Connective Tissue Overview and Components

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Questions and Answers

What is the primary function of fibrocartilage?

  • Acts as a shock absorber in joints (correct)
  • Provides a smooth surface for joint movement
  • Supports the respiratory system
  • Facilitates nutrient absorption

Which type of growth occurs from the perichondrium in cartilage?

  • Appositional growth (correct)
  • Endochondral growth
  • Hypertrophic growth
  • Interstitial growth

What is the primary role of osteoblasts in bone formation?

  • Remove old bone tissue
  • Maintain calcium balance in the blood
  • Transport nutrients to bone cells
  • Produce collagen and mineralized ground substance (correct)

Which component constitutes the highest percentage of bone's inorganic material?

<p>Calcium phosphate (A)</p> Signup and view all the answers

What characterizes osteoclasts and their function in bone?

<p>They play a role in bone resorption and remodeling. (C)</p> Signup and view all the answers

What is the primary function of collagen fibers in connective tissue?

<p>To provide support and structure to tissues (A)</p> Signup and view all the answers

Which type of lymphocyte is responsible for producing plasma cells that secrete antibodies?

<p>B lymphocytes (B)</p> Signup and view all the answers

What is the main component of the ground substance in connective tissue?

<p>Glycosaminoglycans and proteoglycans (A)</p> Signup and view all the answers

Which type of fiber is known for providing flexibility and the ability to return to its original shape after stretching?

<p>Elastic fibers (A)</p> Signup and view all the answers

What distinguishes reticular fibers from collagen fibers?

<p>Reticular fibers are shorter and thinner (B)</p> Signup and view all the answers

What is the primary function of connective tissue in the body?

<p>Forming a structural framework (A)</p> Signup and view all the answers

Which type of connective tissue is primarily responsible for energy storage?

<p>Adipose tissue (C)</p> Signup and view all the answers

Which fixed cell type is most common in connective tissue and is involved in the synthesis of fibers?

<p>Fibroblast (A)</p> Signup and view all the answers

What role do macrophages play in connective tissue?

<p>Ingesting foreign matter and bacteria (A)</p> Signup and view all the answers

Which of the following is NOT a function of connective tissue?

<p>Electrolyte balance (A)</p> Signup and view all the answers

What type of wandering cell in connective tissue serves as a defense mechanism against microorganisms?

<p>Lymphocyte (C)</p> Signup and view all the answers

Which component of the extracellular matrix provides structural support in connective tissues?

<p>Collagen fibers (A)</p> Signup and view all the answers

What is the primary role of mast cells in connective tissue?

<p>Releasing chemical signals during defense responses (A)</p> Signup and view all the answers

What is the primary characteristic of mesenchyme tissue?

<p>It contains abundant extracellular matrix. (B)</p> Signup and view all the answers

Which type of connective tissue is primarily known for its insulation and energy storage?

<p>Adipose tissue (A)</p> Signup and view all the answers

How does brown adipose tissue primarily function in the body?

<p>To generate body heat. (D)</p> Signup and view all the answers

Which of the following is considered a specialized connective tissue?

<p>Blood (C)</p> Signup and view all the answers

What is a key feature of loose areolar connective tissue?

<p>Loosely packed fibers with abundant ground substance (C)</p> Signup and view all the answers

What characteristic distinguishes yellow (white) adipose tissue from brown adipose tissue?

<p>It contains a single large fat droplet. (D)</p> Signup and view all the answers

In terms of development, what do the endoderm, mesoderm, and ectoderm represent?

<p>The three germ layers in embryogenesis. (A)</p> Signup and view all the answers

What process modifies the ground substance in skeletal tissue?

<p>Mineralization through calcium salt deposition (C)</p> Signup and view all the answers

What is the primary component of the bone matrix that provides strength?

<p>Mineralized osteoid (B)</p> Signup and view all the answers

Which type of bone is characterized by being densely packed with few gaps?

<p>Compact bone (C)</p> Signup and view all the answers

What is the correct sequence of cell differentiation during intramembranous ossification?

<p>Osteoprogenitor - Osteoblast - Osteocytes (B)</p> Signup and view all the answers

Which component of blood is responsible for the transportation of oxygen?

<p>Erythrocytes (A)</p> Signup and view all the answers

What percentage of blood plasma is water?

<p>90-92% (A)</p> Signup and view all the answers

What structural change occurs in tendons and ligaments with aging?

<p>They become less flexible and more fragile (A)</p> Signup and view all the answers

What condition results from a deficiency of collagen type III?

<p>Ehlers-Danlos syndrome (C)</p> Signup and view all the answers

What primary function does blood serve besides transportation?

<p>Prevention of diseases and infections (C)</p> Signup and view all the answers

What distinguishes dense regular connective tissue from dense irregular connective tissue?

<p>Dense regular connective tissue has parallel fiber orientation. (C)</p> Signup and view all the answers

What type of cartilage is most abundant and characterized as flexible yet tough?

<p>Hyaline cartilage (A)</p> Signup and view all the answers

Which of the following best describes the primary structure of cartilage?

<p>Composed of specialized cells called chondrocytes. (A)</p> Signup and view all the answers

What function does cartilage primarily serve in joints?

<p>Acts as a shock absorber. (D)</p> Signup and view all the answers

Which type of dense connective tissue contains a greater need for oxygen due to its high capillary density?

<p>Dense irregular connective tissue (A)</p> Signup and view all the answers

Which tissue type is primarily found in regions providing protection, such as the dermis?

<p>Dense irregular connective tissue (A)</p> Signup and view all the answers

Chondrocytes are located within cavities called what?

<p>Lacunae (A)</p> Signup and view all the answers

What primarily makes up the extracellular matrix of cartilage?

<p>Proteoglycans and collagen fibers (B)</p> Signup and view all the answers

Flashcards

Lymphocytes

White blood cells that play a crucial role in the immune system. They are responsible for recognizing and destroying foreign invaders like bacteria and viruses.

Plasma Cells

Specialized B lymphocytes that produce and secrete antibodies, proteins that bind to and neutralize specific pathogens.

Collagen Fibers

The most common type of protein fiber in connective tissue, providing strength and support. They are also important for tissue repair.

Reticular Fibers

Fine, branching collagen fibers that provide support to delicate tissues like the spleen and lymph nodes.

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Elastic Fibers

Fibers that allow tissues to stretch and return to their original shape. They are found in organs like the lungs and skin.

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Fibrocartilage

A strong, tough cartilage type with dense collagen bundles and scattered chondrocytes. It lacks a perichondrium and is found in structures like intervertebral discs, menisci, and the pubic symphysis.

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Elastic Cartilage

A flexible cartilage type with chondrocytes embedded in a thread-like network containing mostly elastic fibers. It provides support and flexibility in structures like the nose, ear, and epiglottis.

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Appositional Growth

Cartilage growth occurs from the outer layer (perichondrium), adding new cartilage layers.

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Interstitial Growth

Cartilage growth occurs from within, as chondrocytes divide and secrete new matrix.

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Bone Functions

Bone performs multiple functions: support, protection, movement, mineral storage, and blood cell production.

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Fluid & Diffusion in Connective Tissue

Connective tissue fluid allows for easy movement of nutrients and waste products (metabolites) throughout the tissue.

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Ground Substance: Solid, Semisolid, Liquid

The ground substance of connective tissue can vary in consistency, ranging from solid (like bone) to semisolid (like cartilage) to liquid (like blood).

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Specialized Connective Tissue

Connective tissue types with unique structures and functions, such as blood, bone, and cartilage.

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Embryonic Connective Tissue: Mesenchyme

Mesenchyme is the precursor to all connective tissues, consisting of fibroblasts and abundant extracellular matrix. It forms during the 3rd and 4th weeks of development.

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Germ Layers: Endoderm

The innermost layer of embryonic tissue. It forms the lining of the digestive tract and its derivatives.

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Germ Layers: Mesoderm

The middle layer of embryonic tissue. It gives rise to muscle, bone, blood vessels, connective tissues, and other structures.

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Germ Layers: Ectoderm

The outermost layer of embryonic tissue. It develops into skin and the nervous system.

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Adult Connective Tissue

The diverse forms of connective tissue found in adults, such as loose connective tissue, dense connective tissue, cartilage, bone, and blood.

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What is Osteoid?

The specific ground substance of bone, strengthened by the deposition of calcium ions (Ca2+).

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What are the main types of fibers found in bone matrix?

Collagen fibers, specifically types I and V, form the majority of the matrix.

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Compact bone

Densely packed bone tissue with few gaps, forming the hard outer layer of bones.

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Spongy bone

Loosely packed bone tissue with many gaps, making up the majority of the interior of most bones.

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Intramembranous ossification

Bone formation that occurs directly within a vascularized membrane, primarily in areas like the skull and face.

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Endochondrial ossification

Bone formation that starts with a cartilage template and later differentiates into osteoblasts, common for long bones.

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What is Blood?

A specialized connective tissue with no fibers, a highly fluid ground substance, and mobile cells.

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What are the main components of blood?

Blood consists of cells (RBC, WBC, platelets) and ground substance (plasma), which is primarily water and proteins.

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Connective Tissue Function

Provides structural support, transports substances, defends the body, stores energy, connects tissues, supports movement, stores substances, cushions and insulates, protects delicate organs.

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Components of Connective Tissues

Connective tissues are made up of cells embedded in an extracellular matrix. The matrix consists of fibers and ground substance (a combination of fluid and chemical substances).

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Fibroblast

The most common cell type in connective tissue, responsible for synthesizing and excreting fibers that form the extracellular matrix.

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Macrophage

A type of cell that ingests foreign matter and bacteria, playing an important role in the immune system.

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Adipocytes

Fat cells that store lipids (fats) in loose connective tissue.

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Mast Cell

Large secretory cells that release chemical signals (mediators) to trigger physiological defense responses, such as inflammation.

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Fixed vs. Wandering Cells

Fixed cells like fibroblasts, macrophages, and adipocytes remain in connective tissue, while wandering cells like lymphocytes and blood cells move through the tissue.

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Dense Connective Tissue

A type of connective tissue characterized by thick bundles of fibers filling most of the extracellular space. It's strong and resists stretching.

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Dense Regular Connective Tissue

This type of dense connective tissue has fibers arranged in parallel, giving it strength in one direction. Found in tendons and ligaments.

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Dense Irregular Connective Tissue

This type of dense connective tissue has fibers arranged in a mesh-like pattern, giving it strength in multiple directions. Found in the dermis of the skin.

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Cartilage

A flexible connective tissue that's not as hard as bone but is strong and bends. Found in joints, rib cage, ears, nose, and more.

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Chondrocytes

Specialized cells found in cartilage, responsible for producing the extracellular matrix.

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Extracellular Matrix of Cartilage

The substance surrounding chondrocytes in cartilage, composed of collagen/elastic fibers and rich in proteoglycans. Provides support and flexibility.

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Types of Cartilage

Cartilage comes in three main types: hyaline, elastic, and fibrocartilage, each with different properties.

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Hyaline Cartilage

The most common type of cartilage. It's smooth, glassy, and found in joints, rib cage, nose, etc. Allows for smooth movement.

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Study Notes

Connective Tissue Overview

  • Connective tissue forms a framework for epithelial tissue.
  • Connective tissues provide structural support, transport nutrients, and offer immunological defense.
  • They also store energy, connect tissue types, facilitate movement, cushion and insulate, and protect delicate organs.

Connective Tissue Components

  • Cells are embedded in extracellular matrix.
  • The extracellular matrix is comprised of fibers and ground substance.
  • Fibrous material includes collagen, elastic, and reticular fibers.
  • Ground substance is fluid and chemical.
  • Cell types include fixed cells (e.g., fibroblasts, macrophages, adipocytes, mast cells) and wandering cells (e.g., lymphocytes, plasma cells, neutrophils, eosinophils, basophils, monocytes).

Fixed Cells

  • Fibroblasts: The most common cell type, synthesizing and excreting fibers.
  • Macrophages: Ingest foreign matter like bacteria. They originate from monocytes.
  • Adipocytes (Fat Cells): Store fats or lipids.
  • Mast Cells: Release chemical signals in response to injury, triggering inflammation and immune responses.

Wandering Cells

  • Lymphocytes (T and B): Part of the immune system, recognizing and binding to foreign substances. T cells are immunity cells; B cells produce plasma cells.
  • Plasma Cells: Specialized lymphocytes that produce and secrete antibodies.
  • Blood Cells: (Neutrophils, Eosinophils, Basophils): Part of the immune system, involved in responses to allergy, parasites, and infection. Monocytes enhance immune response.

Extracellular Matrix

  • Protein fibers secreted by fibroblasts are:
    • Collagen (most common, 25-30% of body's protein)
    • Reticular
    • Elastic
  • Ground substance: Fluid and chemicals including proteoglycans and glycosaminoglycans. This water-rich component makes up 60-80% of the substance.

Specialized Connective Tissue

  • Cartilage: Supportive connective tissue found in joints, rib cage, ear, and nose. Special types are hyaline, fibrocartilage, and elastic.

  • Hyaline Cartilage: Most abundant, found in articular cartilage, embryonic skeleton, costal cartilages, trachea. Hyaline cartilage is bluish-white with a matrix of chondroitin sulfate.

  • Fibrocartilage: Toughest, with densely packed collagen fibers and no perichondrium, found in intervertebral discs, menisci, and symphysis.

  • Elastic Cartilage: Possesses many elastic fibers, found in the ears and epiglottis.

  • Bone: A rigid connective tissue that provides support and protection and is responsible for movement. Bone is composed of:

    • Organic component (35%): Cells (osteoblasts, osteocytes, osteoclasts), collagen fibers.
    • Inorganic component (65%): Calcium phosphate, with magnesium, carbonate, and fluoride ions. Bone has a specialized ground substance called osteoid. Fibers are collagen Types I and V.
  • Blood: A liquid connective tissue without fibers and with highly fluid ground substance and mobile cells. It transports oxygen, hormones, nutrients and helps prevent disease. Blood's components are cells (RBC, WBC, platelets) and plasma (water and proteins).

Bone Cell Types

  • Osteoprogenitor cells: Give rise to osteoblasts.
  • Osteoblasts: Bone-forming cells synthesizing and secreting collagen and mineralized ground substance (calcium).
  • Osteocytes: Mature bone cells, smaller in appearance, maintaining calcium balance in the matrix.
  • Osteoclasts: Large cells from monocytes/macrophages, involved in bone growth, healing, and remodeling by digesting bone tissue.

Bone Structure

  • Bone structure includes Haversian canals.

Bone Ossification

  • Intramembranous ossification: Forms flat bones (skull, face) from vascularized areas, beginning with osteoprogenitor cells, then osteoblasts, and finally osteocytes.
  • Endochondral ossification: Forms long bones (like the humerus), starting as cartilage that transforms into bone.

Tissue and Aging

  • Tissue healing is less efficient in the elderly.
  • Cells divide more slowly.
  • Arteries lose elasticity.
  • Tendons and ligaments lose flexibility, becoming more fragile.
  • Blood cell synthesis declines.

Clinical Anatomy Aspects of Connective Tissue

  • Collagen type III deficiency can cause ruptures in arteries and intestines.
  • Connective tissue degeneration can occur (e.g., scurvy, tumor).

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