أسئلة المحاضرة الرابعة رمد (قبل التعديل)
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Questions and Answers

What are the main parts of the conjunctiva that cover the eye?

The main parts are the palpebral conjunctiva, bulbar conjunctiva, and fornices.

Describe the relationship between the palpebral conjunctiva and the tarsal plate.

The palpebral conjunctiva is adherent to the tarsal plate and cannot be easily dissected.

What is the significance of the conjunctival fold, or cul-de-sac, in eye anatomy?

The cul-de-sac allows for free movement of the eyeball and acts as a loose but thick membrane.

What types of cells are present in the conjunctival epithelium and what is their function?

<p>The conjunctival epithelium contains goblet cells that secrete mucus.</p> Signup and view all the answers

What are the constituents of the substantia propria of the conjunctiva?

<p>It consists of a superficial adenoid layer and a deep fibrous layer.</p> Signup and view all the answers

How do accessory lacrimal glands contribute to the health of the eye?

<p>Accessory lacrimal glands, like Krause's glands, help maintain moisture and lacrimal fluid balance.</p> Signup and view all the answers

What role do tears play in eye hygiene?

<p>Tears mechanically wash out microorganisms from the eye's surface.</p> Signup and view all the answers

What is the location and function of the caruncle in the conjunctival anatomy?

<p>The caruncle is a fleshy mass situated on the plica semilunaris, contributing to ocular lubrication.</p> Signup and view all the answers

How does lysozyme in lacrimal fluid contribute to eye health?

<p>Lysozyme inhibits the multiplication of most conjunctival micro-organisms, helping to prevent infections.</p> Signup and view all the answers

What role does the rapid reformation of conjunctival epithelium play in ocular protection?

<p>It acts as a barrier against bacteria and other pathogens, reducing the risk of ocular infections.</p> Signup and view all the answers

Identify two types of discharge that might indicate inflammation of the conjunctiva.

<p>Serous (watery) and mucopurulent are two types of discharge associated with conjunctival inflammation.</p> Signup and view all the answers

What are follicles in the conjunctiva, and what may cause their formation?

<p>Follicles are focal collections of lymphocytes caused by viral infections, chlamydia, or drug reactions.</p> Signup and view all the answers

Describe the appearance and cause of giant papillae in the conjunctiva.

<p>Giant papillae appear as large red bumps on the superior tarsal conjunctiva, often caused by chronic infections or prolonged contact lens wear.</p> Signup and view all the answers

What might cause chemosis in the conjunctiva?

<p>Chemosis, or edema of the conjunctival connective tissue, can result from inflammation, allergy, or infections.</p> Signup and view all the answers

How do focal collections of lymphocytes in the conjunctiva relate to specific infections?

<p>They are commonly caused by viral infections like adenovirus, herpes, or chlamydia, indicating an immune response.</p> Signup and view all the answers

What results from severe inflammation of the conjunctiva related to exudation?

<p>Severe inflammation can lead to the formation of a dirty grayish membrane on the surface due to exudation of inflammatory materials.</p> Signup and view all the answers

What are the clinical sure signs of corneal issues related to trachoma?

<p>The clinical sure signs include expressible follicles, pannus with Herbert's pits, Arlt's line, and post trachomatous degenerations.</p> Signup and view all the answers

What are the indications for oral azithromycin in treating trachoma?

<p>Oral azithromycin is indicated for new or recent-onset active disease.</p> Signup and view all the answers

What are the recommended treatments for acute non-infective conjunctivitis?

<p>Recommended treatments include astringent and vasoconstrictor drops, cold compresses, and artificial lubricants.</p> Signup and view all the answers

How can one manage chronic canaliculitis with epiphora?

<p>Management may include careful disinfection of infected fingers and early diagnosis and treatment.</p> Signup and view all the answers

What are some surgical options for trachoma-related eye conditions?

<p>Surgical options include expression of follicles, scraping of papillae, and picking of post trachomatous degenerations.</p> Signup and view all the answers

What symptoms are characteristic of acute allergic conjunctivitis?

<p>Characteristic symptoms include itching, eyelid swelling, watery or mucoid discharge, and hyperemia.</p> Signup and view all the answers

What approach should be taken when dealing with hypersensitivity in conjunctivitis patients?

<p>Patients should remove the cause of the allergy and may use antiallergic eye drops.</p> Signup and view all the answers

What are the differences between follicular and papillary conjunctivitis in terms of causes?

<p>Follicular conjunctivitis is differentiated from other causes by its specific signs, while papillary conjunctivitis differs mainly due to causes related to spring catarrh.</p> Signup and view all the answers

What characterizes the endpoint of cicatrization in ocular healing?

<p>The endpoint of cicatrization is marked by the absence of follicles or papillae.</p> Signup and view all the answers

What are the typical manifestations of superficial keratitis?

<p>Superficial keratitis is characterized by numerous epithelial erosions in the upper cornea that stain positive with fluorescein.</p> Signup and view all the answers

How does a trachomatous pannus typically present in the cornea?

<p>Trachomatous pannus presents with superficial vascularization and lymphoid infiltration of the upper cornea.</p> Signup and view all the answers

What are the consequences of complete resolution of trachomatous pannus?

<p>Complete resolution of trachomatous pannus can leave a clear cornea if the basement membrane is intact.</p> Signup and view all the answers

What symptoms might a patient with trachomatous pannus experience?

<p>Patients may experience pain, lacrimation, photophobia, and blepharospasm.</p> Signup and view all the answers

What is a common characteristic of typical trachomatous ulcers?

<p>Typical trachomatous ulcers are superficial, linear, and horizontal, usually located at the lower edge of the pannus.</p> Signup and view all the answers

What condition can result from local scarring around the lid margin in trachoma?

<p>Trichiasis can occur due to local scarring around the lid margin.</p> Signup and view all the answers

What are some potential complications associated with chronic trachoma?

<p>Complications may include posterior symblepharon, xerosis, and obstruction of the puncti due to fibrosis.</p> Signup and view all the answers

What are the characteristics of the discharge when papillae are exposed by lid eversion?

<p>The discharge is a sticky milky white film rich in eosinophils.</p> Signup and view all the answers

Describe the bulbar type of conjunctivitis.

<p>It manifests as gelatinous limbal masses with hypertrophied epithelium, usually starting at the upper limbus.</p> Signup and view all the answers

What are Tranta’s spots?

<p>Tranta’s spots are white spot concretions of eosinophils and necrotic epithelium seen in bulbar conjunctivitis.</p> Signup and view all the answers

How does the palpebral type of conjunctivitis differ from papillary trachoma?

<p>The palpebral type involves specific conjunctival reactions while papillary trachoma is associated with infection from Chlamydia.</p> Signup and view all the answers

What symptomatic treatments are recommended for conjunctivitis?

<p>Symptomatic treatments include dark glasses, cold compresses, and oral anti-histaminics if there is evident lid edema.</p> Signup and view all the answers

What precautions should be taken in the case of allergic conjunctivitis?

<p>Avoid exposure to known allergens is crucial to prevent irritation and exacerbation of symptoms.</p> Signup and view all the answers

What is the nature of the degeneration seen in elderly patients related to UV exposure?

<p>It is characterized by hyaline degeneration of subepithelial conjunctival tissue with elastoid tissue deposition.</p> Signup and view all the answers

What are the implications of prolonged use of topical steroids in treating conjunctivitis?

<p>Prolonged use may cause cataracts and secondary glaucoma, necessitating gradual tapering.</p> Signup and view all the answers

What is the primary condition affecting the conjunctival tissues mentioned in the content?

<p>Pterygium is the primary condition affecting the conjunctival tissues.</p> Signup and view all the answers

List two potential environmental factors contributing to the development of pterygium.

<p>UV rays and chronic irritation from dust and fumes are two potential environmental factors.</p> Signup and view all the answers

Describe the visual symptoms associated with pterygium.

<p>Symptoms include disfigurement and can lead to visual deterioration caused by astigmatism or pupil coverage.</p> Signup and view all the answers

What differentiates progressive pterygium from regressive pterygium?

<p>Progressive pterygium is thick, vascular, and fleshy, while regressive pterygium is thin, less vascular, and membranous.</p> Signup and view all the answers

What are the indications for surgical excision of pterygium?

<p>Surgical excision is indicated for symptomatic or progressive pterygium.</p> Signup and view all the answers

What is a key distinguishing feature of pseudo-pterygium compared to pterygium?

<p>Pseudo-pterygium is always stationary and can be attached to the base of a healed corneal ulcer.</p> Signup and view all the answers

What surgical methods are available for the treatment of pterygium?

<p>Surgical methods include simple excision, excision with bare scleral technique, and excision with grafting.</p> Signup and view all the answers

Why is it advised not to operate on small asymptomatic stationary pterygium?

<p>It is advised not to operate to avoid unnecessary surgical risks since they do not cause symptoms.</p> Signup and view all the answers

What surgical procedure may be indicated when the cornea is affected?

<p>Lamellar keratoplasty.</p> Signup and view all the answers

What treatment is known to prevent recurrence during surgery for conjunctival conditions?

<p>Mitomycin-C use.</p> Signup and view all the answers

Which condition is characterized by a cobblestone appearance of the conjunctiva?

<p>Spring catarrh.</p> Signup and view all the answers

In which condition are follicles not typically observed?

<p>Streptococcal conjunctivitis.</p> Signup and view all the answers

What should be avoided regarding bandaging in cases of corneal ulcers?

<p>Eyes should not be bandaged.</p> Signup and view all the answers

What is symblepharon and how is it typically formed?

<p>Symblepharon is an adhesion between different parts of the conjunctiva or between the conjunctiva and the cornea, commonly formed due to conditions like diphtheric conjunctivitis or chemical burns.</p> Signup and view all the answers

How do pseudo-membranes appear and what is their characteristic feature upon removal?

<p>Pseudo-membranes appear as white-grey nodules formed by the accumulation of white blood cells and can be easily removed, leaving an intact epithelial surface.</p> Signup and view all the answers

Explain the difference between conjunctival and ciliary injection.

<p>Conjunctival injection is marked by bright red, tortuous vessels that move freely with the conjunctiva, while ciliary injection features pink, blurred vessels that do not move with conjunctival movement.</p> Signup and view all the answers

What types of conjunctivitis are classified under bacterial infections?

<p>Bacterial conjunctivitis is commonly subdivided into mucopurulent conjunctivitis, characterized by specific discharge types.</p> Signup and view all the answers

What are the common bacterial agents responsible for purulent conjunctivitis in neonates?

<p>Gonococci and Chlamydia (serotypes D, E, and F) are the common bacterial agents.</p> Signup and view all the answers

What are the implications of using adrenaline on conjunctival vessels?

<p>Adrenaline constricts conjunctival vessels, making them less visible, which can be useful in reducing redness during certain ophthalmic procedures.</p> Signup and view all the answers

What is the recommended preventive measure for purulent conjunctivitis in newborns?

<p>Instillation of penicillin or broad-spectrum antibiotic eye drops after birth is recommended.</p> Signup and view all the answers

Identify at least two common causes of conjunctival symblepharon formation.

<p>Common causes include diphtheric conjunctivitis and alkali or acid burns.</p> Signup and view all the answers

Describe the appearance of follicles and their potential causes in the conjunctiva.

<p>Follicles appear as white-grey nodules due to white blood cell accumulation and may form in response to infections, allergens, or irritants.</p> Signup and view all the answers

Describe the conjunctival appearance during the infiltration stage of membranous conjunctivitis.

<p>Conjunctival edema covered with yellowish exudation and marked lid edema is present.</p> Signup and view all the answers

What systemic manifestations are associated with the infection caused by Corynebacterium diphtheriae?

<p>Fever and malaise are the systemic manifestations related to the infection.</p> Signup and view all the answers

What are the main characteristics of papillae seen in conjunctivitis?

<p>Papillae appear as inflamed areas of elevated conjunctiva and are indicative of allergic or irritant conjunctivitis.</p> Signup and view all the answers

What should be suspected if a newborn shows any discharge from the eyes during the first week of life?

<p>Any discharge, even watery, should be viewed with suspicion due to the absence of tear secretion.</p> Signup and view all the answers

What treatment may be necessary for severe cases of purulent conjunctivitis in newborns?

<p>Systemic antibiotics may be required for severe cases.</p> Signup and view all the answers

What distinguishes the discharge during the stage of discharge in membranous conjunctivitis?

<p>The discharge is purulent and stained with blood, containing pieces of sloughed membrane.</p> Signup and view all the answers

How does washing the baby's body from above downward help prevent infections during delivery?

<p>It reduces the risk of contamination from maternal passages during delivery.</p> Signup and view all the answers

What type of antibiotic treatment is recommended for purulent conjunctivitis in severe cases?

<p>Systemic antibiotics are recommended.</p> Signup and view all the answers

What is the most common causative organism of purulent conjunctivitis?

<p>Gonococci are the most common causative organisms.</p> Signup and view all the answers

Describe the clinical manifestations during the infiltration stage of gonococcal conjunctivitis.

<p>Lid edema, marked conjunctival edema, and hyperemia are observed.</p> Signup and view all the answers

What local treatment options are recommended for gonococcal conjunctivitis?

<p>Gentamycin or Bacitracin drops and ointment are recommended.</p> Signup and view all the answers

What complication can arise from gonococcal conjunctivitis if not treated properly?

<p>Severe corneal ulcers that can lead to perforation may develop.</p> Signup and view all the answers

How does purulent conjunctivitis typically progress over time?

<p>It tends to disappear spontaneously within 2 weeks or after treatment.</p> Signup and view all the answers

Why is it advised against using bandages for purulent conjunctivitis?

<p>Bandages can accumulate discharge and allow more microbial multiplication.</p> Signup and view all the answers

What specific symptom indicates the presence of enlarged tender pre-auricular lymph nodes in purulent conjunctivitis?

<p>The presence of tender pre-auricular lymph nodes indicates lymphadenopathy.</p> Signup and view all the answers

What is the primary distinction between progressive and regressive pannus?

<p>Progressive pannus involves infiltration and an increase in vascularization, whereas regressive pannus shows narrowing of vessels and a decrease in infiltration.</p> Signup and view all the answers

What are Herbert's rosettes and their significance in corneal pathology?

<p>Herbert's rosettes are sub-epithelial lymphoid infiltrations that indicate a chronic inflammatory process in the cornea, often seen in trachoma.</p> Signup and view all the answers

Describe the healing outcome if the basement membrane is destroyed during the resolution of trachomatous pannus.

<p>If the basement membrane is destroyed, it results in permanent opacity of the cornea, known as pannus siccus.</p> Signup and view all the answers

What clinical features are associated with typical trachomatous ulcers?

<p>Typical trachomatous ulcers are characterized as superficial, chronic, linear, and horizontal, located at the lower edge of the pannus.</p> Signup and view all the answers

Explain the role of xerosis in ocular pathology related to trachoma.

<p>Xerosis refers to dryness caused by the obstruction of lacrimal ducts and fibrosis of lacrimal glands, leading to compromised tear film stability.</p> Signup and view all the answers

What are the implications of cicatricial entropion in patients with trachoma?

<p>Cicatricial entropion results from conjunctival shrinkage, causing the eyelid margin to turn inwards, which can lead to corneal damage.</p> Signup and view all the answers

What symptoms are commonly associated with corneal issues in trachoma patients?

<p>Common symptoms include pain, lacrimation, photophobia, and blepharospasm.</p> Signup and view all the answers

What occurs during the healing process of superficial keratitis as observed with fluorescein?

<p>The presence of numerous epithelial erosions, which stain positively with fluorescein, indicates damage that occurs before the healing process.</p> Signup and view all the answers

What degenerative condition is characterized by vascularized granulation tissue encroaching upon the cornea?

<p>Pterygium</p> Signup and view all the answers

What environmental factor is considered most significant in the development of pterygium?

<p>UV rays</p> Signup and view all the answers

What is the primary symptom associated with pterygium that patients may experience?

<p>Disfigurement</p> Signup and view all the answers

What distinguishes progressive pterygium from regressive pterygium?

<p>Progressive pterygium is thick and vascular, while regressive pterygium is thin and membranous.</p> Signup and view all the answers

What surgical method is indicated for a symptomatic or progressive pterygium?

<p>Surgical excision</p> Signup and view all the answers

How can one differentiate between pterygium and pseudo-pterygium?

<p>Pterygium is bilateral and attached to the conjunctiva at the neck, whereas pseudo-pterygium can be unilateral and is attached to the base of a healed corneal ulcer.</p> Signup and view all the answers

What are the visible components of a pterygium described in the clinical picture?

<p>Head, neck, and body.</p> Signup and view all the answers

What is the common recommendation for small, asymptomatic stationary pterygium?

<p>Better not to operate.</p> Signup and view all the answers

Which type of conjunctivitis is characterized by a discharge that is mucopurulent?

<p>Gonococcal conjunctivitis</p> Signup and view all the answers

What is the causative agent primarily responsible for trachoma conjunctivitis?

<p>Chlamydia</p> Signup and view all the answers

Which of the following is NOT a common symptom of purulent conjunctivitis?

<p>Hemorrhagic discharge</p> Signup and view all the answers

In which type of conjunctivitis is conjunctival chemosis most commonly observed?

<p>Giant papillary conjunctivitis</p> Signup and view all the answers

What preventative measure can help reduce the transmission of conjunctivitis in infected individuals?

<p>Frequent washing of hands and face</p> Signup and view all the answers

What is a key characteristic of acute haemorrhagic conjunctivitis?

<p>High incidence during specific months</p> Signup and view all the answers

Which condition is likely to lead to corneal ulceration if there is additional abrasion of the cornea during infection?

<p>Purulent conjunctivitis</p> Signup and view all the answers

What is the main symptom of conjunctivitis that may lead to the gluing of lashes in the morning?

<p>Mucopurulent discharge</p> Signup and view all the answers

What is the primary cause of purulent conjunctivitis in the first month of life?

<p>Contamination during delivery</p> Signup and view all the answers

Which bacterium is most commonly associated with purulent conjunctivitis in newborns?

<p>Gonococcus</p> Signup and view all the answers

What preventive measure should be taken to protect newborns from conjunctivitis?

<p>Instilling penicillin eye drops after birth</p> Signup and view all the answers

What symptom should be viewed with suspicion in a baby during the first week of life?

<p>Watery discharge from the eyes</p> Signup and view all the answers

What type of conjunctivitis is linked to non-immunized children?

<p>Membranous conjunctivitis</p> Signup and view all the answers

Which systemic symptoms can accompany conjunctival infections?

<p>Fever and malaise</p> Signup and view all the answers

When a membrane separates in membranous conjunctivitis, what does it leave behind?

<p>Septic granulation tissue</p> Signup and view all the answers

What should be done frequently to manage purulent conjunctivitis?

<p>Frequent removal of discharge</p> Signup and view all the answers

What is a local complication of cicatrization in the conjunctiva?

<p>Xerosis</p> Signup and view all the answers

Which symptom is associated with acute viral conjunctivitis?

<p>Preauricular lymphadenopathy</p> Signup and view all the answers

What type of treatment is administered to neutralize the diphtheritic exotoxin?

<p>Anti-diphtheritic serum</p> Signup and view all the answers

Which of the following indicates a general complication of diphtheritic infection?

<p>Toxic nephritis</p> Signup and view all the answers

What is a commonly observed sign of adenoviral conjunctivitis?

<p>Conjunctival follicles</p> Signup and view all the answers

Which condition may result from viral conjunctivitis if cornea is affected?

<p>Corneal affection requiring anti-virals</p> Signup and view all the answers

Which of the following is a preventive measure against diphtheria?

<p>Isolation of patients</p> Signup and view all the answers

What kind of discharge is typically seen in conjunctival infections?

<p>Watery discharge</p> Signup and view all the answers

What is a clinical sure sign of corneal issues related to trachoma?

<p>Arlt's line</p> Signup and view all the answers

What is the recommended treatment for chronic canaliculitis with epiphora?

<p>Surgical scraping of the canaliculus</p> Signup and view all the answers

Which medication should be used as a first-line treatment for active trachoma?

<p>Oral azithromycin</p> Signup and view all the answers

What is typically seen in a patient experiencing acute allergic conjunctivitis?

<p>Watery or mucoid discharge</p> Signup and view all the answers

Which of the following is a common treatment for non-infective conjunctivitis?

<p>Cold compresses</p> Signup and view all the answers

What type of body can be identified in conjunctival scrapings when diagnosing certain conditions?

<p>Intracytoplasmic basophilic inclusion bodies</p> Signup and view all the answers

Which of the following represents a hypersensitivity reaction seen in conjunctivitis?

<p>Contact dermatitis</p> Signup and view all the answers

What is a common characteristic of conjunctivitis caused by environmental allergens?

<p>Itching and eyelid swelling</p> Signup and view all the answers

What is characteristic of the healing process in trachomatous pannus?

<p>Complete resolution often leaves a clear cornea if the basement membrane is intact.</p> Signup and view all the answers

Which feature differentiates progressive pannus from regressive pannus?

<p>In progressive pannus, infiltration precedes vascularization.</p> Signup and view all the answers

What is a symptom associated with corneal ulcers due to trachoma?

<p>Superficial linear horizontal ulcers at the lower edge of the pannus.</p> Signup and view all the answers

Which of the following is NOT a characteristic of superficial keratitis?

<p>Deep penetration of the corneal stroma.</p> Signup and view all the answers

What condition can result from chronic meibomianitis?

<p>Dry eye syndrome due to gland obstruction.</p> Signup and view all the answers

What describes the appearance of corneal follicles in the context of trachoma?

<p>They appear as superficial, raised pale spots.</p> Signup and view all the answers

Which of the following outcomes is expected if the basement membrane is destroyed during healing?

<p>Permanent opacity known as pannus siccus.</p> Signup and view all the answers

What symptom might occur due to trichiasis in trachoma?

<p>Eyelashes turning inward, causing irritation.</p> Signup and view all the answers

What are the adhesions formed between the conjunctiva and the cornea called?

<p>Symblepharon</p> Signup and view all the answers

Which of the following is NOT a common cause of symblepharon?

<p>Dry eye syndrome</p> Signup and view all the answers

What characteristic feature differentiates conjunctival injection from ciliary injection?

<p>Vessels cannot move with conjunctiva</p> Signup and view all the answers

Which type of conjunctivitis is specifically associated with mucopurulent discharge?

<p>Bacterial conjunctivitis</p> Signup and view all the answers

What is the typical appearance of follicles in the conjunctiva?

<p>White-grey nodules</p> Signup and view all the answers

Which blood vessel type is more marked at the fornix during conjunctival injection?

<p>Superficial conjunctival vessels</p> Signup and view all the answers

Which condition is least likely to result in keratitis?

<p>Mucopurulent conjunctivitis</p> Signup and view all the answers

What aspect of conjunctival injection results in a tortuous appearance of blood vessels?

<p>Inflammation of the conjunctiva</p> Signup and view all the answers

Which type of conjunctivitis is specifically categorized as purulent conjunctivitis in adults?

<p>Gonococcal conjunctivitis</p> Signup and view all the answers

What is a significant characteristic of viral conjunctivitis as discussed?

<p>It usually shows a follicular appearance.</p> Signup and view all the answers

Which condition is indicated as a chronic infective conjunctivitis?

<p>Angular conjunctivitis</p> Signup and view all the answers

Which agent is associated with causing epidemics of conjunctivitis during specific months?

<p>Koch-Weeks bacillus</p> Signup and view all the answers

Which symptom is NOT typically associated with purulent conjunctivitis?

<p>Intense itching</p> Signup and view all the answers

What could occur if the cornea is abraded during a purulent conjunctivitis infection?

<p>Development of a superficial corneal ulcer</p> Signup and view all the answers

Which management strategy is emphasized for individuals infected with conjunctivitis?

<p>Washing linens and towels of infected patients privately</p> Signup and view all the answers

What is the course of purulent conjunctivitis if left untreated?

<p>It typically resolves in two weeks.</p> Signup and view all the answers

Which condition is characterized by a cobblestone appearance of the conjunctiva?

<p>Spring catarrh</p> Signup and view all the answers

In which condition are follicles not typically observed?

<p>Streptococcal conjunctivitis</p> Signup and view all the answers

What is the primary causative agent of angular conjunctivitis?

<p>Morax-Axenfeld bacillus</p> Signup and view all the answers

Herbert’s pits are associated with which ocular condition?

<p>Trachoma</p> Signup and view all the answers

Which type of conjunctivitis is associated with true membranous conjunctivitis?

<p>Diphtheria</p> Signup and view all the answers

Which bacterial agent is NOT typically associated with causing purulent conjunctivitis in newborns?

<p>Corynebacterium diphtheriae</p> Signup and view all the answers

What is the recommended treatment method for severe cases of purulent conjunctivitis in neonates?

<p>Systemic antibiotics</p> Signup and view all the answers

What symptom indicates that any discharge from a newborn's eyes during the first week of life should be taken seriously?

<p>Even watery secretion is present</p> Signup and view all the answers

Which of the following options is FALSE regarding the clinical stages of membranous conjunctivitis caused by diphtheriae?

<p>Purulent blood-stained discharge only appears in the first stage.</p> Signup and view all the answers

What is NOT a preventive measure for purulent conjunctivitis in newborns?

<p>Administering systemic antibiotics to the mother</p> Signup and view all the answers

Which of the following is a common systemic manifestation associated with ocular symptoms of membranous conjunctivitis?

<p>Constitutional symptoms like fever</p> Signup and view all the answers

In cases of purulent conjunctivitis, which treatment method is recommended for frequent use at night?

<p>Antibiotic ointment</p> Signup and view all the answers

What is a defining characteristic of the discharge in the second stage of diphtheritic conjunctivitis?

<p>Thick yellow pus with granulation tissue</p> Signup and view all the answers

What local complication can result from cicatrization in the conjunctiva?

<p>Xerosis</p> Signup and view all the answers

Which condition is primarily associated with the diphtheritic exotoxin complications?

<p>Nephritis</p> Signup and view all the answers

Which of the following treatments is specifically indicated for corneal ulcers in conjunctivitis cases?

<p>Local Atropine ointment</p> Signup and view all the answers

How does acute viral conjunctivitis typically manifest in terms of conjunctival follicles?

<p>Follicles are primarily noted in the lower palpebral conjunctiva.</p> Signup and view all the answers

Which preventative measure is essential against diphtheria-related complications?

<p>Notification of health authorities</p> Signup and view all the answers

What is a common characteristic of adenoviral conjunctivitis?

<p>Presence of preauricular lymphadenopathy</p> Signup and view all the answers

Which of the following describes treatment for acute haemorrhagic conjunctivitis?

<p>Treatment is generally supportive and self-limited.</p> Signup and view all the answers

What complication could arise from the closure of ducts in the lacrimal system?

<p>Xerosis</p> Signup and view all the answers

Which sign is NOT associated with clinical manifestations of trachoma?

<p>Hyperemia</p> Signup and view all the answers

What is the most appropriate treatment option for chronic canaliculitis with epiphora?

<p>Oral azithromycin</p> Signup and view all the answers

What reaction occurs minutes after exposure to allergens in acute allergic conjunctivitis?

<p>Itching and eyelid swelling</p> Signup and view all the answers

Which of the following treatments is appropriate for acute non-infective conjunctivitis?

<p>Astringent and vasoconstrictor drops</p> Signup and view all the answers

What is the role of atropine in the treatment of ocular conditions mentioned?

<p>Alleviate corneal involvement</p> Signup and view all the answers

What is a common characteristic of discharge typically associated with papillary conjunctivitis?

<p>Mucopurulent</p> Signup and view all the answers

In the management of conjuctivitis, which of the following is NOT considered a symptomatic treatment?

<p>Use of topical antibiotics</p> Signup and view all the answers

What differentiates papillary conjunctivitis from trachomatous conjunctivitis?

<p>Underlying allergen sensitivity</p> Signup and view all the answers

What is a key characteristic of follicles formed in chronic conjunctival infection?

<p>Non expressible and flat</p> Signup and view all the answers

Which statement accurately describes the mode of transmission for Chlamydia trachomatis?

<p>Transferred by both direct contact and flies</p> Signup and view all the answers

What type of healing occurs in the conjunctiva following chronic infection?

<p>Cicatrisation</p> Signup and view all the answers

What is a significant complication of untreated trachoma?

<p>Permanent visual impairment or blindness</p> Signup and view all the answers

Which environmental factor significantly contributes to the prevalence of trachoma?

<p>Socioeconomic status of affected communities</p> Signup and view all the answers

What is the role of topical povidone iodine in treating conjunctival infections?

<p>It prevents secondary bacterial infections</p> Signup and view all the answers

What type of lesions are formed in the conjunctiva during the progression of chronic trachoma?

<p>Pinkish, raised papillae within follicles</p> Signup and view all the answers

What significant figure is associated with the world's trachoma blind population?

<p>1.9 million</p> Signup and view all the answers

Study Notes

Applied Anatomy of Conjunctiva

  • Thin, translucent, vascular mucous membrane covering underside of eyelids and reflected over anterior part of eyeball to limbus
  • Considered the wrapping membrane of the eye
  • Covers both upper and lower lids
  • Palpebral conjunctiva adheres to tarsus, difficult to dissect
  • Very thin
  • Marginal conjunctiva starts at grey line, merges into sub-tarsal groove
  • Tarsal conjunctiva is thin, transparent, highly vascular, adheres closely to tarsal plate
  • Orbital conjunctiva lies between proximal border of tarsal plate and fornix
  • Bulbar conjunctiva covers anterior part of eyeball
  • Loosely attached to underlying tissue but firmly adherent to Tenon's capsule 3mm around the limbus

Parts of the Conjunctiva

  • Palpebral Conjunctiva: Covers inner surface of eyelids.
  • Bulbar Conjunctiva: Covers the anterior surface of the eyeball.
  • Fornix: Fold where palpebral and bulbar conjunctiva meet.
  • Caruncle: Small fleshy mass at the inner corner of the eye.
  • Plica Semilunaris: Crescent-shaped fold of conjunctiva at inner corner.

Conjunctiva Histology

  • Epithelium: Stratified squamous, non-keratinized epithelium containing goblet cells that secrete mucus.
    • Connective tissue underlying epithelium:
      • Superficial adenoid layer: fine fibrous network, infiltrated by lymphocytes and few mast cells and histocytes
      • Deep fibrous layer: thick collagenous and elastic fibers (absent over tarsal region).
  • Substantia Propria: Layer with glands, like Krause and Wolfring's glands

Blood Supply, Lymphatic Drainage, and Conjunctival Infection

  • Anterior and posterior conjunctival arteries and veins
  • Preauricular and submandibular lymph nodes
  • Micro-organisms are washed out by tears' flow
  • Lysozyme inhibits micro-organism multiplication
  • Conjunctival epithelium desquamation and rapid reformation is a barrier
  • Abundant lymphoid tissue in conjunctiva

Pathological Manifestations of Conjunctival Inflammations

  • Irritation: Discomfort, itching, burning, foreign body sensation. Discharge like watery, mucoid, mucopurulent, or purulent
  • Chemosis: Edema of subepithelial connective tissue (conjunctival injection)
  • Hyperemia: Blood vessel dilatation; focal lymphocyte collections in conjunctiva
  • Follicles: Lymphocyte collections in conjunctiva (prominent in inferior fornix as gelatinous elevations)
  • Viral Infections: Adenovirus, Herpes, Molluscum contagiosum, Chlamydia (trachoma, adult inclusion conjunctivitis)
  • Drug Reactions: Atropine, Epinephrine, glaucoma medications

Papillae and Giant Papillae

  • Non-specific response to chronic irritation, epithelial proliferation with vascular core, seen on superior tarsal conjunctiva as red bumps with central vessels
  • Causes: chronic infections, allergy
  • Giant papillae: Chronic inflammation causes these papillae to fuse and enlarge

Membranes and Pseudo Membranes

  • Damage to conjunctival vessels and surface epithelium can lead to fibrin, inflammatory cells, necrotic cells formation on surface, raw bleeding surface
  • Symblepharon: Adhesions between conjunctiva parts
  • Causes of adhesions: Diphtheric conjunctivitis, alkali/acid burns, severe viral infections
  • Pseudo-membranes: Formed by discharge and exudates; easily removable, leaving intact epithelium

Conjunctival Injection (Blood Vessels)

  • Bright red in color; tortuous and dilated blood vessels
  • Superficial, moves freely with conjunctiva; marked at fornix; vessels not blurred
  • Constriction by adrenaline
  • Posterior conjunctival vessels
  • Causes: conjunctivitis, keratitis, corneal ulcer, iridocyclitis

Classification of Conjunctivitis

  • Acute Infectious: Mucopurulent, Purulent (gonococcal, ophthalmia neonatorum), Membranous (pseudo or true)
  • Chronic Infectious: Adenoviral, hemorrhagic, herpetic, Angular, Trachoma (Chlamydia)
  • Non-infectious: Hypersensitivity to exogenous allergen (vernal, atopic, giant papillary), hypersensitivity to endogenous allergen (phlyctenular)

Mucopurulent Conjunctivitis (MPC)

  • Causative agents: Koch-Weeks bacillus, S. aureus, epidermidis, Pneumococci
  • Symptoms: discomfort, redness, mucopurulent discharge, haloes around light, heat sensation
  • Signs: lid edema, conjunctival hyperemia, mucopurulent discharge, gluing of lashes, conjunctival edema, petechial hemorrhage

Purulent Conjunctivitis

  • Acute suppurative inflammation with pus formation and enlarged lymph nodes
  • Causative agents: Gonococci (80%), Streptococci, Staphylococci
  • Types: Epidemic (summer), Genital (auto-infection), Ophthalmia neonatorum
  • Clinical features: Incubation period (few hours to 3 days)
  • Initial stage (infiltration): Lid edema, tenderness, marked conjunctival edema, marked hyperemia. Later (Discharge) stage: decreased lid edema, decreased edema and hyperemia, profuse purulent discharge.

Ophthalmia Neonatorum

  • Conjunctival inflammation in newborns, usually due to contamination
  • Causative agents: Gonococci, Chlamydia, Herpes Simplex, Other bacteria
  • Prevention: Washing the baby, penicillin/broad-spectrum antibiotics
  • Treatment: Local antibiotic eye drops, frequent discharge removal, systemic antibiotics

Membranous Conjunctivitis

  • Rare, affects non-immunized children
  • Caused by Corynebacterium diphtheria (incubation period 12-72 hours)
  • Systemic manifestations: Infection of the throat/nasopharynx, fever, malaise
  • Ocular manifestations:
    • Stage of infiltration: Lid edema, redness, tenderness,
    • Conjunctival edema, yellowish exudation, scanty mucopurulent discharge. True grayish membrane possibly covering the palpebral conjunctiva
    • Stage of discharge: Marked hyperemia, purulent, blood-stained discharge, sloughed membrane,
    • Septic granulation tissue with thick yellow pus when the membrane separates

Trachoma

  • Chronic infection of conjunctiva, cornea
  • Causative agent: Chlamydia trachomatis
  • Characterized by: Formation of follicles and papillae in the upper tarsal conjunctiva, Formation of pannus in the upper cornea, Healing occurs by cicatrisation
  • Based on 2022 WHO data: 125 million people at risk of blindness, 1.9 million affected, before antibiotic availability, trachoma was the leading cause of preventable blindness globally

Acute Viral Conjunctivitis

  • Typically adenoviral, haemorrhagic, herpetic
  • Acute follicular conjunctivitis, follicles formation
  • Symptoms: Droplet infection, sore throat, red eye with conjunctival follicles (more in lower palpebral conjunctiva and lower fornix). Preauricular lymphadenopathy, subconjunctival hemorrhages, photophobia, watery discharge
  • Treatment: No specific treatment, usually self-limiting, artificial tears, antibiotics for secondary bacterial infections, Antivirals for corneal affection, Povidone iodine 5% drops

Vernal Keratoconjunctivitis (Spring Catarrh)

  • Chronic bilateral allergic inflammation of conjunctiva, usually affecting children (5–25 years) during spring and summer
  • Etiology: Allergic reaction to unknown exogenous factors (dust, pollen)
  • Symptoms: Itching, lacrimation, hyperemia, photophobia, blepharospasm, scant whitish ropy mucoid discharge
  • Palpebral type: Large flat-topped papillae give a cobblestone appearance on the tarsus, absence of papillae in the fornix, bluish-white to red papillae formed of central fibrous tissue rich in eosinophils, covered by thick epithelium, center and edges of papillae have tiny blood vessels, sticky milky white film of discharge rich in eosinophils.

Mixed Type, Bulbar Type of Vernal Keratoconjunctivitis

  • Mixture of palpebral and bulbar types, generally more severe
  • Bulbar type: Manifests as gelatinous limbal masses formed of hypertrophied epithelium, with CT core, and hyaline degeneration, usually starts at upper limbus then all round, white spots, Tranta's spots.
  • Other corneal manifestations:
    • Fine punctate epithelial keratitis, Rarely vernal corneal ulcers
  • Differential diagnosis: Palpebral should differentiate from papillary trachoma, bulbar from limbal phlycten
  • Diff Dx: Giant papillary conjunctivitis: Foreign bodies

Acute Allergic Conjunctivitis

  • Hypersensitivity to airborne plant/animal allergens (asthma, hay fever, atopy).
  • Symptoms: Itching, eyelid swelling (minutes after exposure), watery or mucoid discharge, hyperemia, edema of lids & conjunctiva
  • Treatment: Remove the cause, cold compresses, astringent/vasoconstrictor drops, artificial lubricants, non-steroidal anti-inflammatories, antiallergic eye drops, topical steroids

Chronic Non-infective Conjunctivitis

  • Hypersensitivity to endogenous antigen(tuberculo-protein, intestinal parasites, septic foci, staphylococcal blepharoconjunctivitis
  • Symptoms: Irritation, discomfort, burning, foreign body sensation, watery/mucoid discharge, photophobia, blepharospasm (especially with corneal affection)
  • Signs: Rounded, raised nodules (phlycten), greyish/yellowish in color, commonly at limbus/bulbar conjunctiva, formed of lymphocytic aggregation covered by intact epithelium (ulcerating with secondary infection), small area of congestion
  • Treatment(s), no specific

Pinguecula/Pterygium

  • Pinguecula: Degenerative condition affecting elderly, common in dry sunny climates, usually on the nasal side of the limbus
  • Characterized by: Hyaline degeneration of subepithelial conjunctival tissue with elastoid tissue, deposits, triangular shape (base towards cornea)
  • Treatment: No treatment needed, excision for cosmetic reasons if necessary
  • Pterygium: Degenerative condition, subconjunctival tissue proliferation, vascularised granulation tissue invading cornea, often unknown cause, commonly in dry climates
  • Treatment(s): Excision, grafting (conjunctival auto-graft, limbal stem-cell graft, amniotic membrane).

Differential Diagnosis

  • Important to consider other conditions that might have similar symptoms.

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