Podcast
Questions and Answers
A patient with a history of peptic ulcers requires an analgesic. Which of the following medications would be LEAST appropriate due to its primary mechanism of action?
A patient with a history of peptic ulcers requires an analgesic. Which of the following medications would be LEAST appropriate due to its primary mechanism of action?
- Celecoxib
- Acetaminophen
- Ibuprofen
- Low-dose aspirin (correct)
A patient experiences pain and inflammation but has a known hypersensitivity to traditional NSAIDs. Which of the following would be the MOST appropriate alternative for managing their symptoms?
A patient experiences pain and inflammation but has a known hypersensitivity to traditional NSAIDs. Which of the following would be the MOST appropriate alternative for managing their symptoms?
- Ketoprofen
- Ketorolac
- Celecoxib (correct)
- Naproxen
Which of the following drugs carries the LOWEST risk of causing gastrointestinal side effects at typical analgesic doses?
Which of the following drugs carries the LOWEST risk of causing gastrointestinal side effects at typical analgesic doses?
- Ketoprofen
- Naproxen
- Celecoxib (correct)
- Ibuprofen
Following an acetaminophen overdose, which antidote is administered to prevent liver damage?
Following an acetaminophen overdose, which antidote is administered to prevent liver damage?
A patient requires an analgesic with minimal anti-inflammatory effects. Which of the following would be MOST suitable?
A patient requires an analgesic with minimal anti-inflammatory effects. Which of the following would be MOST suitable?
Flashcards
Selective COX-1 Inhibitors
Selective COX-1 Inhibitors
Selectively block COX-1 enzymes, reducing prostaglandin production. Examples: Ketorolac, ketoprofen, low-dose aspirin.
Selective COX-2 Inhibitors
Selective COX-2 Inhibitors
Primarily inhibit COX-2 enzymes, reducing inflammation and pain. Examples: Celecoxib, valecoxib, diclofenac.
Non-Selective COX Inhibitors
Non-Selective COX Inhibitors
Inhibit both COX-1 and COX-2 enzymes, providing pain relief and anti-inflammatory effects. Examples: Naproxen, ibuprofen.
Acetaminophen (Paracetamol)
Acetaminophen (Paracetamol)
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Low-Dose Aspirin (as COX-1 Inhibitor)
Low-Dose Aspirin (as COX-1 Inhibitor)
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Study Notes
- Selective COX-1 inhibitors include ketolorac, ketoprofen.
- Low dose aspirin is an irreversible COX-1 inhibitor.
- Selective COX-2 inhibitors include celecoxib, valecoxib, and diclofenac.
- Non-selective COX inhibitors include naproxen and ibuprofen.
- Acetaminophen, also known as paracetamol, is not an NSAID.
- Acetaminophenreduces pain and fever.
- The antidote for acetaminophen is NAD.
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Description
This lesson covers selective and non-selective COX inhibitors like ketolorac, celecoxib, naproxen, and ibuprofen. It also discusses low-dose aspirin as an irreversible COX-1 inhibitor. Furthermore, it explains acetaminophen's effects and its antidote, NAD.
