Corticosteroids Therapy and Supplements

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Questions and Answers

What is the mechanism of action of Anticholinergics bronchodilators?

Non-competitive antagonists of Ach at the nicotinic receptor

Non-competitive agonists of Ach at the nicotinic receptor

Competitive agonists of Ach at the muscarinic receptor

Competitive antagonists of Ach at the muscarinic receptor (correct)

Urinary retention is a systemic side effect of Anticholinergics bronchodilators.

True

What is the duration of action of Tiotropium Bromide?

24 hours

Ipratropium is a _____________ acting Anticholinergics bronchodilator.

short Signup and view all the answers

Match the following Anticholinergics bronchodilators with their duration of action:

Ipratropium = 2-4 hours Tiotropium Bromide = 24 hours Oxitropium = 4-6 hours Signup and view all the answers

What is a contraindication for the use of Anticholinergics bronchodilators?

Narrow-angle glaucoma Signup and view all the answers

What are the classical antiasthma drugs?

Bronchodilators and Antiinflammatory corticosteroids Signup and view all the answers

Inhaled corticosteroids are used to reduce bronchial smooth muscle constriction.

False Signup and view all the answers

What is the primary goal of asthma management?

To control symptoms and prevent attacks Signup and view all the answers

Inhalational devices are used to deliver antiasthma drugs directly to the __________.

lungs Signup and view all the answers

Match the following antiasthma drugs with their mechanism of action:

Bronchodilators = Reduce bronchial smooth muscle constriction Inhaled corticosteroids = Reduce inflammation β2 receptor agonists = Stimulate bronchial smooth muscle relaxation Glucocorticoids = Suppress immune response Signup and view all the answers

What is an essential supplemental measure during Glucocorticoids (GC) therapy?

Diet rich in potassium and low in sodium Signup and view all the answers

Inhaler technique mistakes are relatively rare among asthma patients.

False Signup and view all the answers

What is the purpose of Alendronate biphosphonate in GC therapy?

To inhibit osteoclast activity Signup and view all the answers

Patients treated with corticosteroids should be on a ______ diet.

high protein Signup and view all the answers

Match the following inhalational drug delivery systems with their descriptions:

Pressurized metered-dose inhalers = Requires coordination between breathing and actuation Breath actuated inhalers = Does not require coordination between breathing and actuation Nebulizer = Converts liquid medication into an aerosol Signup and view all the answers

What is a common issue with asthma prescriptions?

Inadequate prescription of asthma medications Signup and view all the answers

Spacer use is not recommended for children with pressurized metered-dose inhalers.

False Signup and view all the answers

About ______% of patients may not adhere to their prescribed asthma treatment.

80 Signup and view all the answers

Study Notes

Corticosteroids/Glucocorticoids

Patients treated with corticosteroids should be on a high protein diet
Supplemental measures during GC therapy include:
- Diet rich in potassium and low in sodium
- Caloric management to prevent obesity
- High protein intake
- Appropriate antacid therapy
- Calcium and Vit D
- Alendronate biphosphonate to inhibit osteoclast activity

Inhalational Drug Delivery Systems

Pressurized metered-dose inhalers are used for asthma treatment
In children, pressurized metered-dose inhalers are best used with a spacer
Nebulizers are also used for asthma treatment

Pharmaceutical Care Issues

Inadequate prescription: about 40% of asthma patients may not have adequate prescription of asthma medications according to guidelines
Low adherence: about 80% of patients may not adhere to their prescribed treatment
Inhaler technique mistakes: approximately 17% of patients made critical mistakes with their inhaler technique

Classification of Asthma

Asthma can be classified based on the severity of symptoms

Antiasthma Drugs

Classical antiasthma drugs are:
- Bronchodilators
- Anti-inflammatory corticosteroids

Bronchodilators

β2 receptor agonists are a type of bronchodilator
Anticholinergics are a type of bronchodilator
- Examples: Ipratropium, Oxitropium, Tiotropium Bromide
- Mechanism: competitive antagonists of Ach at the muscarinic receptor
- Side effects: local (dry mouth, pharyngeal irritation), systemic (urinary retention, loss of accommodation, tachycardia, agitation, increased intraocular pressure)
- Contraindications: known hypersensitivity, narrow-angle glaucoma, gastrointestinal tract obstructions, urinary retention

Other Bronchodilators

Magnesium Sulphate is a bronchodilator

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Description

This quiz covers the supplemental measures to be taken while on corticosteroid therapy, including dietary recommendations and medications to prevent various complications.