Podcast
Questions and Answers
What is the primary goal of computer-aided ligand design methods?
What is the primary goal of computer-aided ligand design methods?
- To construct a ligand atom by atom
- To determine desirable locations of atoms within the active site (correct)
- To assess the shape of the compounds placed in the active site
- To place compounds into the active site randomly
Which method constructs a ligand atom by atom?
Which method constructs a ligand atom by atom?
- Sequential buildup method (correct)
- Site point connection method
- Whole molecule method
- Fragment connection method
In which method are fragments positioned and connected using linkers or scaffolds?
In which method are fragments positioned and connected using linkers or scaffolds?
- Random connection method
- Whole molecule method
- Fragment location method
- Site point connection method (correct)
Which class of techniques combines features of fragment connection and sequential buildup methods, along with bond disconnection strategies?
Which class of techniques combines features of fragment connection and sequential buildup methods, along with bond disconnection strategies?
What is the purpose of whole molecule methods in ligand design?
What is the purpose of whole molecule methods in ligand design?
Which method involves determining locations as 'site points' and then placing fragments within the active site to occupy those locations?
Which method involves determining locations as 'site points' and then placing fragments within the active site to occupy those locations?
What is the primary purpose of Quantitative Structure Activity Relationships (QSAR)?
What is the primary purpose of Quantitative Structure Activity Relationships (QSAR)?
What is the main alternative to get a 3D representation of the target in the absence of crystal structures?
What is the main alternative to get a 3D representation of the target in the absence of crystal structures?
What is the term used for quantitative structure toxicity relationship modeling applied to toxicological data?
What is the term used for quantitative structure toxicity relationship modeling applied to toxicological data?
Which approach is considered a complementary method to experimental high throughput screening (HTS) in lead identification?
Which approach is considered a complementary method to experimental high throughput screening (HTS) in lead identification?
What is the Latin expression for 'from the beginning' in the context of drug design?
What is the Latin expression for 'from the beginning' in the context of drug design?
How does QSAR contribute to the lead optimization process in drug design?
How does QSAR contribute to the lead optimization process in drug design?
What is pharmacophore modeling primarily used for in ligand based drug design?
What is pharmacophore modeling primarily used for in ligand based drug design?
What information can be used to design ligands specific to a target in De novo Drug Designing?
What information can be used to design ligands specific to a target in De novo Drug Designing?
Which type of relationships does quantitative structure–activity relationship (QSAR) model represent?
Which type of relationships does quantitative structure–activity relationship (QSAR) model represent?
Which method involves explicit molecular docking of ligands to the binding site of the target for scoring?
Which method involves explicit molecular docking of ligands to the binding site of the target for scoring?
What is the main goal of the lead optimization process in drug design?
What is the main goal of the lead optimization process in drug design?
What makes experimental testing easy and false positives tolerable in Structure Based Virtual Screening?
What makes experimental testing easy and false positives tolerable in Structure Based Virtual Screening?
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