Podcast
Questions and Answers
What role do C3a and C5a play in inflammation?
What role do C3a and C5a play in inflammation?
- Suppress the opsonization of pathogens
- Inhibit the release of proinflammatory cytokines
- Recruit phagocytes and promote inflammation (correct)
- Prevent anaphylactic shock
How do complement receptors connect complement-tagged pathogens to effector cells?
How do complement receptors connect complement-tagged pathogens to effector cells?
- Through inhibition of proinflammatory cytokine release
- By stimulating the release of granule components from phagocytes
- By facilitating the binding of complement-tagged pathogens to effector cells (correct)
- By promoting pathogen lysis
How does opsonization enhance phagocytosis?
How does opsonization enhance phagocytosis?
- Prevents pathogen lysis
- Makes pathogens more readily taken up by phagocytosis (correct)
- Reduces the uptake of pathogens by phagocytes
- Promotes inflammation
What is the function of properdin (factor P) in the alternative pathway of complement activation?
What is the function of properdin (factor P) in the alternative pathway of complement activation?
Which complement factor creates the membrane-attack complex (MAC) that leads to pathogen lysis?
Which complement factor creates the membrane-attack complex (MAC) that leads to pathogen lysis?
What is the main downstream effect of large amounts of C3a and C5a?
What is the main downstream effect of large amounts of C3a and C5a?
What is the key mechanism of action of the complement system related to inflammation?
What is the key mechanism of action of the complement system related to inflammation?
Which process involves the coating of a pathogen's surface to make it more easily ingested by phagocytes?
Which process involves the coating of a pathogen's surface to make it more easily ingested by phagocytes?
What is the main function of phagocytosis in cellular processes?
What is the main function of phagocytosis in cellular processes?
How is the complement system initially activated?
How is the complement system initially activated?
Which proteins circulate in the blood until activated and initiate their respective complement reactions?
Which proteins circulate in the blood until activated and initiate their respective complement reactions?
Which fragment of the complement system identified by 'a' after its name has a specific function?
Which fragment of the complement system identified by 'a' after its name has a specific function?
What is the main function of C3 convertase in the complement system?
What is the main function of C3 convertase in the complement system?
What is the role of negative regulation in complement activation?
What is the role of negative regulation in complement activation?
Which pathway is triggered by soluble proteins known as lectins?
Which pathway is triggered by soluble proteins known as lectins?
What is the role of pro-proteases in the complement system?
What is the role of pro-proteases in the complement system?
What is one of the main outcomes of inhibiting the formation of MAC on host cells?
What is one of the main outcomes of inhibiting the formation of MAC on host cells?
Which protein prevents the appearance of C3 convertase under normal/basal conditions?
Which protein prevents the appearance of C3 convertase under normal/basal conditions?
Which molecule is involved in enhancing inflammation according to the text?
Which molecule is involved in enhancing inflammation according to the text?
What is the main function of C3b as discussed in the text?
What is the main function of C3b as discussed in the text?
Which protein is involved in the negative regulation of MAC formation by inhibiting the assembly of the Membrane Attack Complex?
Which protein is involved in the negative regulation of MAC formation by inhibiting the assembly of the Membrane Attack Complex?
Which pathway results in the generation of C3 convertase (C4b2a) according to the text?
Which pathway results in the generation of C3 convertase (C4b2a) according to the text?
What is the function of C3b in the complement system?
What is the function of C3b in the complement system?
What initiates an amplification loop for C3b formation in the alternative pathway?
What initiates an amplification loop for C3b formation in the alternative pathway?
Which outcome is NOT associated with complement activation?
Which outcome is NOT associated with complement activation?
Which molecule is involved in phagocytosis enhancement in the complement system?
Which molecule is involved in phagocytosis enhancement in the complement system?
What happens under normal/basal conditions due to the presence of complement-regulatory proteins?
What happens under normal/basal conditions due to the presence of complement-regulatory proteins?
What is the role of C1q in the complement system based on the text?
What is the role of C1q in the complement system based on the text?
