pneumonia to Ceftazidime/Avibactam?
What is the reason for the resistance of Klebsiella pneumonia to Ceftazidime/Avibactam?
What is the characteristic of Avibactam that is not shared with Relebactam?
What is the characteristic of Avibactam that is not shared with Relebactam?
