Correct Use of pMDIs and Breath-Actuated MDIs

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Questions and Answers

What is the approximate size of the particles produced from the flashing of propellant in a pMDI?

Aerosolization begins when the propellant leaves the actuator
35 µM (correct)
20 milliseconds
25-100 µM

What role do Breath-actuated MDIs play in reducing or eliminating?

Hand coordination
Hand-breath coordination (correct)
Breath actuation
Propellant evaporation

What kind of inhaler is an Autohaler?

Manual
Handheld
Nebulizer
Breath-actuated (correct)

How does Respimat transform the aqueous solution in principle?

Into liquid aerosol droplets (D) Signup and view all the answers

What is the main feature of propellant-free MDIs?

Similar to nebulizers in application (B) Signup and view all the answers

What step must patients take prior to inhalation when using an Autohaler?

Lift a lever to prime the device (D) Signup and view all the answers

What is the key difference between ExuberaÔ and AfrezzaÔ in terms of formulation?

ExuberaÔ contains a blister of insulin inserted in the inhaler, while AfrezzaÔ is a dry formulation of human insulin (C) Signup and view all the answers

What sets AfrezzaÔ apart from ExuberaÔ as an inhaler device?

AfrezzaÔ is more portable and less cumbersome than ExuberaÔ (A) Signup and view all the answers

What is the primary advantage of large porous particles over conventional particles in DPIs?

Large porous particles provide faster drug delivery than conventional particles (B) Signup and view all the answers

Which company commercialized ExuberaÔ and later withdrew it from the market?

Pfizer (A) Signup and view all the answers

What makes AfrezzaÔ unique among inhaled insulins?

Portable and not cumbersome (C) Signup and view all the answers

What is the purpose of spacer devices in the context of pMDIs and DPIs?

To assist in drug delivery by improving inhalation technique (D) Signup and view all the answers

Which component of a pressurized metered dose inhaler (pMDI) delivers a specific amount of product with each actuation?

Metering valve (A) Signup and view all the answers

What is the role of surfactants in propellant-containing pMDIs?

To disperse drug particles in suspension (B) Signup and view all the answers

Why are spacer devices important for inhalational techniques involving pMDIs and DPIs?

To ensure proper inhalation technique and drug delivery (B) Signup and view all the answers

What do breath-actuated devices aim to achieve in the context of inhalational techniques?

To deliver drugs upon inhalation without the need for manual actuation (A) Signup and view all the answers

Which component of a pressurized metered dose inhaler (pMDI) provides an orifice for the discharge of spray?

Spray actuator (B) Signup and view all the answers

Which type of inhalation device does not require specific inhalation technique or coordination?

Nebulizers (B) Signup and view all the answers

What is a disadvantage common to both nebulizers and DPIs?

Contain lactose (C) Signup and view all the answers

Which inhalation device has the advantage of being breath-actuated?

Clickhaler Diskhaler® (C) Signup and view all the answers

What is a common disadvantage of pMDIs and DPIs?

Respirable dose depends on inspiratory flow rate (B) Signup and view all the answers

Which inhalation device is known for its sealed environment and reproducible dosing?

pMDIs (D) Signup and view all the answers

What is a common disadvantage of Diskus® and nebulizers?

Non-portable (A) Signup and view all the answers

What is the primary purpose of using a spacer device in respiratory drug delivery?

To reduce the risk of systemic side effects from the drug (A) Signup and view all the answers

Which statement is true regarding reverse flow spacer devices?

They use a bag that collapses upon exhalation (B) Signup and view all the answers

Why do spacer devices reduce the risk of oral candidiasis and dysphonia with inhaled corticosteroids?

By decreasing the amount of drug reaching the throat region (C) Signup and view all the answers

Which drawback is associated with using spacer devices for respiratory drug delivery?

The need for regular cleaning maintenance (D) Signup and view all the answers

What distinguishes a valved holding chamber from a simple tube extension as a spacer device?

The presence of a one-way valve to contain aerosols until inhalation (D) Signup and view all the answers

How do spacer devices help in reducing systemic side effects of inhaled drugs?

By reducing fraction of swallowed drug and subsequent GI absorption (B) Signup and view all the answers

Flashcards

pMDI Particle Size

Particles produced from flashing propellant are approximately 35 µM in size.

Breath-actuated MDI Role

Breath-actuated MDIs help in reducing or eliminating hand-breath coordination issues.