Podcast
Questions and Answers
What should patients be advised to do in the event of sudden loss of hearing?
What should patients be advised to do in the event of sudden loss of hearing?
- Stop taking TALEGRIA and wait for further instructions
- Seek prompt medical attention (correct)
- Continue taking TALEGRIA as usual
- Take an additional dose of TALEGRIA
Why is once-a-day dosing of tadalafil not recommended in patients with severe renal impairment?
Why is once-a-day dosing of tadalafil not recommended in patients with severe renal impairment?
- Because of increased tadalafil exposure (correct)
- Because of unchanged tadalafil exposure
- Because of unpredictable tadalafil exposure
- Because of decreased tadalafil exposure
What should patients do if they experience erections lasting 4 hours or more?
What should patients do if they experience erections lasting 4 hours or more?
- Try to resolve it through self-medication
- Wait for a few more hours to see if it resolves on its own
- Take an additional dose of TALEGRIA
- Seek immediate medical assistance (correct)
Why should TALEGRIA be used with caution in patients with anatomical deformation of the penis?
Why should TALEGRIA be used with caution in patients with anatomical deformation of the penis?
What should patients avoid taking in combination with TALEGRIA?
What should patients avoid taking in combination with TALEGRIA?
Why should patients with rare hereditary problems of galactose intolerance not take TALEGRIA?
Why should patients with rare hereditary problems of galactose intolerance not take TALEGRIA?
In which patients is the use of TALEGRIA not recommended?
In which patients is the use of TALEGRIA not recommended?
What should patients be advised to do if they experience symptoms upon initiation of sexual activity?
What should patients be advised to do if they experience symptoms upon initiation of sexual activity?
What is a cause of decreased vision, including permanent loss of vision, associated with TALEGRIA?
What is a cause of decreased vision, including permanent loss of vision, associated with TALEGRIA?
What should patients be advised to do if they experience sudden visual defects while taking TALEGRIA?
What should patients be advised to do if they experience sudden visual defects while taking TALEGRIA?
What is a reported adverse effect of tadalafil?
What is a reported adverse effect of tadalafil?
Who are at increased risk of NAION?
Who are at increased risk of NAION?
Study Notes
Contraindications
- myocardial infarction within the last 90 days
- unstable angina or angina during sexual intercourse
- New York Heart Association Class 2 or greater heart failure in the last 6 months
- uncontrolled dysrhythmia, hypotension (< 90/50 mm Hg), or uncontrolled hypertension
- stroke within the last 6 months
Warnings
- patients who experience symptoms upon initiation of sexual activity should refrain from further activity and report to their medical practitioner
- sudden visual defects, including permanent loss of vision, have been reported in connection with TALEGRIA and other PDE5 inhibitors
- increased risk of acute NAION (non-arteritic anterior ischaemic optic neuropathy) in men with erectile dysfunction
- patients who have already experienced NAION are at increased risk of NAION
Adverse Reactions
- cases of sudden hearing loss have been reported after the use of tadalafil
- patients should stop taking TALEGRIA and seek prompt medical attention in the event of sudden decrease or loss of hearing
- events may be accompanied by tinnitus and dizziness
Special Populations
- once-a-day dosing of tadalafil is not recommended in patients with severe renal impairment
- once-a-day administration has not been evaluated in patients with hepatic insufficiency
- caution should be exercised in patients with anatomical deformation of the penis or conditions that may predispose them to priapism
Interactions
- caution should be exercised when prescribing TALEGRIA to patients using potent CYP3A4 inhibitors (ritonavir, saquinavir, ketoconazole, itraconazole, and erythromycin)
- increased tadalafil exposure (AUC) has been observed when combined with potent CYP3A4 inhibitors
Other
- patients should be informed not to take TALEGRIA in combination with other PDE5 inhibitors or treatments for erectile dysfunction
- patients with rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption should not take TALEGRIA
- TALEGRIA contains less than 1 mmol sodium (23 mg) per tablet, making it essentially sodium-free
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Description
This quiz covers the patient groups in which the use of TALEGRIA is not recommended. It includes patients with recent myocardial infarction, unstable angina, and heart failure, among others.
