Cardio part 3 Adult Health

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Questions and Answers

In the context of coronary artery disease, which statement best elucidates the pathophysiological distinction between arteriosclerosis and atherosclerosis?

  • Arteriosclerosis is characterized by the infiltration of macrophages into the tunica intima, whereas atherosclerosis involves diffuse medial calcification and subsequent arterial stiffening.
  • Atherosclerosis is a subtype of arteriosclerosis specifically involving the accumulation of lipid-laden plaques within the arterial walls, while arteriosclerosis represents a broader category of arterial hardening from various causes. (correct)
  • Atherosclerosis involves deposition of collagen and elastin in the arterial intima, causing vessel wall thickening, while arteriosclerosis is marked by the formation of foam cells from oxidized LDL cholesterol.
  • Arteriosclerosis primarily affects small arterioles, leading to increased peripheral resistance, whereas atherosclerosis impacts larger elastic arteries, resulting in aortic aneurysms.

A patient presents with exertional chest pain that is promptly relieved by rest. Further diagnostic evaluation reveals the presence of a stable atherosclerotic plaque in the proximal left anterior descending artery. Which underlying mechanism most directly accounts for the alleviation of symptoms with rest?

  • Reduction in myocardial oxygen demand, aligning with the limited oxygen supply available due to the fixed stenosis caused by the stable plaque. (correct)
  • Recruitment of collateral vessels distal to the stenosis, enhancing myocardial perfusion during periods of reduced oxygen demand.
  • Increased circulating levels of endogenous nitric oxide, leading to systemic vasodilation and reduced myocardial oxygen demand.
  • Activation of adenosine receptors in the myocardium, promoting coronary vasodilation and increased oxygen delivery to ischemic tissues.

In the context of acute coronary syndrome, which statement accurately differentiates unstable angina from myocardial infarction concerning their respective impacts on myocardial tissue integrity and the release of cardiac biomarkers?

  • Unstable angina is characterized by transient myocardial ischemia without irreversible damage or significant troponin elevation, whereas myocardial infarction involves necrosis and a measurable troponin increase. (correct)
  • Both unstable angina and myocardial infarction involve irreversible myocardial necrosis, but unstable angina typically presents with a more pronounced elevation in CK-MB levels.
  • Unstable angina results in irreversible myocardial necrosis and a significant elevation in cardiac troponins, whereas myocardial infarction causes transient ischemia without cellular damage or biomarker release.
  • Both unstable angina and myocardial infarction are characterized by similar degrees of myocardial ischemia and necrosis, differing only in the persistence of ST-segment elevation on ECG.

Following percutaneous coronary intervention (PCI) with stent placement, a patient develops acute chest pain accompanied by ST-segment elevation on ECG. Assuming stent thrombosis has occurred, which pathophysiological process is the most likely primary driver of this event?

<p>Disruption of the endothelial layer covering the stent struts, initiating platelet aggregation and thrombus formation. (A)</p> Signup and view all the answers

A patient with known coronary artery disease presents to the emergency department with crushing chest pain radiating down the left arm. An ECG reveals ST-segment elevation in leads II, III, and aVF. Which coronary artery is most likely occluded, based on the ECG findings?

<p>Right coronary artery (RCA) (C)</p> Signup and view all the answers

In the context of Coronary Artery Bypass Grafting (CABG), what is the underlying rationale for utilizing the left internal mammary artery (LIMA) as a conduit for myocardial revascularization, in comparison to saphenous vein grafts?

<p>The LIMA demonstrates superior long-term patency rates, attributable to its structural characteristics and resistance to atherosclerotic changes. (C)</p> Signup and view all the answers

A 68-year-old male with a history of hypertension and hyperlipidemia is diagnosed with stable angina. Medical management is initiated, including beta-blockers, aspirin, and statins. What is the primary mechanism by which beta-blockers alleviate anginal symptoms in this patient population?

<p>Reducing myocardial oxygen demand through decreased heart rate, contractility, and blood pressure. (D)</p> Signup and view all the answers

Following an acute myocardial infarction, a patient develops new-onset mitral regurgitation. Which underlying mechanism most likely accounts for this complication in the context of ischemic heart disease?

<p>Papillary muscle rupture or dysfunction secondary to ischemia, resulting in impaired mitral valve leaflet coaptation. (A)</p> Signup and view all the answers

A patient undergoing thrombolytic therapy for acute ST-elevation myocardial infarction (STEMI) develops a sudden, severe headache, accompanied by neurological deficits. Which complication should be suspected, and what is the most appropriate immediate intervention?

<p>Intracranial hemorrhage; immediately discontinue thrombolytic therapy and obtain a CT scan of the head. (A)</p> Signup and view all the answers

In managing a patient with acute decompensated heart failure, which hemodynamic parameter best reflects the degree of left ventricular preload and guides diuretic therapy?

<p>Pulmonary artery wedge pressure (PAWP) (D)</p> Signup and view all the answers

A 72-year-old female presents with increasing dyspnea, orthopnea, and paroxysmal nocturnal dyspnea. Physical examination reveals jugular venous distension, bilateral lower extremity edema, and an S3 gallop. Which underlying pathophysiological mechanism is primarily responsible for the development of these clinical findings?

<p>Impaired left ventricular systolic function resulting in elevated left ventricular end-diastolic pressure and pulmonary congestion. (C)</p> Signup and view all the answers

Among patients with heart failure and reduced ejection fraction (HFrEF), which neurohormonal pathway is targeted by angiotensin-converting enzyme (ACE) inhibitors to improve cardiac remodeling and clinical outcomes?

<p>The renin-angiotensin-aldosterone system (RAAS), resulting in decreased sodium and water retention and reduced ventricular hypertrophy. (D)</p> Signup and view all the answers

A patient with chronic heart failure is prescribed digoxin. Which electrophysiological effect of digoxin on the cardiac conduction system necessitates careful monitoring for potential drug-induced arrhythmias?

<p>Depression of the sinoatrial (SA) node automaticity and slowed AV nodal conduction. (B)</p> Signup and view all the answers

A patient with decompensated heart failure is receiving intravenous furosemide. What electrolyte abnormalities are most likely to be exacerbated by this loop diuretic, necessitating vigilant monitoring and potential replacement therapy?

<p>Hypokalemia and hypomagnesemia (B)</p> Signup and view all the answers

A patient presents with acute pulmonary edema secondary to left ventricular systolic dysfunction. What is the primary mechanism by which intravenous morphine alleviates dyspnea in this clinical scenario?

<p>Reduced systemic vascular resistance and preload, decreasing pulmonary capillary wedge pressure. (C)</p> Signup and view all the answers

In the management of chronic heart failure, which dietary modification most effectively mitigates fluid retention and reduces the risk of recurrent decompensation?

<p>Strict sodium restriction to reduce intravascular volume expansion. (C)</p> Signup and view all the answers

A patient with right-sided heart failure exhibits prominent jugular venous distension (JVD). Which pathophysiological mechanism directly contributes to this clinical sign?

<p>Elevated central venous pressure due to impaired right ventricular filling and increased systemic venous congestion. (A)</p> Signup and view all the answers

In the context of advanced heart failure management, what is the primary rationale for using human B-type natriuretic peptide (nesiritide) in select patients?

<p>To promote vasodilation and reduce both preload and afterload. (B)</p> Signup and view all the answers

In the context of fluid balance considerations in heart failure, what is the physiological basis for the recommendation to restrict daily fluid intake?

<p>To reduce intravascular volume overload and alleviate pulmonary congestion. (B)</p> Signup and view all the answers

A patient with advanced heart failure is being considered for cardiac transplantation. Which absolute contraindication would preclude the patient from being a suitable candidate for this intervention?

<p>Active systemic infection or irreversible end-organ damage. (C)</p> Signup and view all the answers

Which diagnostic modality offers the most comprehensive assessment of cardiac structure, function, and hemodynamics in patients with heart failure, enabling the differentiation between systolic and diastolic dysfunction?

<p>Echocardiogram (D)</p> Signup and view all the answers

What is the clinical significance of elevated levels of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in patients with acute and chronic heart failure?

<p>Reflects the degree of ventricular stretch and volume overload, correlating with the severity of heart failure. (C)</p> Signup and view all the answers

A patient experiencing an acute exacerbation of heart failure is prescribed oxygen therapy. What constitutes the primary goal of oxygen administration in this clinical context?

<p>To increase PaO2 and improve oxygen delivery to peripheral tissues. (D)</p> Signup and view all the answers

Following discharge after hospitalization for heart failure, what specific instructions should be emphasized to patients regarding daily weight monitoring to facilitate early detection of fluid retention?

<p>Weigh themselves daily at the same time, using the same scale, and wearing similar clothing to ensure consistency. (D)</p> Signup and view all the answers

Flashcards

Arteriosclerosis

Thickening or hardening of the arteries, restricting blood flow and reducing arteries' ability to expand.

Atherosclerosis

A type of arteriosclerosis, plaque builds up inside the arteries (fatty substances, cholesterol, cellular waste).

Coronary Heart Disease

Coronary artery disease with symptoms, such as chest pain (angina).

Ischemic Heart Disease

Resulting from insufficient blood supply to the heart muscle (ischemia), often due to plaque buildup or blood clot obstruction.

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Angina Pectoris

Chest pain or discomfort due to myocardial ischemia (inadequate oxygen supply to the heart muscle).

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Myocardial Infarction

Heart attack, resulting from prolonged ischemia leading to irreversible damage to the heart muscle.

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Sudden Cardiac Death

Abrupt loss of heart function, breathing, and consciousness.

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ST Elevation

A diagnostic indicator where the ST segment on the EKG does not return to the baseline, potentially indicating a myocardial infarction.

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Cardiac Biomarkers

Blood tests that measure cardiac enzymes and proteins released when the heart muscle is damaged.

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Echocardiogram

Ultrasound of the heart used to assess its structure and function, revealing abnormalities such as cardiomyopathy.

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Heart Catheterization

Invasive procedure using a catheter to visualize the coronary arteries and identify blockages.

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Exercise Stress Test

Involves monitoring EKG and blood pressure while the patient walks on a treadmill or cycles.

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Nitroglycerin

Vasodilator that increases blood flow to the heart and decreases the heart's workload.

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Nitroglycerin Dosage

Administer one dose, wait five minutes, check blood pressure, and repeat up to three doses if blood pressure remains stable and chest pain persists.

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Aspirin Use

Commonly administered to prevent further clot formation. (Given as either an 81 mg or a 325 mg upon arrival at the emergency room)

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PTCA/PCI

Involves inserting a catheter into the narrowed part of the artery to compress plaque and increase blood flow, with possible stent placement.

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CABG

Bypassing blocked sections of the coronary artery by placing grafts above and below the obstruction to restore blood flow.

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ABCs

Prioritize Airway, Breathing, and Circulation.

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Myocardial Infarction (MI)

The official name of a heart attack. Occurs when one or more coronary artery branches become blocked, leading to the death (infarction) of heart tissue

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Unstable Angina

Changes in frequency, severity, or duration indicate an increased risk of MI.

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Goal of PCI Performance

Performed within 60 minutes of arrival at the hospital

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Thrombolytics

Clot-busting drugs used for reperfusion and must be infused within 6 hours of chest pain onset.

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Oxygen Administration

Administer if oxygen saturation is less than 91%.

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PCI (Percutaneous Coronary Intervention)

Also known as PTCA (Percutaneous Transluminal Coronary Angioplasty) involving femoral, radial, or brachial artery for access.

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MONA

Morphine, Oxygen, Nitroglycerin, and Aspirin for the initial treatment of MI.

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Study Notes

  • Coronary Artery Disease (CAD) is a cardiovascular disorder and the leading cause of death in the United States.
  • CAD involves the narrowing or blockage of coronary arteries, affecting blood supply to the heart muscle.
  • Key aspects of CAD include mechanisms, risk factors, symptoms, and management strategies.

Arteriosclerosis

  • Arteriosclerosis is the thickening or hardening of the arteries, restricting blood flow.
  • Arteriosclerosis reduces the ability of arteries to expand, leading to decreased blood flow.

Atherosclerosis

  • Atherosclerosis is a type of arteriosclerosis.
  • It involves plaque buildup inside the arteries, composed of fatty substances, cholesterol, cellular waste, calcium, etc.
  • Atherosclerosis is the more prevalent condition compared to arteriosclerosis.

Coronary Heart Disease

  • Coronary Heart Disease is the presence of coronary artery disease with symptoms like chest pain (angina).

Ischemic Heart Disease

  • Ischemic Heart Disease results from insufficient blood supply (ischemia) to the heart muscle.
  • Ischemic Heart Disease is often due to plaque buildup or blood clot obstruction in coronary arteries.
  • The heart requires a constant supply of oxygen-rich blood to function properly.

Prevention

  • Adopting and maintaining healthy habits is crucial for preventing CAD.
  • Diet should avoid high-fat foods that contribute to CAD.
  • Abstaining from smoking is essential.
  • Plaque buildup is cumulative, with existing plaque remaining despite healthier habits.
  • Regular physical activity helps maintain cardiovascular health
  • Managing high cholesterol (hyperlipidemia) is important.

Asymptomatic CAD

  • Plaque buildup can occur without noticeable symptoms

Angina Pectoris

  • Angina Pectoris is chest pain/discomfort due to myocardial ischemia.
  • Angina Pectoris occurs when myocardial oxygen demand exceeds supply.
  • Angina Pectoris is often used interchangeably with chest pain.
  • Angina is traditionally a chronic condition but can become acute.
  • Stable Angina is pain that stops after activity ceases, while Unstable Angina has increased frequency/severity, not relieved by rest/nitroglycerin.

Precipitating Factors of Angina

  • Atherosclerosis (plaque buildup)
  • Coronary artery spasm
  • Exertion or exercise
  • Emotional stress
  • Eating a large meal
  • Cold weather
  • Circadian rhythms (early morning)

Assessment of Angina

  • Pain Level ranges from mild to excruciating.
  • Location is typically substernal.
  • Description includes pressure, burning, squeezing, or fullness.
  • Radiation may extend to the neck, jaw, and left arm
  • Associated Symptoms: mild indigestion, shortness of breath, nausea, vomiting, diaphoresis, dizziness

Angina Gender Differences

  • Women present with different symptoms like nausea, vomiting, fatigue, indigestion, upper back pain, or abdominal discomfort.

Myocardial Infarction

  • Myocardial Infarction is a heart attack resulting from prolonged ischemia.
  • Myocardial Infarction leads to irreversible damage to the heart muscle.

Sudden Cardiac Death

  • Sudden Cardiac Death is an abrupt loss of heart function, breathing, and consciousness.

Electrocardiogram (EKG)

  • EKGs detect abnormalities in the heart's electrical activity.
  • ST Elevation is a significant diagnostic indicator
  • Normal EKG shows typical P, QRS, and T waves, with the ST segment returning to baseline.
  • ST Elevation EKG occurs when the ST segment remains elevated instead of returning to baseline before the T wave.

Cardiac Biomarkers

  • Cardiac Biomarkers are blood tests that measure cardiac enzymes and proteins released when the heart muscle is damaged.
  • Elevated levels of cardiac biomarkers indicate myocardial infarction.

Echocardiogram

  • Echocardiograms involve ultrasound to assess the heart's structure and function.
  • Echocardiograms can reveal abnormalities like cardiomyopathy.

Heart Catheterization (Cardiac Cath)

  • Heart Catheterization visualizes the coronary arteries and identify blockages.
  • Heart Catheterization involves inserting a catheter into a blood vessel to inject contrast dye and take X-rays.

Exercise Stress Test

  • Exercise Stress Tests evaluate heart function during physical activity.
  • Exercise Stress Test involves monitoring EKG and blood pressure while the patient walks on a treadmill or cycles.

Clinical Signs of CAD

  • Patients may appear cold and clammy, ashen in color.
  • There may be shortness of breath and weakness.
  • Vital signs (blood pressure and pulse) may be elevated due to pain
  • Nature: Symptoms may come and go,
  • Relief: may be relieved by changes in activity or nitroglycerin.

Complete Workup for Angina

  • This includes vital signs monitoring, EKG, stress test, and cardiac biomarkers.

Medications for Angina

  • Nitroglycerin is a vasodilator that increases blood flow to the heart and decreases its workload.
  • Nitroglycerin is administered sublingually for rapid absorption.
  • Monitor blood pressure before administering subsequent doses of Nitroglycerin, and wait five minutes between doses, as it can cause a hypotensive effect..
  • Heparin may be administered if a blood clot is suspected.
  • Aspirin is commonly administered to prevent further clot formation.

Aspirin Administration

  • Patients arriving at the ER may be given either an 81 mg or a 325 mg aspirin.

Medication Review

  • Be aware that the patient might already be on medications such as Plavix, calcium channel blockers, or beta blockers.
  • Caution should be exercised, as calcium channel blockers and beta blockers can decrease heart rate and blood pressure.
  • It is crucial to check these parameters before administering any additional medications.

Morphine for Pain

  • Morphine, an opioid, may be administered for pain relief and can decrease respiratory rate.
  • Ensure the patient's respiratory rate is within normal limits before administering morphine.

Invasive Interventions

  • Consent forms are required for all invasive procedures.

Percutaneous Transluminal Coronary Angioplasty or Percutaneous Coronary Intervention (PTCA/PCI)

  • Percutaneous Transluminal Coronary Angioplasty involves inserting a catheter into the narrowed part of the artery.

  • A balloon is inflated to compress the plaque against the artery walls, increasing blood flow.

  • A stent may be placed to maintain vessel patency.

  • Patients with stents require anti-coagulants for at least three months, possibly longer.

  • The patient is typically sedated but awake during the procedure, which lasts about one to two hours.

Coronary Artery Bypass Graft (CABG)

  • Coronary Artery Bypass Graft involves bypassing blocked sections of the coronary artery.
  • Grafts are placed above and below the obstruction to restore blood flow to the heart.

Nursing Interventions for Acute Angina

  • Prioritize Airway, Breathing, and Circulation (ABCs).
  • Comfort: Ensure patient comfort and promote rest in a calm environment.
  • Pain Management: Treat pain and anxiety with appropriate medications (including nitroglycerin).
  • Diet: Provide small, frequent meals to avoid triggering chest pain
  • Activity: Balance rest periods with activity.
  • Prophylactic Nitroglycerin: May be prescribed for patients with chronic angina before activities like exercise and sexual activity.
  • Education: Explain all procedures/medications, addressing patient questions/concerns about angina
  • Monitoring: Administer medications, monitor vital signs, and assess respiratory and cardiac systems
  • Psychosocial Support: Allow patients to verbalize their concerns/feelings to decrease anxiety.
  • Timing of Education: Educate the client when they are ready and stable; avoid during acute chest pain.
  • Action During Symptoms: Teach patients to immediately stop activity if chest pain, dyspnea, syncope, or vertigo occurs.

Patient Teaching: Lifestyle Modifications

  • Dietary Advice: Avoid heavy, large meals.
  • Rest: Rest for one to two hours after meals.
  • Environmental Factors: Avoid extremes in temperature.
  • Substance Use: no caffeine or tobacco.
  • Nitroglycerin Use: Take nitroglycerin prior to activities that may trigger angina. Keep nitroglycerin with the patient at all times. Replace nitroglycerin ever 3-6 months.

Additional Patient Education Points

  • Nitroglycerin Sensations: A burning sensation indicates that the nitroglycerin is working.
  • Nitroglycerin Side Effects: Nitroglycerin can cause headaches and flushing.
  • Drug Interactions: Nitroglycerin should not be taken with erectile dysfunction medications due to the risk of severe hypotension.

Myocardial Infarction

  • Definition: Commonly known as a heart attack, caused by blockage of a coronary artery branch.
  • Process: Blockage can cause ishemia and chest pain, and can lead to tissue death.
  • Severity Factors: Location and size of blockage, and presence of collateral circulation.

Collateral Circulation

  • Definition: New blood vessels that bypass a blockage.
  • Impact: Can mean fewer signs and symptoms for patients.
  • Time Sensitivity: Time to emergency room is critical.
  • MI Symptoms: More sever and long lasting than angina.

Unstable Angina

  • Angina that changes in frequency, severity, or duration, indicates an increased risk of MI.
  • Location of Mi: The location of the heart attack effects the severity and type of complications.

Anterior MI

  • Affects the front of the heart and can cause severe issues due to its impact on the left ventricle.

Left Ventricle

  • The primary pumping chamber of the heart, crucial for systemic circulation.

Rapid assessment

  • Rapid assessment is essential for a timely intervention

Peak time

  • Peak time for a heart attack is between 6:00am and 12:00pm noon due to circadian rhythm

Seasonal influence

  • There is a seasonal influence, heart attacks are more common in winter months

Classic symptoms

  • Severe, sudden, pressure-like chest pain that increases over time and radiation
  • Sensation of squeezing or heavy weight on the chest
  • Pain Radiating to the left arm, jaw, neck or teeth

Atypical symptoms

  • Gastrointestinal (GI) symptoms instead of chest pain

Objective signs

  • Pallor, erratic behavior, hypotension, shock
  • Cardiac rhythm changes, vomiting, fever, diaphoresis

Pain Characteristics

  • Location: Retrosternal or substernal chest pain
  • Radiation: Radiates down the left arm, to the neck, jaw, and teeth

Women differences

  • Women may experience different symptoms than men
  • Common symptoms include unusual fatigue, sleep disturbances, and shortness of breath

Rapid Pulse & Weak Pulse

  • Indicates compromised cardiac function

Blood Pressure Changes

  • Blood pressure changes are initially elevated due to catecholamine release
  • Can drop as cardiac output decreases

Nausea and Vomiting

  • Common in inferior MI

Diagnostic studies

  • Diagnostic studies include a 12-lead EKG, cardiac biomarkers, electrolyte levels, and cardiac catheterization.
  • 12 Lead ECG should be performed within 10 minutes of arrival to the emergency room

Cardiac Biomarkers

  • CK-MB: Specific for heart muscle damage.
  • LDH: Indicates tissue damage.
  • Troponin 1: The best indicator of myocardial infarction, cardiac-specific.

STEMI & NON-STEMI

  • Understanding the difference between STEMI and NSTEMI is crucial for appropriate treatment
  • Initial Treatment focuses on relieving pain, providing oxygen, and preventing further clot formation

Oxygen administration

  • Administer Oxygen is at saturation is less than 91%
  • Administer medication as soon as a patient starts to complaint about pain

Beta Blockers and Calcium Channel Blockers

  • Can be administered to reduce heart rate and blood pressue

Reperfusion Strategies

  • Reperfusion Strategies aim to restore blood flow to the heart muscle
  • Percutaneous conronary intervention (PCI) is preferred but thrombolytics are used if PCI is not available

PCI

  • PCI also know as PTCA (Percutaneous Transluminal Coronary Angioplasty)

Thrambolytics

  • Thrombolytics are clot busting drugs for reperusion
  • Thrombolytics must be infused within 6 hours of chest pain onset

Nursing interventions

  • Nurses interventions inlcude monitoring vital signs and ensuring bed rest

Initial Recovery Phase

  • Description: Administering prescribe medication
  • Continuous cardiac monotoring and long periods of undisturbed rest

Dietary managemnet

  • Description: Dietary perogression and support healing and prevent further cadiac event
  • Initially patients are NPO (nothing by mouth) in case of procedures

Medication Management

  • Lipid-lowing medications are often prescribed for the rest of the patients life
  • Asses respiratory and cardiac intervention and strict intake and output ( I&O) monitoring

Nursing interventions and Health promotion

  • Description: Key nursing actions and health promotion strategies for MI patients
  • Review nursing interventions

Heart Failure

  • Heart failure is a chronic condition resulting from structural and functional cardiac issue
  • Can be caused by atrial fibrilation and a Complication by underlying heart disease
  • Cardiac output is insufficient to meet the bodies needs due to the hearts inability to pump blood effectively

Preload and afterload

  • Preload: The stretch or filling of the heart
  • Afterload: The resistance the heart must overcome to eject blood

Right-Sided Heart Failure

  • Right-sided heart failure occurs when the right ventricle cannot effectively pump blood into the pulmonary circulation and leading to systemic congestion

Left-Sided Heart Failure

  • Left-sided heart failure occurs when the left ventricle cannot effectively pump blood into the systemic circulation and leading to pulmonary congestion.
  • Assess symptoms: Shortness of breath and edema
  • Prevent progression and compilations: early detection and intervention is key
  • Positioning: high fowlers postition to breath

Dietary Management in Heart Failure

  • Mild heart failure 2- gram sodium diet
  • Severe heart failure: as low as 500 mg sodium diet
  • Fluid Restriction: May be necessary to control edema and lund congestion

Patient Education

  • Educating patients about self-management is essential for improving outcomes and preventing hospital reanimissions
  • Daily Weight Monitoring: Same time and clothes

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