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Questions and Answers
What is the main determinant of coronavirus tropism?
What is the main determinant of coronavirus tropism?
- Spike glycoprotein (correct)
- Membrane protein
- Envelope protein
- Nucleocapsid protein
Which sinus is most commonly involved in sinus infections?
Which sinus is most commonly involved in sinus infections?
- Sphenoid sinus
- Maxillary sinus (correct)
- Ethmoid sinus
- Frontal sinus
What is the function of the S2 subunit of the spike glycoprotein?
What is the function of the S2 subunit of the spike glycoprotein?
- Forms trimers on the surface of virions
- Encodes a set of structural proteins
- Mediates membrane fusion (correct)
- Binds to the host entry receptor ACE2
What protein is responsible for transporting mucus out of the sinuses?
What protein is responsible for transporting mucus out of the sinuses?
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What characterizes chronic sinusitis?
What characterizes chronic sinusitis?
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How do viruses belonging to Sabercovirus interact with host cells?
How do viruses belonging to Sabercovirus interact with host cells?
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Study Notes
Coronavirus Tropism
- The main determinant of coronavirus tropism is the receptor-binding domain (RBD) of the spike glycoprotein.
- The RBD interacts with specific host cell receptors, determining which cells the virus can infect.
Sinus Infections
- The maxillary sinus is the most commonly involved in sinus infections.
Spike Glycoprotein
- The S2 subunit of the spike glycoprotein is responsible for membrane fusion, allowing the viral genome to enter the host cell.
Mucus Transport
- The cilia located in the epithelial lining of the sinuses are responsible for transporting mucus out of the sinuses.
Chronic Sinusitis
- Chronic sinusitis is characterized by inflammation of the sinuses lasting more than 12 weeks.
Sabercovirus
- Sabercoviruses utilize a unique mechanism to interact with host cells.
- They employ a viral glycoprotein that binds to host cell receptors and triggers endocytosis, bringing the virus into the cell.
- This process involves viral entry and subsequent replication, ultimately leading to viral propagation.
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