COPD and Bacterial Infections Quiz
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Questions and Answers

What is a common viral infection involved in exacerbations of COPD?

  • Rhinovirus (correct)
  • Influenza A virus
  • Varicella-zoster virus
  • Hepatitis B virus
  • Why can bacteria proliferate and persist in COPD airways?

  • Defective innate immune responses (correct)
  • Excessive oxygen levels
  • Overactive alveolar macrophages
  • Lack of nutrients in the airways
  • Which of the following is NOT an associated feature of systemic inflammation in COPD?

  • Nutritional abnormalities
  • Weight loss
  • Improved lung function (correct)
  • Skeletal muscle dysfunction
  • Why is persistent systemic inflammation considered a novel phenotype in COPD?

    <p>It is linked to poor clinical outcomes</p> Signup and view all the answers

    What percentage of patients with COPD show some components of systemic inflammation?

    <p>70%</p> Signup and view all the answers

    What can lead to bacterial exacerbation in COPD?

    <p>Both airway and systemic inflammation</p> Signup and view all the answers

    What are the common manifestations of chronic inflammation in chronic obstructive pulmonary disease (COPD)?

    <p>Decreased lung elastic recoil and structural changes</p> Signup and view all the answers

    Which physiological change is associated with COPD?

    <p>Loss of small airway patency leading to air trapping</p> Signup and view all the answers

    What effect does alveolar destruction have on gas exchange in COPD?

    <p>Reduces the efficiency of gas exchange</p> Signup and view all the answers

    Which lung pathology is characterized by premature closure of airways on expiration?

    <p>Obstructive bronchiolitis</p> Signup and view all the answers

    What contributes to the inefficient mixing of inspired air in COPD?

    <p>Increased residual volume</p> Signup and view all the answers

    Which event is NOT a result of chronic inflammation in COPD?

    <p>Enhanced lung elastic recoil</p> Signup and view all the answers

    What is considered the hallmark of COPD?

    <p>Increased neutrophils in airways inflammation</p> Signup and view all the answers

    Which cell type is important in the pathogenesis of COPD due to their elevated levels in sputum and bronchoalveolar lavage fluid?

    <p>Macrophages</p> Signup and view all the answers

    What is a characteristic feature of alveolar macrophages from COPD patients?

    <p>Enhanced elastase activity compared to healthy controls</p> Signup and view all the answers

    In what percentage of COPD patients is eosinophilic inflammation found?

    <p>15-40%</p> Signup and view all the answers

    What is the role of eosinophils in COPD pathogenesis?

    <p>Play an important role in eosinophilic inflammation</p> Signup and view all the answers

    What percentage of patients with stable COPD experience bacterial infection?

    <p>30%</p> Signup and view all the answers

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