Concepts of Hemostasis and Thrombosis Quiz
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Questions and Answers

What is the potential outcome of venous thrombosis known as?

  • Pulmonary Embolism (correct)
  • Hemorrhage
  • Arteriosclerosis
  • Aneurysm

    • Which gene mutation is commonly associated with an increased risk of venous thrombosis in Caucasians?

  • Antithrombin III mutation
  • Factor XIII gene mutation
  • Protein C mutation
  • Factor V gene mutation (correct)

    • What diagnostic method is used for detecting pulmonary embolism and other vascular abnormalities?

  • Endoscopy
  • Doppler ultrasound (correct)
  • Echocardiography
  • Electrocardiogram

    • Which laboratory test is recommended for monitoring unfractionated heparin (UFH) and low molecular weight heparins (LMWHs)?

    <p>Anti-Xa level test</p> Signup and view all the answers

    What is the Leiden mutation associated with in terms of clotting risk?

    <p>Increased risk of venous thrombosis</p> Signup and view all the answers

    Which factor is not typically tested in laboratory evaluation for thrombotic disorders?

    <p>Brain natriuretic peptide (BNP)</p> Signup and view all the answers

    Which of the following drugs has efficacy for non Q wave, Non STEMI, and unstable angina?

    <p>Tirofiban</p> Signup and view all the answers

    Which enzyme is needed to activate clopidogrel, and is estimated to be low in 2-14% of the US population?

    <p>CYP 2C19</p> Signup and view all the answers

    What is the timeframe within which platelet aggregation is restored after cessation of eptifibatide infusion?

    <p>6 hours</p> Signup and view all the answers

    Which drug is a nonpeptide IIbIIIa inhibitor given before and after angioplasty or atherectomy?

    <p>Tirofiban</p> Signup and view all the answers

    What is the mechanism of action of eptifibatide and tirofiban in inhibiting platelet aggregation?

    <p>Antiplatelet effect</p> Signup and view all the answers

    What is the main concern regarding the adverse effects of Aspirin?

    <p>Gastric and duodenal ulcers</p> Signup and view all the answers

    Which drug interaction with Aspirin can lead to increased bleeding?

    <p>Angiotensin-converting enzyme inhibitors (ACEIs)</p> Signup and view all the answers

    What is the major metabolic pathway for Aspirin?

    <p>Salicyl phenolic glucuronide</p> Signup and view all the answers

    Which group of individuals is NOT recommended to receive Aspirin according to the text?

    <p>Children less than 12 years old</p> Signup and view all the answers

    What is a common adverse effect associated with Aspirin use in asthmatics?

    <p>Tinnitis</p> Signup and view all the answers

    What is one of the therapeutic uses of Aspirin as mentioned in the text?

    <p>Secondary prevention of coronary events like stroke and MI</p> Signup and view all the answers

    What is the main function of Abciximab (ReoPro) in preventing platelet aggregation?

    <p>Inhibiting the activation of GPIIb</p> Signup and view all the answers

    Why must GP IIB/IIIA receptor antagonists like Tirofiban be given by continuous infusion?

    <p>Because of their short half-lives</p> Signup and view all the answers

    Which of the following statements about Dipyridamole is TRUE?

    <p>It may be used for myocardial stress testing</p> Signup and view all the answers

    How does aspirin-dipyridamole (Aggrenox®) help in preventing CVA after stroke/TIA?

    <p>By inhibiting thromboxane A2 activation</p> Signup and view all the answers

    Which factor may reverse the effects of an overdose of Abciximab (ReoPro)?

    <p>Aminophylline</p> Signup and view all the answers

    Why should Abciximab (ReoPro) not be used if CrCl is less than 10mL/min?

    <p>Concerns about renal clearance</p> Signup and view all the answers

    What is the function of PRAXBIND (IDARUCIZUMAB)?

    <p>Reversing complete anticoagulation caused by Pradaxa</p> Signup and view all the answers

    Which adverse reaction is associated with the administration of PRAXBIND?

    <p>Hypokalemia</p> Signup and view all the answers

    What is the primary target of Vorapaxar (Zontivity)?

    <p>Platelet aggregation</p> Signup and view all the answers

    Why is Vorapaxar contraindicated in patients with a history of intracranial bleeds or stroke?

    <p>To avoid thromboembolic risk</p> Signup and view all the answers

    How does the half-life of Vorapaxar compare to that of PRAXBIND (IDARUCIZUMAB)?

    <p>PRAXBIND has a longer half-life</p> Signup and view all the answers

    Which type of drug interaction affects the exposure of Vorapaxar?

    <p>Potent CYP3A4 inducers</p> Signup and view all the answers

    What is the main function of Tissue Factor Pathway Inhibitor?

    <p>Prevents activation of factors IX and X</p> Signup and view all the answers

    Which platelet receptor is involved in platelet adhesion to exposed collagen?

    <p>GpIb</p> Signup and view all the answers

    What stimulates the formation of a primary hemostatic plug on the platelet surface?

    <p>ADP</p> Signup and view all the answers

    Which molecule is important for platelet aggregation along with ADP and thrombin?

    <p>Thromboxane A2 (TxA2)</p> Signup and view all the answers

    Which enzyme is synthesized by endothelial cells and activates the extrinsic clotting cascade?

    <p>Tissue factor (factor III)</p> Signup and view all the answers

    What is the role of GpIIb-IIIa receptors in platelet aggregation?

    <p>Bind fibrinogen</p> Signup and view all the answers

    What is the main metabolic pathway for Clopidogrel (Plavix)?

    <p>Liver excretion</p> Signup and view all the answers

    Which CYP2C19 inhibitor can decrease the action of Clopidogrel on platelets?

    <p>Cimetidine</p> Signup and view all the answers

    What is the main therapeutic use of Prasugrel (Effient)?

    <p>Prevention of thrombotic events after TIA</p> Signup and view all the answers

    Which adverse effect is a black box warning associated with the use of Prasugrel?

    <p>Fatal bleeding</p> Signup and view all the answers

    Why should Prasugrel be avoided in patients with cerebrovascular disease or aged over 75?

    <p>Reduced effectiveness on platelets</p> Signup and view all the answers

    What class of drugs should be monitored when initiating treatment with Prasugrel to avoid adverse effects?

    <p>Statins</p> Signup and view all the answers

    Which drug is used for prevention of CVA after stroke/TIA and may be used for myocardial stress testing?

    <p>Dipyridamole</p> Signup and view all the answers

    Why must GP IIB/IIIA receptor antagonists be given by continuous infusion?

    <p>To ensure consistent platelet inhibition</p> Signup and view all the answers

    Which drug is a Fab fragment of a human monoclonal antibody with a duration of action lasting 18-24 hours?

    <p>Abciximab</p> Signup and view all the answers

    What happens if major bleeding occurs while using Abciximab (ReoPro)?

    <p>Platelet transfusion may reverse aggregation defect</p> Signup and view all the answers

    What is the primary mechanism of action of GP IIB/IIIA receptor antagonists like Eptifibatide and Tirofiban?

    <p>Binding to glycoprotein receptor IIbIIIa preventing aggregation</p> Signup and view all the answers

    Why should Aspirin-Dipyridamole (Aggrenox®) not be used if CrCl is less than 10mL/min?

    <p>Reduced efficacy due to impaired clearance</p> Signup and view all the answers

    Why should Betrixaban not be used in patients with non-valvular atrial fibrillation?

    <p>Increased risk of stroke</p> Signup and view all the answers

    Which medication is used as an antidote for Betrixaban (Bevyxxa) in case of overdose?

    <p>Andexxa</p> Signup and view all the answers

    What is the recommended duration of Betrixaban (Bevyxxa) therapy for deep vein thrombosis (DVT) prophylaxis?

    <p>35-42 days</p> Signup and view all the answers

    Which medication should have its dose reduced when co-administered with P-glycoprotein inhibitors like quinidine and ketoconazole?

    <p>Betrixaban</p> Signup and view all the answers

    What is the effective half-life of Betrixaban (Bevyxxa)?

    <p>19-27 hours</p> Signup and view all the answers

    How long does it take for PRAXBIND (IDARUCIZUMAB) to achieve complete anticoagulation reversal?

    <p>4 hours</p> Signup and view all the answers

    Which adverse reaction is NOT associated with the administration of PRAXBIND (IDARUCIZUMAB)?

    <p>Thromboembolism</p> Signup and view all the answers

    What is the primary target of Vorapaxar (Zontivity)?

    <p>PAR-1</p> Signup and view all the answers

    Which enzyme is estimated to be low in 2-14% of the US population and is needed to activate clopidogrel?

    <p>CYP2C19</p> Signup and view all the answers

    What is a potential side effect of Vorapaxar (Zontivity) administration?

    <p>Hypokalemia</p> Signup and view all the answers

    What is the circulating half-life of Vorapaxar (Zontivity)?

    <p>~3 days</p> Signup and view all the answers

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