10 Questions
What is one of the pathophysiologic explanations for allergic-like hypersensitivity reactions?
Activation of the contact and complement systems
What is a benefit of premedication according to the text?
Reduction of immediate adverse events from high-osmolality contrast media
Which type of contrast media is generally associated with less adverse events according to the text?
Low-osmolality nonionic monomers
Which type of patient population was NOT studied in the randomized trials of premedication?
High-risk patients
What influence does hyperosmolality of the contrast medium have on the likelihood of contrast reactions?
Stimulation of histamine release from basophils and mast cells
What is the estimated number needed to premedicate to prevent one severe reaction in high-risk patients?
569
Which type of contrast media is generally associated with a reduced likelihood of physiologic reactions following intravenous administration?
Low-osmolality nonionic monomers
What is the potential benefit of premedication for average-risk patients prior to high-osmolality iodinated contrast medium administration?
Reducing the likelihood of immediate adverse events
What do many experts believe about the efficacy of premedication in high-risk patients receiving low-osmolality iodinated contrast medium?
Premedication reduces the likelihood of a reaction
What was one limitation of the randomized trials of premedication discussed in the text?
Inconclusive results on the effect of premedication in high-risk patients
Test your knowledge on predicting adverse reactions with intradermal skin testing, corticosteroid premedication, and the etiology of hypersensitivity contrast reactions. Explore the mechanisms behind immediate hypersensitivity contrast reactions.
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